Results 41 to 50 of about 828,541 (175)

Inositol metabolism as a broad-spectrum antiviral target

Frontiers in Microbiology
Inositol plays many important roles in cellular processes through its various derivatives including phosphatidylinositol phosphates. Viruses use phosphatidylinositol phosphates for their replication in multiple processes including entry, formation of ...
Kunlakanya Jitobaom, Kunlakanya Jitobaom, Prasert Auewarakul, Prasert Auewarakul   +3 more
doaj   +1 more source

The Impact of Mash pH and Exogenous Phosphorolytic Enzymes on the Release of Inositol Phosphates, Fermentable Sugars and Polypeptide Profile in the Technology of Buckwheat Beer

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology, 2022
The first - already published - stage of the project, which conducted optimization of the temperature mashing program, yielded promising results in the form of an increase in the pool of bioactive myo-inositol by 50% in buckwheat wort supplemented with ...
Robert DULIŃSKI, Dagmara PONIEWSKA
doaj   +1 more source

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family

Biochemistry, 2016
The inositol polyphosphate 5-phosphatase INPP5B hydrolyzes the 5-phosphate group from water- and lipid-soluble signaling messengers. Two synthetic benzene and biphenyl polyphosphates (BzP/BiPhPs), simplified surrogates of inositol phosphates and ...
S. J. Mills, C. Silvander, G. Cozier, L. Trésaugues, P. Nordlund, B. V. Potter   +5 more
semanticscholar   +1 more source

Inositol pyrophosphates: why so many phosphates?

Advances in Biological Regulation, 2014
The inositol pyrophosphates (PP-InsPs) are a specialized group of “energetic” signaling molecules found in yeasts, plants and animals. PP-InsPs boast the most crowded three dimensional phosphate arrays found in Nature; multiple phosphates and ...
S. Shears
semanticscholar   +1 more source

Inositol Phosphates and their Biological Effects

, 2014
The paper is dedicated to data analysis on inositol phosphates nature distribution, structure and biological functions as well as enzymes phytases capable to hydrolyze these hardly digestible compounds and their complexes.
N. Balaban, A. D. Suleimanova, L. Valeeva, I. Chastukhina, M. R. Sharipova   +4 more
semanticscholar   +1 more source

Elucidation of Inverse Agonist Activity of Bilastine

Pharmaceutics, 2020
H1-antihistamines antagonize histamine and prevent it from binding to the histamine H1 receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity.
Hiroyuki Mizuguchi, Tomoharu Wakugawa, Hisato Sadakata, Seiichiro Kamimura, Mai Takemoto, Tomomi Nakagawa, Masami Yabumoto, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui   +9 more
doaj   +1 more source

Group-specific cellular metabolism in Medulloblastoma

Journal of Translational Medicine, 2023
Background Cancer metabolism influences multiple aspects of tumorigenesis and causes diversity across malignancies. Although comprehensive research has extended our knowledge of molecular subgroups in medulloblastoma (MB), discrete analysis of metabolic ...
Viktoria L. E. Funke, Carolin Walter, Viktoria Melcher, Lanying Wei, Sarah Sandmann, Marc Hotfilder, Julian Varghese, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Martin Mynarek, Stefan Rutkowski, Jochen Seggewiss, Daniela Jeising, Flavia W. de Faria, Thorsten Marquardt, Thomas K. Albert, Ulrich Schüller, Kornelius Kerl   +20 more
doaj   +1 more source

The Genetic Background of Abnormalities in Metabolic Pathways of Phosphoinositides and Their Linkage with the Myotubular Myopathies, Neurodegenerative Disorders, and Carcinogenesis

Biomolecules, 2023
Myo-inositol belongs to one of the sugar alcohol groups known as cyclitols. Phosphatidylinositols are one of the derivatives of Myo-inositol, and constitute important mediators in many intracellular processes such as cell growth, cell differentiation ...
Maria Derkaczew, Piotr Martyniuk, Robert Hofman, Krzysztof Rutkowski, Adam Osowski, Joanna Wojtkiewicz   +5 more
doaj   +1 more source

The inositol phosphate signalling network in physiology and disease.

TIBS -Trends in Biochemical Sciences. Regular ed
Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs).
Seyun Kim, R. Bhandari, Charles A. Brearley, A. Saiardi   +3 more
semanticscholar   +1 more source

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores

Journal of Experimental Medicine, 1985
Antibodies against the T3-antigen receptor complex can activate the human T cell line, Jurkat, to produce interleukin 2 (2-5). This activation is initiated by a receptor-mediated increase in the concentration of free cytoplasmic calcium ions [Ca2+]i (3 ...
J. Imboden, J. Stobo
semanticscholar   +1 more source