Results 91 to 100 of about 923,769 (294)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Записки Горного института, 2017 This paper examines problems related to forming a complex of indicators to assess innovation potential of an industrial enterprise, on the example of coal industry enterprises, and an integral indicator of innovation potential, used for comparative ...
A. V. Kozlov, A. B. Teslya, Sya Chzhan
doaj +1 more source
The Lisbon Strategy Targets are presented and assessed as accordingly to the domains of the structural indicators, the common indicators created to measure the progress towards reaching these objectives: Economic performance; Employment; Research ...
Ivan Ungureanu, Clementina +1 more
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
EVOLUTIONANALYSIS OF ECO-INNOVATION INROMANIA IN THE CONTEXT OF SUSTAINABILITY [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015 In the current context, sustainability is a necessity of global development crisis. Its manifestations comprised in time the eco-innovation. In the last decade eco-innovation, it has faced significant developments, both internationally and nationally.
GOGONEA RODICA-MANUELA
doaj
Organizational Competencies and Innovation Performances: The Case of Large Firms in Belgium [PDF]
The objective of this paper is to assess whether large firms' organizational competencies affect their innovation performances. About 40 organizational sub-competencies are defined and measured through an original survey questionnaire answered by 148 ...
Peeters, Carine +1 more
core
The multiple facets of regional innovation [PDF]
, 2014 Measuring innovation activities involves critical decisions in selecting appropriate indicators and levels of observation. The present article contributes to the literature on this subject by addressing innovation measurement on the regional level.
Hauser, Christoph +3 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Innovation and business performance - a provisional multi-regional analysis [PDF]
Although much attention has focussed on the determinants of firms' innovation performance, the relationship between innovation and business performance is less well defined.
Hewitt-Dundas, Nola +4 more
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source