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Role of Inositols and Inositol Phosphates in Energy Metabolism [PDF]

open access: yesMolecules, 2020
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Chantacha Sitticharoon   +2 more
exaly   +8 more sources

Bioactivity of Inositol Phosphates [PDF]

open access: yesMolecules, 2021
Inositol phosphates (IPs) are a huge and complex family of biomolecules, important in regulating vital cellular functions, signal transduction, energy transmission, and ion channels physiology and serving as structural components of cell membranes [...]
Ivana Vucenik
doaj   +5 more sources

Analytical Methods for Determination of Phytic Acid and Other Inositol Phosphates: A Review [PDF]

open access: yesMolecules, 2020
From the early precipitation-based techniques, introduced more than a century ago, to the latest development of enzymatic bio- and nano-sensor applications, the analysis of phytic acid and/or other inositol phosphates has never been a straightforward ...
Gregor Marolt, Mitja Kolar
doaj   +3 more sources

Inositol Phosphates Purification Using Titanium Dioxide Beads [PDF]

open access: yesBio-Protocol, 2018
Inositol phosphates (IPs) comprise a family of ubiquitous eukaryotic signaling molecules. They have been linked to the regulation of a pleiotropy of important cellular activities, but low abundance and detection difficulties have hampered our ...
Miranda Wilson, Adolfo Saiardi
doaj   +3 more sources

Inositol phosphates in the environment [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2002
The inositol phosphates are a group of organic phosphorus compounds found widely in the natural environment, but that represent the greatest gap in our understanding of the global phosphorus cycle. They exist as inositols in various states of phosphorylation (bound to between one and six phosphate groups) and isomeric forms (e.g.
Philip Haygarth   +2 more
exaly   +4 more sources

Inositol Phosphates and Synthesizing Enzymes: Implications in Neurodegenerative Disorders [PDF]

open access: yesBiomolecules
Inositol is a vital sugar molecule involved in numerous signaling pathways required for cellular homeostasis and cell survival. Myo-inositol and its phospho-derivatives, inositol phosphates (IPs), are the most prevalent forms of inositol found in living ...
Miriam Greenberg   +2 more
exaly   +4 more sources

Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers [PDF]

open access: yesNature Communications, 2020
Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate ...
Antonia E. Schantl   +21 more
doaj   +3 more sources

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates [PDF]

open access: yesNature Communications, 2016
Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically driven
Peter J. Watson   +9 more
doaj   +3 more sources

SnapShot: Inositol phosphates. [PDF]

open access: yesCell, 2010
Inositol diphosphates can transfer phosphatenonenzymatically to phosphoserine to generate diphosphate modi˜ed proteinsIP6K1 (KCS1) generated inositol diphosphatesare required for proper regulation of telomere lengthIpk2 regulates activity of Swi/Snf and Ino80chromatin-remodeling complexes in yeastIP6K1 (KCS1) is required for proper vacuole morphology ...
Hatch AJ, York JD.
europepmc   +4 more sources

Phytate (Inositol Hexakisphosphate) in Soil and Phosphate Acquisition from Inositol Phosphates by Higher Plants. A Review [PDF]

open access: yesPlants, 2015
Phosphate (P) fixation to the soil solid phase is considered to be important for P availability and is often attributed to the strong binding of orthophosphate anion species.
Jörg Gerke
doaj   +3 more sources

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