Results 291 to 300 of about 1,019,691 (337)

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

Physiological defensive modes to biologically induce drought tolerance in broccoli via inoculation with mycorrhiza and Trichoderma. [PDF]

BMC Plant Biol
Metwally AA, Riad GS, Ghoname AA, El-Sawy SM, Salama DS, Alkhawaga L, Shahin MG, Saudy HS, AbdelMotlb NA.   +8 more
europepmc   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

Countering AI-generated misinformation with pre-emptive source discreditation and debunking. [PDF]

R Soc Open Sci
Spearing ER, Gile CI, Fogwill AL, Prike T, Swire-Thompson B, Lewandowsky S, Ecker UKH.   +6 more
europepmc   +1 more source

Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker‐Based Drug Screening for Neurodegenerative Diseases

Advanced Science, EarlyView.
This work introduces an on‐chip, integrated plasmonic infrared microarray sensor that enables high‐throughput, label‐free drug screening targeting structural protein biomarkers in neurodegenerative diseases. Through ultra‐compact microwell arrays, the sensor achieves ultra‐sensitive, rapid, and multiplexed secondary structural analysis of the effect of
Deepthy Kavungal, Enzo Morro, Senthil T Kumar, Berkay Dagli, Hilal A Lashuel, Hatice Altug   +5 more
wiley   +1 more source

Proteomic Analysis of Heavy Metal-Induced Toxicity Using the Cellular Slime Mould <i>Dictyostelium discoideum</i>: Effects of Copper Exposure on Aggregation and Protein Expression. [PDF]

Toxics
Itoh A, Kurihara K, Shoji R.
europepmc   +1 more source

Impact of P fertilizer and arbuscular mycorrhizal fungi on forage legume growth, chlorophyll content and productivity. [PDF]

PeerJ
Mpongwana S, Manyevere A, Mpendulo CT, Mupangwa J, Mashece W, Mndela M.   +5 more
europepmc   +1 more source

OsLB2.2 negatively regulates rice disease resistance at seedling stage in rice. [PDF]

Front Plant Sci
Ma T, Wang M, Xie S, Li C, Wang J, Liu H, Yang L, Men L, Sun Z, Zong T, Zou D, Zheng H, Xin W.   +12 more
europepmc   +1 more source