Results 81 to 90 of about 2,765,900 (304)

Recent advances in triple negative breast cancer: the immunotherapy era

BMC Medicine, 2019
Background Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over the last year. The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer ...
Antonio Marra, Giulia Viale, Giuseppe Curigliano   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The transcriptome analysis reveals the regulatory mechanisms of female sterility in Lagerstroemia speciosa ‘Zichan’

BMC Plant Biology
Background Ovule abortion presents a major biological obstacle to hybrid breeding in the genus Lagerstroemia, but its molecular regulatory mechanisms remain inadequately understood.
Ruoyong Yin, Shuaijie Lu, Baojin Zhang, Fei Xiao, Lan Wang, Ruchun Xi, Xiaomei Deng   +6 more
doaj   +1 more source

Innovative Green Technology for Sustainable Industrial Estate Development

, 2013
Sustainable industrial development requires a balance between economic growth, equity and environment. Two major components of industrial development are energy and raw materials.
P., Purwanto, R., Hadiwijoyo, Sudharto, P Hadi   +2 more
core  

Development of Innovative Heat Sinks for Power Electronics Cooling within the More Electrical Aircraft [PDF]

, 2019
Peer ReviewedPostprint (published ...
Hoell, Klaus, McKay, Connor, Migneau, Maxime, Mullen, David, Naseri, Alireza, Oliet Casasayas, Carles, Oliva Llena, Asensio, Preishuber-Pfluegl, Florian, Rigola Serrano, Joaquim   +8 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

STATE AND DIRECTIONS OF INNOVATIVE DEVELOPMENT OF INDUSTRY IN RUSSIA

Russian Journal of Economics and Law, 2012
The article analyzes the dynamics of the main indicators of the innovative development of the Russian industry in interconnection with the main provisions of strategy of innovative development of Russia till 2020.
E. A. Tretyakova
doaj  

Comparative transcriptomic analysis of petaloid stamen formation in Lagerstroemia speciosa ‘Zijuan’

BMC Genomics
Background Lagerstroemia speciosa ‘Zijuan’ is a new variety of L. speciosa with highly petaloid stamens that exhibit ornamental value but sterility. To investigate the mechanism of stamen petaloidy, this study compared the morphological structures and ...
Baojin Zhang, Ruoyong Yin, Shuaijie Lu, Lan Wang, Fei Xiao, Ruchun Xi, Xiaomei Deng   +6 more
doaj   +1 more source

Assessing essential oil composition in Cinnamomum cassia leaves from different regions of China using GC-MS and FTIR spectroscopy

Czech Journal of Food Sciences
In this study, volatile compounds from Cinnamomum cassia Presl. leaves from different regions of China were identified using gas chromatography coupled with mass spectrometry (GC-MS) and Fourier-transform infrared (FTIR) spectroscopy combined with ...
Yan Huang, Yujie Liu, Huiping Tan, Yanrong Cheng, Kunyang Tao, Dingze Gu, Huaizu Cai, Chengjie Li, Kaiyi Guo, Cheng Wu, Hong Wu, Yanqun Li   +11 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source