Results 101 to 110 of about 2,765,900 (304)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Financing the Investment Projects in Regions in globalization [PDF]

, 2013
The urgent problems of financing the investment strategy in the regions of Ukraine are examined in globalization. The directions of further development of the investment resources mobilization system and their management are determined in order to apply ...
Liudmyla Solianyk
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Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Investigation of the impact of diverse climate conditions on the cultivation suitability of Cinnamomum cassia using the MaxEnt model, HPLC and chemometric methods in China

Scientific Reports
Cinnamomum cassia Presl. is a subtropical plant that is used for food and medicine. Climate change has changed the suitable habitats of medicinal plants, which might have repercussions for the efficacy of herbal remedies.
Yanqun Li, Yang Yang, Dingze Gu, Yanrong Cheng, Xuejuan Lv, Yan Huang, Peng Ye, Xinxuan Zhang, Jing Zhang, Wanying Jian, Yujie Liu, Yingtong Guo, Mei Bai, Rongshao Huang, Hong Wu   +14 more
doaj   +1 more source

SHR-1806, a robust OX40 agonist to promote T cell-mediated antitumor immunity

Cancer Biology & Therapy
Anti-CTLA-4 and anti-PD-1/PD-L1 antibodies have significantly revolutionized cancer immunotherapy. However, the persistent challenge of low patient response rates necessitates novel approaches to overcome immune tolerance.
Jun Zhang, Lei Zhou, Xing Sun, Yuan Lin, Jimin Yuan, Changyong Yang, Cheng Liao   +6 more
doaj   +1 more source

Immune Checkpoint Blockade in Cancer Treatment: A Double-Edged Sword Cross-Targeting the Host as an “Innocent Bystander”

Toxins, 2014
Targeted immune checkpoint blockade augments anti-tumor immunity and induces durable responses in patients with melanoma and other solid tumors. It also induces specific “immune-related adverse events” (irAEs).
Lucia Gelao, Carmen Criscitiello, Angela Esposito, Aron Goldhirsch, Giuseppe Curigliano   +4 more
doaj   +1 more source

Management of innovative activity under economic and financial changes [PDF]

In modern conditions, one of the main tasks of innovative activity’s efficiency is to develop a new concept of innovative processes' management.
Nazarova, Rano
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Bringing research results to users: the case for a knowledge resource centre [PDF]

, 2015
Poster presented at Scientific and Technical Information and Rural Development: Highlights of Innovative Practices. 13. IAALD World Congress.
Blomme, Guy, Er Rachiq, L., Johnson, V., Karamura, E.B., Picq, C., Schagen, Boudy van   +5 more
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