Insights into the activation mechanism of class I HDAC complexes by inositol phosphates [PDF]
Nature Communications, 2016 Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically driven
Peter J. Watson +9 more
doaj +3 more sources
Inositol phosphates in the environment [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2002 The inositol phosphates are a group of organic phosphorus compounds found widely in the natural environment, but that represent the greatest gap in our understanding of the global phosphorus cycle. They exist as inositols in various states of phosphorylation (bound to between one and six phosphate groups) and isomeric forms (e.g.
Turner, B. L. +3 more
openaire +4 more sources
Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers [PDF]
Nature Communications, 2020 Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate ...
Antonia E. Schantl +21 more
doaj +2 more sources
The intracellular inositol (pyro)phosphate receptor AtSPX1 reciprocally binds to P1BS DNA [PDF]
Nature CommunicationsThe response of plants to phosphate starvation engages PHR (CC-MYB-PHOSPHATE STARVATION RESPONSE) transcription factors that bind to P1BS (GNATATNC) promoter elements of phosphate-starvation induced (PSI) genes. The encoded proteins include single-domain
Hayley L. Whitfield +6 more
doaj +2 more sources
Protein pyrophosphorylation by inositol phosphates: a novel post-translational modification in plants? [PDF]
Frontiers in Plant ScienceInositol pyrophosphates (PP-InsPs) are energy-rich molecules harboring one or more diphosphate moieties. PP-InsPs are found in all eukaryotes evaluated and their functional versatility is reflected in the various cellular events in which they take part ...
Yeshambel Emewodih Mihiret +2 more
doaj +2 more sources
Metabolism of inositol derivatives by the gut microbiome [PDF]
Gut MicrobesThe gut microbiome harbors immense metabolic capacity, much of which is still being uncovered. Recent discoveries have highlighted the ability of gut microbes to metabolize inositol-derived compounds, including free inositols and their phosphorylated ...
Henning Jessen, Thi Phuong Nam Bui
doaj +2 more sources
Phytate (Inositol Hexakisphosphate) in Soil and Phosphate Acquisition from Inositol Phosphates by Higher Plants. A Review [PDF]
Plants, 2015 Phosphate (P) fixation to the soil solid phase is considered to be important for P availability and is often attributed to the strong binding of orthophosphate anion species.
Jörg Gerke
doaj +2 more sources
Simultaneous HPLC determination of soluble signaling molecules and metabolic status in neuroblastoma cell cultures [PDF]
Physiological ReportsSeveral laboratories have explored the capacity of the anion exchange chromatography method in evaluating distinct forms of inositol phosphates in a single analytical process.
Natalie Chaves Ferreira +2 more
doaj +2 more sources
Phytase dose-dependent response of kidney inositol phosphate levels in poultry
PLoS ONE, 2022 Phytases, enzymes that degrade phytate present in feedstuffs, are widely added to the diets of monogastric animals. Many studies have correlated phytase addition with improved animal productivity and a subset of these have sought to correlate animal ...
Colleen Sprigg +5 more
doaj +2 more sources
PLoS ONE, 2023 Inert digestibility index markers such as titanium dioxide are universally accepted to provide simple measurement of digestive tract retention and relative digestibility in poultry feeding trials.
Colleen Sprigg +5 more
doaj +3 more sources