Results 21 to 30 of about 356 (146)

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, Volume 293, Issue 8, Page 2314-2340, April 2026.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Qualitative Insights on Preventive Group Training in LTC Facilities: Key Influencing Factors

International Journal of Language &Communication Disorders, Volume 61, Issue 2, March/April 2026.
ABSTRACT Background The cluster randomised controlled trial OrkA (Orofaciopharyngeal and linguistic‐communicative activation in older age) aims to evaluate the efficacy of a preventive group programme for older adults in long‐term care (LTC) facilities. The programme objective is to support the maintenance of swallowing, speech and communication skills
Isabell Fesser, Klaus Hager, Simone Miller, Wenke Walther   +3 more
wiley   +1 more source

Nanoteknologi og materialekemi - nye muligheder for fremtidens energiteknologier [PDF]

, 2004
Nanoteknologi har fået en fremtrædende rolle i offentlighedens opfattelse af fremtidens naturvidenskab. Det er også et område, der har stor politisk bevågenhed.
Linderoth, Søren, Smith, A.
core  

Evaluation eines Konzeptes zur Verbesserung der Patienteninformation und -kommunikation und der Kompetenzförderung in der Onkologie [PDF]

Die psychologische/psychosoziale Unterstützung von Krebspatient*innen ist neben der Behandlung ein wichtiger Faktor für deren Gesundheit. Außer den etablierten stationären sowie ambulanten Leistungserbringern gibt es zahlreiche Versuche, durch ...
Schneider, Nico
core   +1 more source

Effects of Exercise Duration and Intensity on Maximal Exercise Capacity Over 6 Months in Coronary Heart Disease and Type 2 Diabetes—A Secondary Analysis of the LeIKDTrial

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 1, January 2026.
ABSTRACT Exercise training is recommended in coronary heart disease (CHD) and type 2 diabetes (T2DM) patients alike; however, uncertainty remains on the influence of exercise intensity and duration in older patients with both entities. To address this, we performed a secondary analysis including 201 patients (67.9 ± 8.2 years; 84.1% men) from the LeIKD
Felix Gass, Sophia M. Dinges, Isabel Fegers‐Wustrow, Felix Freigang, Patrizia Maier, Matthias Arnold, Ephraim B. Winzer, Frank Edelmann, Oliver Wolfram, Julia Brandts, Bernd Wolfarth, Marcus Dörr, Rolf Wachter, Björn Hackenberg, Sarah Rust, Thomas Nebling, Volker Amelung, Martin Halle, Stephan Mueller   +18 more
wiley   +1 more source

Hybrid Nanoparticles Separated by Buoyant Density in a Large‐Scale Centrifugal Process

Journal of Polymer Science, Volume 63, Issue 21, Page 4488-4502, 1 November 2025.
Zonal rotors, shaped like hollow bowls, can sort mixtures of macromolecules and polymer nanoparticles based only on their densities, regardless of their actual sizes or shapes. Using these rotors can make a big difference because they do not need to use centrifuge tubes.
Claudia Simone Plüisch, Rouven Stuckert, Alexander Wittemann   +2 more
wiley   +1 more source

Resolving the effects of functional traits on tree growth rates: The influence of temporal dynamics and divergent strategies by leaf habit

Journal of Ecology, Volume 113, Issue 11, Page 3191-3209, November 2025.
Functional traits are not consistently associated with tree growth rates but instead reflect dynamic resource acquisition and investment strategies over time and between deciduous and evergreen species. Despite this variability, our findings confirm the utility of functional traits to predict tree growth rates, especially when trait effects are ...
Mégane Déziel, Daniel Schoenig, Rita Sousa‐Silva, Eric B. Searle, William C. Parker, Jeannine Cavender‐Bares, Simone Mereu, Michael Scherer‐Lorenzen, Charles A. Nock, Christian Messier, Peter Reich, Artur Stefanski, Ning Dong, Peter Hajek, Dominique Gravel, Alain Paquette   +15 more
wiley   +1 more source

Projekttransfer auf Basis systematischer Übersichtsarbeiten – Konzept zur Weiterentwicklung des Innovationsfonds

Monitor Versorgungsforschung, 2022
Die Empfehlungen des Innovationsausschusses beim G-BA zur Überführung von Innovationsfondsprojekten in die Regelversorgung offenbaren zunehmend ein grundlegendes Problem des bestehenden Transferregimes: Schwierigkeiten bei der Evaluation und die teilweise sehr spezifische Projektgestaltung schränken die Generalisierbarkeit von Projektergebnissen ein ...
Dr. rer. med. Florian Brandt MSc, Jonas Grininger, Christopher Venus, Dr. med. Dr. med. dent. Christoph Homann MBA, Tim Hollmann   +4 more
openaire   +2 more sources

Cost‐Effectiveness of Family Conferences to Reduce Polypharmacy in Frail Older Adults

Journal of the American Geriatrics Society, Volume 73, Issue 10, Page 3009-3020, October 2025.
ABSTRACT Background Cost‐effectiveness of family conferences on deprescribing with joint prioritization of treatment goals in primary care has not been investigated so far. We assessed cost‐effectiveness in the cluster‐randomized controlled COFRAIL trial conducted with general practitioners and 521 older frail patients with polypharmacy cared for at ...
Joseph Montalbo, Charalabos‐Markos Dintsios, Jens Abraham, Eva Drewelow, Manuela Ritzke, Achim Mortsiefer, Birgitt Wiese, Petra Thürmann, Stefan Wilm, Andrea Icks, COFRAIL study group   +10 more
wiley   +1 more source

Two‐year outcomes of epicranial focal cortex stimulation in pharmacoresistant focal epilepsy

Epilepsia, Volume 66, Issue 9, Page 3242-3253, September 2025.
Abstract Objective This study was undertaken to report on the long‐term safety and efficacy of epicranial focal cortex stimulation (FCS) using the EASEE device as adjunctive neuromodulatory therapy in improving seizure control in adults with pharmacoresistant epilepsy originating from one predominant epileptogenic zone.
Andreas Schulze‐Bonhage, Martin Hirsch, Susanne Knake, Ann Mertens, Michael Rademacher, Elisabeth Kaufmann, Josua Kegele, Carolin Jenkner, Volker Coenen, Martin Glaser, Sergiu Groppa, Yaroslav Winter, for the EASEE Study Group   +12 more
wiley   +1 more source