Results 121 to 130 of about 107,826,167 (138)

Pharmacological inhibition of host pathways enhances macrophage killing of intracellular bacterial pathogens. [PDF]

Microbiol Spectr
Rijal R, Gomer RH.
europepmc   +1 more source

Inositol hexakisphosphate Functions as a Cofactor and Modulator of ADAR1 Activity

Venegas-Solis F, Lu M, Cohen-Fultheim R, Bender F, Fedeli V, Masunaga T, Fujita M, Zillinger T, Schneider S, Kaufmann A, Saiardi A, Levanon EY, Jessen H, Bauer S.   +13 more
europepmc   +1 more source

Inositol Hexakisphosphate Kinase 1 Maintains Hemostasis in Mice by Regulating Platelet Polyphosphate Levels [PDF]

Blood, 2013
Key Points Inositol hexakisphosphate kinase 1 (IP6K1) knockout mice display lower inorganic polyphosphate levels in platelets. Low platelet polyphosphate leads to lengthened clotting time, altered clot architecture, and protection against pulmonary thromboembolism.
Somadri Ghosh, Dhananajay Shukla, Rashna Bhandari   +2 more
exaly   +4 more sources

Inositol Hexakisphosphate Kinases Differentially Regulate Trafficking of Vesicular Glutamate Transporters 1 and 2

Frontiers in Cellular Neuroscience, 2022
Inositol pyrophosphates have been implicated in cellular signaling and membrane trafficking, including synaptic vesicle (SV) recycling. Inositol hexakisphosphate kinases (IP6Ks) and their product, diphosphoinositol pentakisphosphate (PP-IP5 or IP7), directly and indirectly regulate proteins important in vesicle recycling by the activity-dependent bulk ...
Susan M Voglmaier
exaly   +4 more sources

Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors

ACS Medicinal Chemistry Letters, 2023
A high-throughput fragment-based screen has been employed to discover a series of quinazolinone inositol hexakisphosphate kinase (IP6K) inhibitors. IP6Ks have been studied for their role in glucose homeostasis, metabolic disease, fatty liver disease ...
James Barrow, Dean G Brown, Glen Ernst
exaly   +2 more sources

PiUS (Pi Uptake Stimulator) Is an Inositol Hexakisphosphate Kinase

FEBS Letters, 1999
A cDNA cloned from its ability to stimulate inorganic phosphate uptake in Xenopus oocytes (phosphate uptake stimulator (PiUS)) shows significant similarity with inositol 1,4,5-trisphosphate 3-kinase.
Charles A. Brearley, Jürg Biber, Robin F Irvine   +2 more
exaly   +2 more sources

Inositol Hexakisphosphate Kinase-2 Acts as an Effector of the Vertebrate Hedgehog Pathway

Proceedings of the National Academy of Sciences of the United States of America, 2010
Inositol phosphate (IP) kinases constitute an emerging class of cellular kinases linked to multiple cellular activities. Here, we report a previously uncharacterized cellular function in Hedgehog (Hh) signaling for the IP kinase designated ...
Susan Rae Wente, Bhaskarjyoti Sarmah
exaly   +2 more sources

Gene Deletion of Inositol Hexakisphosphate Kinase 1 Reveals Inositol Pyrophosphate Regulation of Insulin Secretion, Growth, and Spermiogenesis [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2008
Inositol pyrophosphates, also designated inositol diphosphates, possess high-energy β-phosphates that can pyrophosphorylate proteins and regulate various cellular processes. They are formed by a family of inositol hexakisphosphate kinases (IP6Ks). We have created mice with a targeted deletion of IP6K1 in which production of inositol pyrophosphates is ...
Solomon H. Snyder, Adam C Resnick, Rashna Bhandari   +2 more
exaly   +3 more sources

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Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023
Abstract Inositol hexakisphosphate kinases (IP6Ks) are enzymes that catalyse the synthesis of the inositol pyrophosphate 5-IP7 which is involved in the regulation of many physiological processes in mammals. The IP6K paralog IP6K1 is expressed at high levels in the mammalian testis, and its deletion leads to sterility ...
Sameer Ahmed Bhat, Aushaq Bashir Malla, Vineesha Oddi, Jayraj Sen, Rashna Bhandari   +4 more
openaire   +2 more sources

Synthesis of InsP 7 by the Inositol Hexakisphosphate Kinase 1 (IP6K1)

2010
Soluble inositol polyphosphates represent a variegate class of signalling molecules essential for the function of disparate cellular processes. Recently, the phytic acid derivate inositol pyrophosphate, InsP(7) (PP-IP(5) or IP(7)) has been shown to pyro-phosphorylate proteins in a kinase independent way. To begin to understand the functional importance
Cristina, Azevedo, Adam, Burton, Matthew, Bennett, Sara Maria Nancy, Onnebo, Adolfo, Saiardi   +4 more
openaire   +2 more sources