Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability [PDF]
Molecular BrainInositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+/K+
Hongfu Jin, Alfred C Chin, Chenglai Fu
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Shaping the Future of Obesity Treatment: In Silico Multi-Modeling of IP6K1 Inhibitors for Obesity and Metabolic Dysfunction [PDF]
PharmaceuticalsRecent research has uncovered a promising approach to addressing the growing global health concern of obesity and related disorders. The inhibition of inositol hexakisphosphate kinase 1 (IP6K1) has emerged as a potential therapeutic strategy.
Amit Kumar Halder +2 more
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Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis [PDF]
Molecular Metabolism, 2021 Objective: Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered that whole-body and adipocyte-specific Ip6k1deletion protects mice from high-fat-diet ...
Sandip Mukherjee +2 more
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Deletion of IP6K1 in mice accelerates tumor growth by dysregulating the tumor-immune microenvironment [PDF]
Animal Cells and Systems, 2022 A family of inositol hexakisphosphate kinases (IP6Ks) catalyzes the production of inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate) which is known to modulate various biological events such as cell growth. While targeting IP6K1 in various
Haein Lee +4 more
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Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-InsP7 [PDF]
Bioscience Reports, 2023 Abstract Inositol pyrophosphates (PP-IPs) are a sub-family of water soluble inositol phosphates that possess one or more diphosphate groups. PP-IPs can transfer their β-phosphate group to a phosphorylated Ser residue to generate pyrophosphorylated Ser. This unique post-translational modification occurs on Ser residues
Rashna Bhandari +2 more
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Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I [PDF]
Metabolism: Clinical and ExperimentalAtherosclerotic cardiovascular diseases are the leading cause of death. Apolipoprotein A-I (apoA-I) mediates cholesterol efflux to lower the risks of atherosclerosis. Elevating circulating apoA-I is an effective strategy for atheroprotection. However, the regulatory mechanisms of apoA-I have been elusive.Protein-protein interactions were examined by co-
Liu X +15 more
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Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase [PDF]
Journal of Biological Chemistry, 2022 ABSTRACT Inositol is an essential metabolite that serves as a precursor for structural and signaling molecules. Although perturbation of inositol homeostasis has been implicated in numerous human disorders, surprisingly little is known about how inositol levels are regulated in mammalian cells. A recent study in mouse
Pablo Lazcano +2 more
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Molecular Metabolism, 2017 Objective: IP6 kinases (IP6Ks) regulate cell metabolism and survival. Mice with global (IP6K1-KO) or adipocyte-specific (AdKO) deletion of IP6K1 are protected from diet induced obesity (DIO) at ambient (23 °C) temperature.
Qingzhang Zhu +2 more
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Inositol hexakisphosphate kinase 1 is implicated in the insulin response to protein ingestion in older adults [PDF]
Scientific ReportsAge-related muscle mass is driven by a reduction in insulin sensitivity partly mediated by reduced amino acid and anabolic signalling kinetics. Insulin activates Akt-mTORC1 signalling in skeletal muscle, with inositol hexakisphosphate kinase 1 (IP6K1 ...
Richie D. Barclay +8 more
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Inositol hexakisphosphate kinases differentially regulate trafficking of vesicular glutamate transporters 1 and 2 [PDF]
Frontiers in Cellular Neuroscience, 2022 Inositol pyrophosphates have been implicated in cellular signaling and membrane trafficking, including synaptic vesicle (SV) recycling. Inositol hexakisphosphate kinases (IP6Ks) and their product, diphosphoinositol pentakisphosphate (PP-IP5 or IP7 ...
Haiyan Li +3 more
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