Results 301 to 310 of about 702,869 (343)

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Influence of Plant Growth-Promoting Rhizobacteria (PGPR) Inoculation on Phenolic Content and Key Biosynthesis-Related Processes in <i>Ocimum basilicum</i> Under <i>Spodoptera frugiperda</i> Herbivory. [PDF]

Plants (Basel)
Palermo JS, Palermo TB, Cappellari LDR, Balcke GU, Tissier A, Giordano W, Banchio E.   +6 more
europepmc   +1 more source

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

Screening, Identification, and Fermentation Characteristics of Lactic Acid Bacteria from Pickled Potherb Mustard and Potential Applications. [PDF]

Foods
Kong X, Zhang J, Shen H, Shi N, Zhou H, Li Y, Guo Y, Luo H, Yu L.   +8 more
europepmc   +1 more source

Extravasation of Borrelia burgdorferi Across the Blood–Brain Barrier is an Extremely Rare Event

Advanced Science, EarlyView.
Lyme disease is caused by vascular dissemination of the bacteria Borrelia. In a 3D tissue‐engineered microvessel model, Borrelia extravasation across the blood–brain barrier is extremely rare, implying that neuroborreliosis is not caused via direct cytotoxicity.
Linus Wang, Zikai Xia, Anjan Singh, Bhavna Murarka, Nicole Baumgarth, John N. Aucott, Peter C. Searson   +6 more
wiley   +1 more source

Rhizosphere Growth-Promoting Fungi of Healthy <i>Nicotiana tabacum</i> L.: A Systematic Approach to Boosting Plant Growth and Drought Resistance. [PDF]

Microorganisms
Yin Q, Feng Z, Ren Z, Li A, Jaisi A, Yang M.   +5 more
europepmc   +1 more source

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury

Advanced Science, EarlyView.
Peptidyl arginine deiminase 2 (PAD2) plays a key role in regulating macrophage function in Pseudomonas aeruginosa‐induced acute lung injury (ALI). Using single‐cell RNA sequencing and proteomics, a new PAD2‐catalyzed citrullination site on NF‐κB p65 (171 Arginine), modulating macrophage polarization is identified.
Xin Yu, Yujing Song, Tao Dong, Wenlu Ouyang, Chao Quan, Liujiazi Shao, Leonard Barasa, Paul R. Thompson, Mao Zhang, Jianjie Ma, Katsuo Kurabayashi, Yongqing Li   +11 more
wiley   +1 more source

Effect of Inoculation Volume on a Mouse Model of Influenza Virus Infected with the Same Viral Load. [PDF]

Vaccines (Basel)
Sun Y, Wei Y, Han X, Wang Y, Yin Q, Zhang Y, Yang T, Zhang J, Sun K, Fang F, Zhang S, Yuan K, Li M, Zhao G.   +13 more
europepmc   +1 more source

Random mechanisms govern bacterial succession in bioinoculated beet plants. [PDF]

Sci Rep
Gołębiewski M, Sikora M, Mazur J, Szymańska S, Tyburski J, Hrynkiewicz K, Ulrich W.   +6 more
europepmc   +1 more source

Pathogen-specific stomatal responses in cacao leaves to Phytophthora megakarya and Rhizoctonia solani. [PDF]

Sci Rep
Baek I, Lim S, Jang JH, Hong SM, Prom LK, Kirubakaran S, Cohen SP, Lakshman D, Kim MS, Meinhardt LW, Park S, Ahn E.   +11 more
europepmc   +1 more source