Results 81 to 90 of about 22,381 (287)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Three narrative-based coding systems: innovative moments, ambivalence and ambivalence resolution [PDF]

, 2017
Narrative and dialogical perspectives suggest that personal meaning systems’ flexibility is an important resource for change in psychotherapy. Drawn from these theoretical backgrounds, a research program focused on the identification of Innovative ...
Rosa, Catarina Pires da, Navarro-Fernández, Pablo, Gonçalves, Miguel M., Batista, João, Alves, Diana, Braga, Cátia, Silva, Joana Maria Ribeiro, Ribeiro, António P., Oliveira, João Tiago, Mendes, Inês   +9 more
core   +1 more source

A Brief History of the Geography of Education Policy: Ongoing Conversations and Generative Tensions

AERA Open, 2018
In this article, we map the expansion of geographic approaches in education policy scholarship in the last two decades. Our main objective is to trace key contributions, illuminating moments and turns from multiple epistemological perspectives within the
Ee-Seul Yoon, Kalervo Gulson, Christopher Lubienski   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Innovative moments coding system: shorten version: an exploratory study [PDF]

, 2019
Dissertação de mestrado integrado em PsicologiaO principal objetivo deste estudo foi analisar, de uma forma exploratória, se haveria alguma equivalência entre uma versão abreviada do Sistema de Codificação de Momentos de Inovação (SCMI – versão ...
Silva, Joana Meireles e
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

EFFECT OF VANISHING MOMENTS ON THE QUALITY ATTRIBUTES OF AN IMAGE IN DIGITAL WATERMARKING SYSTEM [PDF]

, 2015
Good localisation in time and frequency, perfect compaction of energy are the key features in selecting the transform domain for the analysis of signal.Also,it is known that higher the sparse representation of transforms, better will be the efficiency ...
., Abhilash T B; DEPARTMENT OF DIGITAL ELECTRONICS & COMMUNICATION SYSTEMS VTU-CENTER FOR POST GRADUATION STUDIES, BANGALORE REGION VIAT, MUDDENAHALLI
core  

ASPECTS OF THE HARMONY OF CULTIC CHOIRS FROM OEDIPUS BY GEORGE ENESCU

Studia Universitatis Babeş-Bolyai. Musica, 2011
It approaches to analysis some choral moments of cultic ritual of George Enescu's opera Oedipus, in the light source of inspiration to those of ancient Greek and Byzantine succession.
Constanţa CRISTESCU
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Misspecified heteroskedasticity in the panel probit model: A small sample comparison of GMM and SML estimators [PDF]

This paper compares generalized method of moments (GMM) and simulated maximum likelihood (SML) approaches to the estimation of the panel probit model. Both techniques circumvent multiple integration of joint density functions without the need to restrict
Joachim Inkmann
core