Results 101 to 110 of about 22,381 (287)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The adaptation of the Innovative Moments Coding System to the group intervention: a preliminary study [PDF]

, 2021
Aims. The Innovative Moment Coding System (IMCS; Gonçalves et al., 2011) is a reliable and valid method originally developed to track markers of change in individual psychotherapy.
Cutolo A. S., Gonçalves M. M., Freda M. F., Passeggia R., Esposito G.   +4 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Relational schemas as mediators of innovative moments in symptom improvement in major depression [PDF]

, 2017
Objectives: Innovative moments (IMs) are exceptions to the maladaptive framework of meaning that typically motivates clients to seek psychotherapy, and previous studies have shown that IMs are associated with psychotherapy outcomes.
Anabela Machado, Batista, João, Gonçalves, Miguel M., Daniela Alves, Silva, Joana, Sousa, Inês, Silva, Joana Ribeiro da, Inês Sousa, Joana Silva, Freitas, Sara, Fernández-Navarro, Pablo, Alves, Daniela, Machado, Anabela, João Batista, Sara Freitas, Miguel M. Gonçalves, Pablo Fernández-Navarro, Magalhães, Carina, Carina Magalhães   +18 more
core   +2 more sources

УПРАВЛЕНИЕ ИННОВАЦИОННЫМИ ПРОЕКТАМИ: ПРИНЦИПЫ И МЕТОДЫ ОЦЕНКИ РИСКОВ

Экономика: стратегия и практика, 2018
For optimal control for the processes of innovation projects management, a theoretical and practical base based on study and improving of existing theories and practices is necessary.
R. S. Aitelenov, A. A. Karaneev
doaj  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Innovative moments and change in cognitive behavioral therapy for bulimia nervosa [PDF]

, 2015
Dissertação de mestrado em Psicologia AplicadaMuitos estudos em torno da eficácia da Terapia Cognitiva Comportamental no tratamento da Bulimia Nervosa têm vindo a ser desenvolvidos.
Fina, Rute Miriam Lopes
core  

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source