Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I [PDF]
Metabolism: Clinical and ExperimentalAtherosclerotic cardiovascular diseases are the leading cause of death. Apolipoprotein A-I (apoA-I) mediates cholesterol efflux to lower the risks of atherosclerosis. Elevating circulating apoA-I is an effective strategy for atheroprotection. However, the regulatory mechanisms of apoA-I have been elusive.Protein-protein interactions were examined by co-
Liu X +15 more
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Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-InsP7 [PDF]
Bioscience Reports, 2023 Abstract Inositol pyrophosphates (PP-IPs) are a sub-family of water soluble inositol phosphates that possess one or more diphosphate groups. PP-IPs can transfer their β-phosphate group to a phosphorylated Ser residue to generate pyrophosphorylated Ser. This unique post-translational modification occurs on Ser residues
Aisha Hamid +2 more
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Deletion of IP6K1 in mice accelerates tumor growth by dysregulating the tumor-immune microenvironment [PDF]
Animal Cells and Systems, 2022 A family of inositol hexakisphosphate kinases (IP6Ks) catalyzes the production of inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate) which is known to modulate various biological events such as cell growth. While targeting IP6K1 in various
Haein Lee +4 more
doaj +4 more sources
Molecular modeling, dynamics simulation and characterization of human inositol hexakisphosphate kinase 1 (IP6K1) related to diabetes [PDF]
Journal of Applied Sciences and Environmental Management, 2019 Inositol hexakisphosphate kinase-1 (IP6K1) protein plays an important role in insulin signaling producing IP7 that inhibit the action of protein kinase B (Akt).
O.O. Elekofehinti +4 more
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Molecular Metabolism, 2016 Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration.
Sarbani Ghoshal +10 more
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The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function. [PDF]
J Am Soc NephrolSignificance Statement Kidneys are gatekeepers of systemic inorganic phosphate balance because they control urinary phosphate excretion. In yeast and plants, inositol hexakisphosphate kinases (IP6Ks) are central to regulate phosphate metabolism, whereas their role in mammalian phosphate homeostasis is mostly unknown.
Haykir B +12 more
europepmc +7 more sources
IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids [PDF]
Journal of Cell Science, 2017 ABSTRACT Inositol hexakisphosphate kinases (IP6Ks) are enzymes that synthesise the inositol pyrophosphate 5-diphosphoinositol pentakisphosphate (5-IP7), which is known to regulate several physiological processes. Deletion of IP6K1, but not other IP6K isoforms, causes sterility in male mice.
Aushaq Bashir Malla, Rashna Bhandari
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Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase [PDF]
Journal of Biological Chemistry, 2022 ABSTRACT Inositol is an essential metabolite that serves as a precursor for structural and signaling molecules. Although perturbation of inositol homeostasis has been implicated in numerous human disorders, surprisingly little is known about how inositol levels are regulated in mammalian cells. A recent study in mouse
Miriam L Greenberg +2 more
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High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity in glucose intolerant individuals [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2018 Context Insulin resistance in skeletal muscle contributes to whole body hyperglycaemia and the secondary complications associated with type 2 diabetes. Inositol hexakisphosphate kinase-1 (IP6K1) may inhibit insulin-stimulated glucose transport in this tissue type.
Naufau, Jane +7 more
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IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution [PDF]
Stem Cells, 2017 Abstract Mesenchymal stem/stromal cells (MSCs) are the predominant source of bone and adipose tissue in adult bone marrow and play a critical role in skeletal homeostasis. Age-induced changes in bone marrow favor adipogenesis over osteogenesis leading to skeletal involution and increased marrow adiposity so pathways that prevent MSC ...
Siddaraju V. Boregowda +5 more
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