Inositol Phosphates and Retroviral Assembly: A Cellular Perspective [PDF]
Viruses, 2021 Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been ...
Clifton L. Ricaña, Robert A. Dick
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Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis [PDF]
Molecules, 2020 Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including
Samuel E. Weinberg +4 more
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ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Inositol phosphates (IPs) are a class of signaling molecules regulating cell physiology. The best-characterized IP, the calcium release factor IP3, is generated by phospholipase C hydrolysis of phosphoinositides lipids.
Desfougères Y +4 more
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Inositol phosphates are assembly co-factors for HIV-1. [PDF]
Nature, 2018 A short, 14-amino-acid segment called SP1, located in the Gag structural protein1, has a critical role during the formation of the HIV-1 virus particle.
Dick RA +11 more
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A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine [PDF]
Open Biology, 2015 Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions for them, the biochemistry behind these roles is often not fully characterized.
Miranda S. C. Wilson +4 more
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Effect of Phytate (InsP6) and Other Inositol-Phosphates (InsP5, InsP4, InsP3, InsP2) on Crystallization of Calcium Oxalate, Brushite, and Hydroxyapatite [PDF]
Biomolecules, 2023 Pathological calcifications may consist of calcium oxalate (CaOx), hydroxyapatite (HAP), and brushite (BRU). The objective of this study was to evaluate the effect of phytate (inositol hexakisphosphate, InsP6), InsP6 hydrolysates, and individual lower ...
Paula Calvó +2 more
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Nature Communications, 2020 Myo-Inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) are important second messengers but their analysis remains challenging. Here, the authors develop a capillary electrophoresis-mass spectrometry method for the identification and quantitation ...
Danye Qiu +14 more
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Class I HDACs share a common mechanism of regulation by inositol phosphates. [PDF]
Mol Cell, 2013 Summary Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate corepressor proteins into specific transcriptional repression complexes that target HDAC activity to chromatin resulting in chromatin condensation and transcriptional
Millard CJ +7 more
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Towards Improved Bioavailability of Cereal Inositol Phosphates, Myo-Inositol and Phenolic Acids [PDF]
MoleculesCereals are among the foods rich in myo-inositol hexakisphosphate (phytic acid, IP6), lower myo-inositol phosphates (IPx), a wide range of phenolic compounds, as well as vitamins, minerals, oligosaccharides, phytosterols and para-aminobenzoic acid, and ...
Krzysztof Żyła, Aleksandra Duda
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Defining signal transduction by inositol phosphates. [PDF]
Subcell Biochem, 2012 Ins(1,4,5)P3 is a classical intracellular messenger: stimulus-dependent changes in its levels elicits biological effects through its release of intracellular Ca2+ stores.
Shears SB +7 more
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