Results 71 to 80 of about 2,058,475 (281)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

AESHML: An Automatic Editing Method for Soccer Match Highlights Using Multimodal Learning

IEEE Access
With the increasing prevalence of short videos, viewers are increasingly seeking concise and engaging segments of video content. In soccer matches, despite the fact that the duration of the match often exceeds 90 minutes, it is the brief highlight ...
Mengjiao Han, Peng Wen, Jie Zhao
doaj   +1 more source

DRIVING IN EMERGENCIES WITH USE OF SYSTEM OF THE HELP TO THE DRIVER

International Journal of Advanced Studies, 2017
The purpose of this article consists in research of modern technologies in automotive industry by the analysis and carrying out technical experiment. The main attention concentrates on traffic safety, which is carried out by automation and modernization ...
Svetlana Alekseevna Vasyugova, Andrey Borisovich Nikolaev   +1 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Addressing microaggressions in racially charged patient-provider interactions: a pilot randomized trial

BMC Medical Education, 2020
Background Racial bias in medical care is a significant public health issue, with increased focus on microaggressions and the quality of patient-provider interactions.
Jonathan W. Kanter, Daniel C. Rosen, Katherine E. Manbeck, Heather M. L. Branstetter, Adam M. Kuczynski, Mariah D. Corey, Daniel W. M. Maitland, Monnica T. Williams   +7 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

ON THE EFFICIENCY OF THE USE OF ONLINE LECTURES AND WEBINARS IN THE TRAINING OF PHARMACOLOGY OF FUTURE PEDIATRICS

RUDN Journal of Informatization in Education, 2018
The article focuses on the fact that in the modern world information technologies are becoming increasingly important. It is important for students of all specialities in higher education institutions.
Olga Vitalievna Polyakova, Galina Sergeevna Mal’, Natalya Vladimirovna Boldina   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A Brief History of the Geography of Education Policy: Ongoing Conversations and Generative Tensions

AERA Open, 2018
In this article, we map the expansion of geographic approaches in education policy scholarship in the last two decades. Our main objective is to trace key contributions, illuminating moments and turns from multiple epistemological perspectives within the
Ee-Seul Yoon, Kalervo Gulson, Christopher Lubienski   +2 more
doaj   +1 more source