Platelet IP6K1 regulates neutrophil extracellular trap–microparticle complex formation in acute pancreatitis [PDF]
JCI Insight, 2021 Platelet inositol hexakisphosphate kinase 1 (IP6K1) has been shown to control systemic inflammation. Herein, we examined if platelets and IP6K1 regulate pancreatic tissue injury via formation of NETs in experimental models of acute pancreatitis (AP) in mice.
Raeh Madhi +7 more
doaj +7 more sources
The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System [PDF]
Biomolecules, 2023 Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with the kinases and phosphatases that interconvert ...
Tyler Heitmann, James C. Barrow
doaj +2 more sources
Pharmacological Inhibition of Inositol Hexakisphosphate Kinase 1 Protects Mice against Obesity-Induced Bone Loss [PDF]
Biology, 2022 Obesity and type II diabetes mellitus (T2DM) are prominent risk factors for secondary osteoporosis due to the negative impacts of hyperglycemia and excessive body fat on bone metabolism.
Siddaraju V. Boregowda +6 more
doaj +2 more sources
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor [PDF]
eLife, 2023 Inositol hexakisphosphate kinases (IP6Ks) are emerging as relevant pharmacological targets because a multitude of disease-related phenotypes has been associated with their function.
Tim Aguirre +8 more
doaj +2 more sources
The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling [PDF]
Biomolecules, 2023 Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently needed.
Sandip Mukherjee +7 more
doaj +2 more sources
Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia [PDF]
Science Translational Medicine, 2018 IP6K1-mediated polyP production by platelets promotes neutrophil-platelet aggregation and neutrophil accumulation in bacterial pneumonia.
Qingming Hou +2 more
exaly +3 more sources
The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function. [PDF]
J Am Soc NephrolSignificance Statement Kidneys are gatekeepers of systemic inorganic phosphate balance because they control urinary phosphate excretion. In yeast and plants, inositol hexakisphosphate kinases (IP6Ks) are central to regulate phosphate metabolism, whereas their role in mammalian phosphate homeostasis is mostly unknown.
Haykir B +12 more
europepmc +4 more sources
Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells* [PDF]
Journal of Biological Chemistry, 2016 myo-Inositol, the precursor of all inositol compounds, has pivotal roles in cell metabolism and signaling pathways. Although physiological studies indicate a strong correlation between abnormal intracellular inositol levels and neurological disorders, very little is known about the regulation of inositol synthesis in mammalian cells.
Cunqi Ye, Miriam L Greenberg
exaly +3 more sources
Journal of Cell Science, 2021 ABSTRACT Inositol hexakisphosphate kinase 1 (IP6K1) is a small molecule kinase that catalyzes the conversion of the inositol phosphate IP6 to 5-IP7. We show that IP6K1 acts independently of its catalytic activity to upregulate the formation of processing bodies (P-bodies), which are cytoplasmic ribonucleoprotein granules that store ...
Akruti Shāh +2 more
exaly +3 more sources
Insights into the roles of inositol hexakisphosphate kinase 1 (IP6K1) in mammalian cellular processes. [PDF]
J Biol ChemInositol phosphates and their metabolites play a significant role in several biochemical pathways, gene expression regulation, and phosphate homeostasis. Among the different inositol phosphates, inositol hexakisphosphate (IP6) is a substrate of inositol hexakisphosphate kinases (IP6Ks), which phosphorylate one or more of the IP6 phosphate groups ...
Chakkour M, Greenberg ML.
europepmc +3 more sources