Results 31 to 40 of about 8,158 (216)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

COLD MIXTURE OF INORGANIC BINDER: STATUS AND PROSPECTS OF DEVELOPMENT (INORGANIC VS. ORGANIC)

open access: yesЛитьë и металлургия, 2018
The technologies of molding from cold-hardening mixtures based on organic resins and inorganic metal phosphate binders are compared. The use of the latter is preferable for a number of technological indicators.
S. S. Tkachenko   +3 more
doaj   +1 more source

Performance Evaluation of Crumb Rubber Asphalt Modified with Silicone-Based Warm Mix Additives

open access: yesAdvances in Civil Engineering, 2020
This research was conducted to elucidate better understanding of the performance of crumb rubber asphalt modified with silicone-based warm mix additives. Two different silicone-based warm mix asphalt (WMA) additives (herein Tego XP and Addibit) were used
Nonde Lushinga   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Influence of Technological Parameters of Furane Mixtures on Shrinkage Creation in Ductile Cast Iron Castings

open access: yesArchives of Metallurgy and Materials, 2014
Ductile cast iron (GS) has noticed great development in last decades and its boom has no analogue in history humankind. Ductile iron has broaden the use of castings from cast iron into areas, which where exclusively domains for steel castings.
Vasková I.   +3 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

open access: yesFEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Self‐Cleaning Sensor Surfaces for Long‐Term Environmental Monitoring

open access: yesAdvanced Engineering Materials, EarlyView.
Long‐term use of unattended outdoor sensors without soiling or biofouling is achieved through generation of a micro‐ and nanorough cuvette surface by combing hydrophobic nanoparticles with fluorinated polymers, crosslinked and surface‐attached through CHic chemistry. The coating demonstrates self‐cleaning behavior and prolonged outdoor stability, which
Sanam Kumari Rajak   +4 more
wiley   +1 more source

Feasibility and Limitations of the Advanced Replica Process for Bioactive Glasses

open access: yesAdvanced Engineering Materials, EarlyView.
Periodic 3D‐printed Kelvin‐cell templates enable a controlled advanced replica process for fabricating highly porous glass lattices. Across P45K9, 45S5, and 13–93, material‐dependent differences in coating, burnout, and shrinkage lead to distinct strut morphologies, while comparable final porosities of 83%–88% are retained.
Swantje Funk   +4 more
wiley   +1 more source

Foundry Core Mixtures with Orthophosphoric Acid and Different Aluminum-Containing Compounds

open access: yesФізика і хімія твердого тіла, 2020
The scientific and practical issues of the development of core mixtures for foundry, based on phosphate binding materials, are considered. The binder presented in this article differ from those previously known by the fact that scarce prepared metal ...
R. V. Liutyi   +2 more
doaj   +1 more source

Low Formaldehyde Binders for Mineral Wool Insulation: A Review

open access: yesGlobal Challenges, 2022
Insulating materials are ubiquitous in a built environment and play a critical role in reducing the energy consumed to maintain habitable indoor environments. Mineral wool insulation (MWI) products, including glass, stone, and slag variants, are the most
Thomas M. Bennett   +3 more
doaj   +1 more source

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