Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Study on the Excretion of a New Antihypertensive Drug 221s (2,9) in Rats
PharmaceuticalsBackground/Objectives: The novel compound 221s (2,9), derived from danshensu and ACEI-active proline, exhibits antihypertensive effects (50/35 mmHg SBP/DBP reduction in SHRs) with potential cough mitigation.
Yunmei Chen +5 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
ToxinsCompound 221s (2,9) is a novel antihypertensive drug candidate synthesized utilizing danshensu, borneol, and proline by using the strategy of combinatorial molecular chemistry.
Yunmei Chen +5 more
doaj +1 more source
Development Assistance and Development Finance: Evidence and Global Policy Agendas [PDF]
official development assistance, growth, poverty, Millennium Development Goals, sub-Saharan Africa, Pacific, innovative ...
Addison, Tony +2 more
core
Reframing the Work of Rural Community Development: Case Studies in Innovative Rural Business Strategies [PDF]
, 2007 Much of community development work in this country is understood in urban terms - densely populated areas with attendant economies of scale, housing issues that can be addressed largely in isolation of economic development and infrastructure issues ...
Anne Gass, David Dangler, Marcia Nedland
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Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Вектор соціального розвитку України в контексті перспектив побудови інноваційної економіки
, 2014 The article is devoted to the problems of social and human development in the context of transformation of modern economy into innovative one. Theoretical analysis of the main directions of human development have been carried out.
Semykina, Anna +1 more
core
Innovative Stormwater Treatment Technologies: Best Management Practices Manual [PDF]
, 2002 Urban stormwater carries a number of pathogens, nutrients, heavy metals, sediment, and other contaminants as surface runoff flows over land. The increase in impervious or paved surfaces associated with development in urban areas reduces the natural ...
Bisbee, G. Dana +2 more
core +1 more source
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source