Results 101 to 110 of about 820,234 (313)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Assessing the Impact of Public Support on Innovative Productivity [PDF]

Previous policy evaluation literature mainly aimed at estimating the additional effect of public support on either firms’ innovative inputs or innovative outputs.
Alessandra Catozzella, Marco Vivarelli
core  

The Need for Innovation of Security Education for Strengthening the Results of Traditional Teaching at Universities

Communications, 2016
This article deals with security education and the possibilities of innovative methods application in this kind of education at universities. The continuous development of science and technology, as well as constantly changing social needs which are ...
Martina Vackova, Lucia Kovacova, Maria Kancirova, Peter Losonczi   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

INNOVATIONS AND INNOVATIVE METHODS IN ORGANIZATIONAL MANAGEMENT

Innovations and innovative methods in organizational management involve introducing new ideas, tools, processes, and strategies to improve efficiency, effectiveness, and adaptability. These innovations help organizations stay competitive in a rapidly changing environment, enhance decision-making, and better meet the needs of stakeholders. Organizations
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Master's degree in Interdisciplinary and Innovative Engineering

, 2020
Virtual information session for the Master's degree in Interdisciplinary & Innovative Engineering, a master's degree taught at the Barcelona East School of Engineering (EEBE) at the UPC, with 100% teaching in English. One of the key factors in leading

core   +1 more source

Do External Technology Acquisitions Matter for Innovative Efficiency and Productivity? [PDF]

To quickly adapt to technological change and developments, and thus remain competitive, firms increasingly resort to the use of external technology. This paper investigates whether and to what extent the acquisition of external disembodied technology ...
Tseveen Gantumur, Andreas Stephan
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Kur’an-ı Kerim Öğretiminde Teknolojik İmkânlar ve Kullanımı / Technological Facilities for Teaching the Quran and Their Usage / الإمكانيات التكنولوجية واستخدامها لتدريس القرآن الكريم

İlahiyat Akademi, 2019
Teknolojinin öğretime yönelik katkıları ve öğrenci motivasyonu üzerindeki etkileri hâlâ bir tartışma konusudur. Kur’an-ı Kerîm öğretiminde teknolojik imkânların kullanılması, aktif duyu organlarının etkinliğini artırmakta dolayısı ile öğrenimi ...
Süleyman Kablan
doaj