Deletion of IP6K1 in mice accelerates tumor growth by dysregulating the tumor-immune microenvironment [PDF]
Animal Cells and Systems, 2022 A family of inositol hexakisphosphate kinases (IP6Ks) catalyzes the production of inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate) which is known to modulate various biological events such as cell growth. While targeting IP6K1 in various
Haein Lee +4 more
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Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis [PDF]
Molecular Metabolism, 2021 Objective: Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered that whole-body and adipocyte-specific Ip6k1deletion protects mice from high-fat-diet ...
Sandip Mukherjee +13 more
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Molecular modeling, dynamics simulation and characterization of human inositol hexakisphosphate kinase 1 (IP6K1) related to diabetes [PDF]
Journal of Applied Sciences and Environmental Management, 2019 Inositol hexakisphosphate kinase-1 (IP6K1) protein plays an important role in insulin signaling producing IP7 that inhibit the action of protein kinase B (Akt).
O.O. Elekofehinti +4 more
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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor [PDF]
eLife, 2023 Inositol hexakisphosphate kinases (IP6Ks) are emerging as relevant pharmacological targets because a multitude of disease-related phenotypes has been associated with their function.
Tim Aguirre +8 more
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Inositol hexakisphosphate kinases differentially regulate trafficking of vesicular glutamate transporters 1 and 2 [PDF]
Frontiers in Cellular Neuroscience, 2022 Inositol pyrophosphates have been implicated in cellular signaling and membrane trafficking, including synaptic vesicle (SV) recycling. Inositol hexakisphosphate kinases (IP6Ks) and their product, diphosphoinositol pentakisphosphate (PP-IP5 or IP7 ...
Haiyan Li +3 more
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Inositols in Insulin Signaling and Glucose Metabolism [PDF]
International Journal of Endocrinology, Volume 2018, Issue 1, 2018., 2018 In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of
Bevilacqua, Arturo, Bizzarri, Mariano
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Inositol hexakisphosphate kinase 1 is implicated in the insulin response to protein ingestion in older adults [PDF]
Scientific ReportsAge-related muscle mass is driven by a reduction in insulin sensitivity partly mediated by reduced amino acid and anabolic signalling kinetics. Insulin activates Akt-mTORC1 signalling in skeletal muscle, with inositol hexakisphosphate kinase 1 (IP6K1 ...
Richie D. Barclay +8 more
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The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System [PDF]
Biomolecules, 2023 Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with the kinases and phosphatases that interconvert ...
Tyler Heitmann, James C. Barrow
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Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2014 Richard WA Mackenzie, Bradley T Elliott Department of Human and Health Sciences, Facility of Science and Technology, University of Westminster, London, UK Abstract: Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin ...
Mackenzie RWA, Elliott BT
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Pharmacological Inhibition of Inositol Hexakisphosphate Kinase 1 Protects Mice against Obesity-Induced Bone Loss [PDF]
Biology, 2022 Obesity and type II diabetes mellitus (T2DM) are prominent risk factors for secondary osteoporosis due to the negative impacts of hyperglycemia and excessive body fat on bone metabolism.
Siddaraju V. Boregowda +6 more
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