Results 101 to 110 of about 1,971,957 (315)
Regional food clusters and government support for clustering: Evidence for a ‘dynamic food innovation cluster’ in Alberta, Canada? [PDF]
Location-based clusters and virtual cluster configurations have received significant attention from policymakers due to their potential implications on productivity, innovation and regional growth.
Ali, Jolene, Steiner, Bodo
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A legacy handbook for innovation [PDF]
, 2011 Legacy Handbook reviewing emda's experience of innovation activity. Identifies key achievements and draws out lessons learned that may be relevant to successor bodies active in this ...
East Midlands Development Agency, EMDA
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ANALYSIS OF INNOVATION ACTIVITY OF SLOVAK AND CZECH ENTERPRISES [PDF]
Kvalita Inovácia Prosperita, 2010 European innovation scoreboard is used to monitor and compare the innovation performance of European countries, according to which was the Slovak Republic, together with two other V4 countries, i.e.
EMÍLIA SPIŠÁKOVÁ
doaj
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
MotricidadeEste estudo investigou os desafios e dificuldades enfrentadas pelos treinadores ao transmitir valores educativos do desporto e as suas estratégias para lidar com a falta desses valores nos seus jovens atletas.
Rafael Ramos +4 more
doaj +1 more source
Does a foreign subsidiary's network status affect its innovation activity? Evidence from post-socialist economies [PDF]
A detailed questionnaire survey among 809 foreign subsidiaries in five post-socialist economies (East Germany, Poland, Romania, Slovenia and Croatia) is used to study determinants of innovation activity of foreign subsidiaries.
Jože P. Damijan +2 more
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
BMC PediatricsIntroduction Despite the existence of numerous studies describing the early stages of sexual maturation in overweight children, there is still a gap in understanding the consequences of obesity at each level of pubertal development and its association ...
Déborah Cristina de Souza Marques +9 more
doaj +1 more source
PERMANENT INNOVATION - SOLUTION FOR THE INCREASE OF THE COMPETITIVENESS OF THE COMPANIES [PDF]
The economy based on knowledge imposes a careful administration of the innovation activity at the level of the companies parallel to the possibility of the formation of innovation networks - competitive poles - clusters.
Corina FRÃSINEANU, Ioan FRÃSINEANU
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