Results 121 to 130 of about 11,105,485 (312)

Assessing the Origins, Evolution and Prospects of National Innovation Systems. [PDF]

J Knowl Econ, 2022
López-Rubio P, Roig-Tierno N, Mas-Verdú F.   +2 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Assessing climate change mitigation and adaptation strategies and agricultural innovation systems in the Niger Delta. [PDF]

GeoJournal, 2023
Ikehi ME, Ifeanyieze FO, Onu FM, Ejiofor TE, Nwankwo CU.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Education, Innovation, and Knowledge Economy in Advancing Sustainable Development Goals: A Multidisciplinary Study

Jurnal Multidisiplin Ibrahimy
The study investigates how key elements of the knowledge economy, human capital, innovation systems, ICT infrastructure, and institutional frameworks shape the performance of selected Sustainable Development Goals (SDGs).
Nathan Udoinyang, Amos Salamat Umoh
doaj   +1 more source

National Innovation Systems in Low-Income and Middle-Income Countries: Re-evaluation of Indicators and Lessons for a Learning Economy in Senegal. [PDF]

J Knowl Econ, 2022
Casadella V, Tahi S.
europepmc   +1 more source

A Systemic Approach to Innovation

, 2002
The context of this chapter is set by the contemporary transition from an industrial to a knowledge-based economy. OECD (1996a) has documented the way in which the knowledge-based economy of learning individuals, organisations and economies is emerging out of the machine-based economy that determined advanced economies in most of the time in the 20th ...
openaire   +3 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Educational Innovation and University Research, Distinction, Points of Contact and Productive Interactions

Education Sciences
Higher education is undergoing a constant paradigm shift, transforming itself into a system of innovation for society. This study has explored and determined the relationship between educational innovation and research in university contexts in order to ...
Raquel Ayala-Carabajo, Joe Llerena-Izquierdo   +1 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source