Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability [PDF]
Molecular BrainInositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+/K+
Alfred C Chin, Aili Liu, Weiwei Cheng
exaly +6 more sources
Shaping the Future of Obesity Treatment: In Silico Multi-Modeling of IP6K1 Inhibitors for Obesity and Metabolic Dysfunction [PDF]
PharmaceuticalsRecent research has uncovered a promising approach to addressing the growing global health concern of obesity and related disorders. The inhibition of inositol hexakisphosphate kinase 1 (IP6K1) has emerged as a potential therapeutic strategy.
Amit Kumar Halder +1 more
exaly +7 more sources
Molecular Metabolism, 2017 Objective: IP6 kinases (IP6Ks) regulate cell metabolism and survival. Mice with global (IP6K1-KO) or adipocyte-specific (AdKO) deletion of IP6K1 are protected from diet induced obesity (DIO) at ambient (23 °C) temperature.
Qingzhang Zhu +2 more
exaly +6 more sources
Inositol hexakisphosphate kinase 1 is implicated in the insulin response to protein ingestion in older adults [PDF]
Scientific ReportsAge-related muscle mass is driven by a reduction in insulin sensitivity partly mediated by reduced amino acid and anabolic signalling kinetics. Insulin activates Akt-mTORC1 signalling in skeletal muscle, with inositol hexakisphosphate kinase 1 (IP6K1 ...
Richie D. Barclay +8 more
doaj +3 more sources
Molecular Metabolism, 2021 Objective: Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered that whole-body and adipocyte-specific Ip6k1deletion protects mice from high-fat-diet ...
David A. Ford +2 more
exaly +5 more sources
Inositol hexakisphosphate kinases differentially regulate trafficking of vesicular glutamate transporters 1 and 2 [PDF]
Frontiers in Cellular Neuroscience, 2022 Inositol pyrophosphates have been implicated in cellular signaling and membrane trafficking, including synaptic vesicle (SV) recycling. Inositol hexakisphosphate kinases (IP6Ks) and their product, diphosphoinositol pentakisphosphate (PP-IP5 or IP7 ...
Haiyan Li +3 more
doaj +2 more sources
The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System [PDF]
Biomolecules, 2023 Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with the kinases and phosphatases that interconvert ...
Tyler Heitmann, James C. Barrow
doaj +2 more sources
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor [PDF]
eLife, 2023 Inositol hexakisphosphate kinases (IP6Ks) are emerging as relevant pharmacological targets because a multitude of disease-related phenotypes has been associated with their function.
Tim Aguirre +8 more
doaj +2 more sources
Pharmacological Inhibition of Inositol Hexakisphosphate Kinase 1 Protects Mice against Obesity-Induced Bone Loss [PDF]
Biology, 2022 Obesity and type II diabetes mellitus (T2DM) are prominent risk factors for secondary osteoporosis due to the negative impacts of hyperglycemia and excessive body fat on bone metabolism.
Siddaraju V. Boregowda +6 more
doaj +2 more sources
The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling [PDF]
Biomolecules, 2023 Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently needed.
Sandip Mukherjee +7 more
doaj +2 more sources