Results 81 to 90 of about 181,588 (262)
An empirical research on management innovation of high-technology manufacturers
Advances in Mechanical Engineering, 2015 Management innovation is the method with which enterprises acquire competitive advantage over their competitors, especially in current fierce competitive industry environment.
Po-Yu Huang +11 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
EVOLUTIONANALYSIS OF ECO-INNOVATION INROMANIA IN THE CONTEXT OF SUSTAINABILITY [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015 In the current context, sustainability is a necessity of global development crisis. Its manifestations comprised in time the eco-innovation. In the last decade eco-innovation, it has faced significant developments, both internationally and nationally.
GOGONEA RODICA-MANUELA
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Indicators of innovation in a knowledgebased economy
Cybermetrics, 2001 Peer ...
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Open Access Journal of ContraceptionSyahmida Syahbuddin Arsyad,1 Laili Rahayuwati,2 Rahmadewi,1 Septi Nurhayati,1 Arga Nugraha,3 Darojad Nurjono Agung Nugroho,4 Oktriyanto,1 Mugia Bayu Rahardja,1 Yanu Endar Prasetyo,1 Yanti Astrelina Purba,1 Ruth Meilianna,1 Indra Murty Surbakti,5 Wahyu ...
Syahbuddin Arsyad S +13 more
doaj
Elderly Golden Age School (EGAS): a strategy to promote health and prosperity elderly in Indonesia
Humanities & Social Sciences CommunicationsMost elderly citizens face health problems and difficulties although they are economically productive and independent. This study developed a prototype for promoting health and prosperity within the Elderly Golden Age School (EGAS) for ageing populations.
Iswari Hariastuti +8 more
doaj +1 more source