Results 101 to 110 of about 1,996,956 (313)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

What Policies and Practices Can HR Utilize to Promote an Innovation Based Culture and Help Drive Business Outcomes Through It? [PDF]

, 2017
[Excerpt] Innovation has evolved from a mainly scientific activity of research and development to a complex system of interactions among various participants both inside and outside of a firm.
Lai, Han, Lundgren, Andrew
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

ANALYSIS OF INNOVATION ACTIVITY OF SLOVAK AND CZECH ENTERPRISES [PDF]

Kvalita Inovácia Prosperita, 2010
European innovation scoreboard is used to monitor and compare the innovation performance of European countries, according to which was the Slovak Republic, together with two other V4 countries, i.e.
EMÍLIA SPIŠÁKOVÁ
doaj  

Mastery in Goal Scoring, T-Pattern Detection, and Polar Coordinate Analysis of Motor Skills Used by Lionel Messi and Cristiano Ronaldo

Frontiers in Psychology, 2017
Research in soccer has traditionally given more weight to players' technical and tactical skills, but few studies have analyzed the motor skills that underpin specific motor actions. The objective of this study was to investigate the style of play of the
Marta Castañer, Daniel Barreira, Oleguer Camerino, M. Teresa Anguera, Tiago Fernandes, Raúl Hileno   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

O valor educativo do desporto: Desafios e dificuldades percebidas por treinadores de crianças e jovens

Motricidade
Este estudo investigou os desafios e dificuldades enfrentadas pelos treinadores ao transmitir valores educativos do desporto e as suas estratégias para lidar com a falta desses valores nos seus jovens atletas.
Rafael Ramos, Ivo Cortinhas, Luís Aguilar, Teresa Fonseca, Helder Miguel Fernandes   +4 more
doaj   +1 more source

A legacy handbook for innovation [PDF]

, 2011
Legacy Handbook reviewing emda's experience of innovation activity. Identifies key achievements and draws out lessons learned that may be relevant to successor bodies active in this ...
East Midlands Development Agency, EMDA
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Implications of pubertal stage in cardiometabolic risk factors in obese adolescents: a network analysis

BMC Pediatrics
Introduction Despite the existence of numerous studies describing the early stages of sexual maturation in overweight children, there is still a gap in understanding the consequences of obesity at each level of pubertal development and its association ...
Déborah Cristina de Souza Marques, Mileny Caroline Menezes de Freitas, Marilene Ghiraldi de Souza Marques, Luciana Lozza de Moraes Marchiori, Thiago Kenzo Guinoza Lima, Joed Jacinto Ryal, Clarice Maria de Lucena Martins, Jorge Mota, Pablo Valdés-Badilla, Braulio Henrique Magnani Branco   +9 more
doaj   +1 more source