Results 121 to 130 of about 2,765,900 (304)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Flipped classroom and a new hybrid "Teach the Airway Teacher" course: an innovative development in airway teaching? [PDF]

Trends Anaesth Crit Care, 2022
Cortese G, Greif R, Mora PC.
europepmc   +1 more source

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Molecular Medicine
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability.
Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu   +12 more
doaj   +1 more source

Innovation, Trade and Finance [PDF]

The paper proposes a model where heterogeneous firms choose whether to undertake R&D or not. Depending on R&D choice, innovative firms are more productive, have larger investment opportunities and lower own funds than non-innovating firms.
Christian Keuschnigg, Peter Egger
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Innovative Development of Batch Dyed 3D Printed Acrylonitrile/Butadiene/Styrene Objects. [PDF]

Molecules, 2021
Kutnjak-Mravlinčić S, Sutlović A, Glogar MI, Ercegović Ražić S, Godec D.   +4 more
europepmc   +1 more source

An Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC–MS/MS) Method for Qualifying DAPB in Rat Plasma and Application to Pharmacokinetic Studies

Molecules
DAPB, a new molecule including danshensu, borneol, and a mother nucleus of ACEI (Angiotensin-converting enzyme inhibitors), is being developed as an antihypertensive candidate compound.
Bei Qin, Yunmei Chen, Kuan Yang, Rong Wang, Lili Yu, Nana Wang, Shaojing Liu   +6 more
doaj   +1 more source

Innovative Rural Development Initiatives [PDF]

, 2002
This Interim Report provides first results from case studies of innovative rural development initiatives in Europe. They were conducted by IIASA's European Rural Development (ERD) project during 2001 -- primarily to test the feasibility of the research ...
Heilig, G.K., Pontieri, A., Wickenhagen, A.   +2 more
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Innovative Development of Pasta with the Addition of Fish By-Products from Two Species. [PDF]

Foods, 2021
Ainsa A, Honrado A, Marquina PL, Roncalés P, Beltrán JA, Calanche M JB.   +5 more
europepmc   +1 more source