Results 121 to 130 of about 23,707,889 (338)

Stability evaluation of high-order splitting method for incompressible flow based on discontinuous velocity and continuous pressure

Advances in Mechanical Engineering, 2019
In this work, we deal with high-order solver for incompressible flow based on velocity correction scheme with discontinuous Galerkin discretized velocity and standard continuous approximated pressure.
Liyang Xu, Xinhai Xu, Xiaoguang Ren, Yunrui Guo, Yongquan Feng, Xuejun Yang   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Instrumental and experiential attitudes toward (A.I.) augmented decision-making at work

Computers in Human Behavior: Artificial Humans
In augmented decision-making, defined as a process wherein human judgment is complemented with decision-support systems powered by artificial intelligence (A.I.-DSS), employees are expected to monitor and sometimes override system outputs to enhance ...
Kees Maton, Pascale Le Blanc, Philippe van de Calseyde, Anna-Sophie Ulfert   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

‘I Do Often Feel Like We Were Given a Magic Wand’ – Children's and Families’ Experiences of Allied Health Services for Developmental and Disability Needs in Rural and/or Remote South Australia

Health Expectations
Background Children in rural and remote areas are increasingly developmentally vulnerable compared to metropolitan peers. Allied health professionals are positioned to provide services to support children with developmental and disability needs but face ...
Georgia Gosse, Saravana Kumar, Helen Banwell, Joshua Pate   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Mergers & Acquisitions and Innovation Performance in the Telecommunications Equipment Industry [PDF]

In response to global market forces such as deregulation and globalization, technological change and digital convergence, the telecommunications in the 1990s witnessed an enormous worldwide round of Mergers & Acquisitions (M&A).
Tseveen Gantumur, Andreas Stephan
core   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Small firm innovation performance and employee involvement. [PDF]

It is known that small firms rely mainly on the CEO’s individual knowledge for developing innovations. Recent work suggests that this approach is inefficient since it underutilizes other employees’ knowledge. We study to which extent using CEOs, managers
Czarnitzki, Dirk, Andries, Petra
core