Results 31 to 40 of about 163,258 (216)

Spatiotemporal variability and trends in rainfall and temperature in the central highlands of Ethiopia

Scientific African
This study investigates the spatiotemporal variability and trends of rainfall and temperature in the Ejerie district, Ethiopia, focusing on the Dega and Weyina Dega agroecological zones.
Marshet Tefera, Engdawork Assefa, Shiferaw Muleta   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Innovative trend analysis of precipitation changes over Nigeria: A case study of locations across the Niger and Benue Rivers

Journal of Nigerian Society of Physical Sciences
Precipitation has  become a major topic of discussion in the subject of climate change. Studies have presented correlative relationships between climate change and the existing alterations in the global water cycle, leading to more extreme precipitation
Emmanuel P. Agbo, Golden C. Offorson, Abubakar S. Yusuf, John O. Bassey, Moses A. Okono, Ugochukwu Nkajoe, Patrick O. Ushie   +6 more
doaj   +1 more source

Time series data and rainfall pattern subjected to climate change using non-parametric tests over a vulnerable region of Karnataka, India

Journal of Water and Climate Change, 2023
Fluctuations in the precipitation pattern often tend to have an impact on the availability of water, making it necessary to explore spatiotemporal variations in rainfall. This study explores the time series analysis of the rainfall from 1952 to 2019. The
Sanjay Kumar, S. A. Ahmed, Jyothika Karkala   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Combined use of graphical and statistical approaches for rainfall trend analysis in the Mae Klong River Basin, Thailand

Journal of Water and Climate Change, 2023
The main purpose of this paper was to investigate the monthly, seasonal, and annual rainfall variability in the Mae Klong River Basin in Thailand using the Mann–Kendall (MK) test, Sen's slope method, Spearman's Rho (SR) test, and the innovative trend ...
Alamgir Khalil
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Unraveling spatio-temporal rainfall variability in the Tlawng watershed, Mizoram under a tropical monsoon regime

Discover Geoscience
This study provides a comprehensive assessment of the spatiotemporal characteristics and long-term trends in rainfall across the Tlawng watershed in Mizoram, Northeast India, over a 40-year period (1984–2023).
Imanuel Lawmchullova, Joseph Lalngaihawma, A. Lozaanba Khumbah, Lal Rinkimi, Vishwambhar Prasad Sati, Benjamin L. Saitluanga, Gyanendra Konthoujam, Bobby Beingachhi   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source