Results 121 to 130 of about 42,321 (261)

Pulmonary arterial mechanoreceptors mediate sustained sympathoexcitation during high altitude hypoxia in humans

Experimental Physiology, EarlyView.
Abstract Sympathetic nervous system activation is a hallmark of high‐altitude hypoxia, yet the afferent mechanisms remain incompletely defined. We examined the relative contributions of pulmonary arterial mechanoreceptors and carotid chemoreceptors – two excitatory pathways co‐activated by hypoxia – to sustained sympathoexcitation at altitude.
Michiel T. Ewalts, Lydia L. Simpson, Jack S. Talbot, Elliott J. Jenkins, Travis D. Gibbons, Connor A. Howe, Lauren E. Maier, Emily R. Vanden Berg, Alex M. Williams, Philip N. Ainslie, Samuel J. Oliver, Craig D. Steinback, Mike Stembridge, Jonathan P. Moore   +13 more
wiley   +1 more source

Revisiting Niclosamide Formulation Approaches – a Pathway Toward Drug Repositioning

Drug Design, Development and Therapy
Mario Jug,1 Flavia Laffleur,2 Gioconda Millotti3 1Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, 10 000, Croatia; 2Department of Pharmaceutical Technology, Institute of Pharmacy, Center for ...
Jug M, Laffleur F, Millotti G
doaj  

The role of age in choosing high-efficacy treatment for multiple sclerosis: an Austrian MS Database study. [PDF]

J Neurol
Hegen H, Föttinger F, Walde J, Berek K, Martinez-Serrat M, Damulina A, Krajnc N, Ponleitner M, Di Pauli F, Enzinger C, Deisenhammer F, Berger T, Khalil M, Bsteh G, Austrian Multiple Sclerosis Database Study group.   +14 more
europepmc   +1 more source

Daily hot‐water immersion preserves altitude‐induced haemoglobin mass expansion following descent independent of erythropoietin

Experimental Physiology, EarlyView.
Abstract High‐altitude exposure increases haemoglobin mass (Hbmass), a key determinant of arterial oxygen‐carrying capacity, but following descent this adaptation can regress toward baseline within 7 days. Long‐term heat acclimation has emerged as an alternative stimulus for Hbmass expansion; however, whether post‐altitude passive‐heat exposure can ...
Elliott J. Jenkins, Jodie L. Koep, Andrew J. M. Douglas, Lauren E. Maier, Connor A. Howe, Sarah Sheitelman, Liam D. Corr, Christoph Siebenmann, Michael G. Hughes, Joshua C. Tremblay, Philip N. Ainslie, Travis D. Gibbons, Mike Stembridge   +12 more
wiley   +1 more source

Long enduring response on teclistamab in a patient with myeloma relapse after allogeneic hematopoietic stem cell transplantation - a case report. [PDF]

Ann Hematol
Ebner P, Fauser J, Hetzenauer G, Köck S, Willenbacher W, Rossetti LM, Buchwald TA, Rasche L, Gunsilius E, Nachbaur D, Wolf D, Steiner N.   +11 more
europepmc   +1 more source

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

Multimodal imaging and molecular analysis of a 350-year-old purple heron mummy. [PDF]

Sci Rep
Lackner M, Zelger B, Schirmer M, Unterberger SH, Pallua AK, Schäfer G, Sieß M, Brosch I, Zelger B, Degenhart G, Hermann M, Arora R, Klosterhuber M, Parson W, Kustatscher E, Huck CW, Pallua JD.   +16 more
europepmc   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

Impact of postoperative blood pressure management on postoperative hemorrhage after resection of intraparenchymal brain tumors. [PDF]

Acta Neurochir (Wien)
Demetz M, Krigers A, Uribe-Pacheco R, Pinggera D, Klingenschmid J, Thomé C, Freyschlag CF, Kerschbaumer J.   +7 more
europepmc   +1 more source

Effects of nocturnal periodic breathing on sympathetic nerve activity and ventilatory control at high altitude: a randomised, crossover study

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the randomised crossover study investigating the effects of nocturnal periodic breathing (nPB) on sympathetic activity and ventilatory acclimatisation in hypobaric hypoxia equivalent to 4000 m altitude. Participants completed two 3‐day sojourns where nPB was inhibited by increasing inspiratory CO2 fraction ...
Johanna Roche, James P. Fisher, Peter Rasmussen, Abubaker Ibrahim, Philip N. Ainslie, Rachel Turner, Giovanni Vinetti, Matteo Cesari, Michael Furian, Ambra Stefani, Nikolaus Netzer, Hannes Gatterer, Birgit Högl, Christoph Siebenmann   +13 more
wiley   +1 more source