Results 71 to 80 of about 22,381 (287)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Ethnic Conflict Management and Deliberative Transformative Moments in Srebrenica, Bosnia and Herzegovina [PDF]

, 2018
The dissertation of Simona Mameli explores the potential for deliberation in deeply divided societies by applying the innovative concept of Deliberative Transformative Moments (DTM) to discussions between conflicting groups - Serbs and Bosnjaks - in the ...
Mameli, Simona
core   +1 more source

DRIVING IN EMERGENCIES WITH USE OF SYSTEM OF THE HELP TO THE DRIVER

International Journal of Advanced Studies, 2017
The purpose of this article consists in research of modern technologies in automotive industry by the analysis and carrying out technical experiment. The main attention concentrates on traffic safety, which is carried out by automation and modernization ...
Svetlana Alekseevna Vasyugova, Andrey Borisovich Nikolaev   +1 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

AESHML: An Automatic Editing Method for Soccer Match Highlights Using Multimodal Learning

IEEE Access
With the increasing prevalence of short videos, viewers are increasingly seeking concise and engaging segments of video content. In soccer matches, despite the fact that the duration of the match often exceeds 90 minutes, it is the brief highlight ...
Mengjiao Han, Peng Wen, Jie Zhao
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Addressing microaggressions in racially charged patient-provider interactions: a pilot randomized trial

BMC Medical Education, 2020
Background Racial bias in medical care is a significant public health issue, with increased focus on microaggressions and the quality of patient-provider interactions.
Jonathan W. Kanter, Daniel C. Rosen, Katherine E. Manbeck, Heather M. L. Branstetter, Adam M. Kuczynski, Mariah D. Corey, Daniel W. M. Maitland, Monnica T. Williams   +7 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

ON THE EFFICIENCY OF THE USE OF ONLINE LECTURES AND WEBINARS IN THE TRAINING OF PHARMACOLOGY OF FUTURE PEDIATRICS

RUDN Journal of Informatization in Education, 2018
The article focuses on the fact that in the modern world information technologies are becoming increasingly important. It is important for students of all specialities in higher education institutions.
Olga Vitalievna Polyakova, Galina Sergeevna Mal’, Natalya Vladimirovna Boldina   +2 more
doaj   +1 more source