Results 31 to 40 of about 770,778 (290)

Data-driven through-life costing to support product lifecycle management solutions in innovative product development [PDF]

open access: yes, 2011
Innovative product usually refers to product that comprises of creativity and new ideas. In the development of such a new product, there is often a lack of historical knowledge and data available to be used to perform cost estimation accurately.
Cheung, Wai Ming   +4 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Ground deformation monitoring of landslides and precipitation-triggered mechanisms using GBInSAR

open access: yesFrontiers in Earth Science
Landslides are common in mountainous, hilly, and steep-slope regions, posing serious threats to human life, infrastructure, and ecological systems. Precipitation is a major triggering factor that can rapidly destabilize slopes by increasing moisture ...
Di Yao, Di Yao, Yingchao Dai, Ziwei Zhao
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Synthetic CT generation for pelvic cases based on deep learning in multi-center datasets

open access: yesRadiation Oncology
Background and purpose To investigate the feasibility of synthesizing computed tomography (CT) images from magnetic resonance (MR) images in multi-center datasets using generative adversarial networks (GANs) for rectal cancer MR-only radiotherapy ...
Xianan Li   +10 more
doaj   +1 more source

Chemical Fingerprint and Metabolic Profile Analysis of Tianshu Tablets by Ultra-High Performance Liquid Chromatography/Quadrupole-Time of Flight Mass Spectrometry

open access: yesJournal of Analytical Methods in Chemistry, 2019
In recent years, the chemical fingerprinting of traditional Chinese medicines and the metabolites in these compounds has been a hot topic. In the present study, the chemical fingerprint of Tianshu tablets (TST) and the metabolic characteristics of ...
Lin Chen   +6 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

New understanding on the pearlite-induced brittle failure of bimetal composite interface

open access: yesMaterials & Design
The pearlite–austenite interface is the primary cause of brittle failure of the Mn8/SS400 bimetal composite. Here, we present new microstructural understandings on this interfacial brittle failure.
Lisong Zhu   +9 more
doaj   +1 more source

Silicon carbide equipments for process intensification of silicon reactions. [PDF]

open access: yes, 2009
Bluestar Silicones, one of the worldwide leaders in silicones chemistry, proposes a R&D project, aiming to design new equipment for the transposition of batch to continuous processes. The safety and environmental issues linked to this type of chemicals,
Elgue, Sébastien   +5 more
core  

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