Results 131 to 140 of about 11,105,485 (312)

Channeling diverse innovation pressures to support European sustainability transitions

Environmental Research Letters, 2021
Elena Verdolini, Benjamin K Sovacool, Paul Drummond   +2 more
doaj   +1 more source

Bridging roles in responsible innovation systems: from transfer to relational knowledge

Journal of Responsible Innovation
Bridging roles play a pivotal part in shaping responsible innovation (RI) systems, where the quality of relationships among diverse actors fundamentally influences systemic outcomes.
Paula Otero-Hermida
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

From processing-centered innovation to analytical diversification: network evolution in virgin olive oil patents

Frontiers in Research Metrics and Analytics
IntroductionThis study examines how the technological structure of virgin olive oil (VOO) innovation evolved between 1990 and 2025. It asks whether the sector moved beyond its traditional processing base toward a more diversified innovation system, and ...
Turhan Karakaya, Sezai Tunca, Yavuz Selim Balcioglu   +2 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Systemic capacities and capabilities for mission-oriented innovation policies: the case of Brazil’s Inova programme

Policy Design and Practice
This paper refines, operationalizes, and empirically applies a systemic framework for analyzing the capacities and capabilities required for successful mission-oriented innovation policies.
Caetano C. R. Penna, Mariana Mazzucato, Guilherme de Oliveira Santos   +2 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Synergy in the Iranian Innovation Systems at Regional and National Levels In the Triple-Helix Context

International Journal of Information Science and Management, 2018
The synergies for the Iranian regional and national innovation systems among the geographical, technological and organizational distributions of firms were measured.
Hoda Abedi, Fahimeh Babalhavaeji, Mohammad Hassanzadeh   +2 more
doaj  

Unlocking agroforestry transitions

International Journal of Agricultural Sustainability
Despite decades of evidence demonstrating the environmental and socio-economic benefits of agroforestry, transitions toward tree-based farming systems remain limited across most agricultural landscapes.
Alain Rival, Philippe Guizol, Denis Fabre   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source