Results 11 to 20 of about 1,062 (145)

Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability [PDF]

Molecular Brain
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+/K+
Hongfu Jin, Aili Liu, Alfred C. Chin, Chenglai Fu, Hui Shen, Weiwei Cheng   +5 more
doaj   +4 more sources

Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I. [PDF]

Metabolism
Background and aims: Atherosclerotic cardiovascular diseases are the leading cause of death. Apolipoprotein A-I (apoA-I) mediates cholesterol efflux to lower the risks of atherosclerosis.
Liu X, Zhang Z, Aguirre T, Shipton ML, Fu L, Du J, Furkert D, Qi J, Chin AC, Riley AM, Liu T, Zhang X, Potter BVL, Fiedler D, Zhu Y, Fu C.   +15 more
europepmc   +5 more sources

Shaping the Future of Obesity Treatment: In Silico Multi-Modeling of IP6K1 Inhibitors for Obesity and Metabolic Dysfunction [PDF]

Pharmaceuticals
Recent research has uncovered a promising approach to addressing the growing global health concern of obesity and related disorders. The inhibition of inositol hexakisphosphate kinase 1 (IP6K1) has emerged as a potential therapeutic strategy.
Ismail Mondal, Amit Kumar Halder, Nirupam Pattanayak, Sudip Kumar Mandal, Maria Natalia D. S. Cordeiro   +4 more
doaj   +4 more sources

The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling [PDF]

Biomolecules, 2023
Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently needed.
Sandip Mukherjee, Molee Chakraborty, Jake Haubner, Glen Ernst, Michael DePasquale, Danielle Carpenter, James C. Barrow, Anutosh Chakraborty   +7 more
doaj   +2 more sources

Integrin-associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients [PDF]

The Journal of Physiology, Volume 598, Issue 24, Page 5701-5716, 15 December 2020., 2020
Key points: Patients with renal failure undergoing maintenance haemodialysis are associated with insulin resistance and protein metabolism dysfunction. Novel research suggests that disruption to the transmembrane protein linkage between the cytoskeleton ...
Ancu, Oana, Burd, Nicholas A., Draicchio, Fulvia, Mackenzie, Richard, Mickute, Monica, Paluska, Scott, Renshaw, Derek, Sathyapalan, Thozhukat, Sylow, Lykke, van Vliet, Stephan, Watt, Peter, Wilund, Kenneth   +11 more
core   +4 more sources

Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain

Molecular Metabolism, 2017
Objective: IP6 kinases (IP6Ks) regulate cell metabolism and survival. Mice with global (IP6K1-KO) or adipocyte-specific (AdKO) deletion of IP6K1 are protected from diet induced obesity (DIO) at ambient (23 °C) temperature.
Qingzhang Zhu, Sarbani Ghoshal, Richa Tyagi, Anutosh Chakraborty   +3 more
doaj   +3 more sources

High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity in glucose intolerant individuals [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2017
Context Insulin resistance in skeletal muscle contributes to whole body hyperglycaemia and the secondary complications associated with type 2 diabetes.
Dunning-Foreman, P., Dunning-Foreman, P., Elliott, B., Elliott, B., Howard, D., Howard, D., Mackenzie, R.W.A., Mackenzie, R.W.A., Markiv, A., Markiv, A., McGrady, M., McGrady, M., Naufahu, J., Naufahu, J., Watt, P.W., Watt, P.W.   +15 more
core   +9 more sources

The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle [PDF]

Frontiers in Nutrition, 2019
Sarcopenia is defined as the combined loss of skeletal muscle strength, function, and/or mass with aging. This degenerative loss of muscle mass is associated with poor quality of life and early mortality humans.
Richie D. Barclay, Nicholas A. Burd, Christopher Tyler, Neale A. Tillin, Richard W. Mackenzie   +4 more
doaj   +3 more sources

Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin. [PDF]

Cardiovasc Res
Aims Adiponectin is an adipocyte-derived circulating protein that exerts cardiovascular and metabolic protection. Due to the futile degradation of endogenous adiponectin and the challenges of exogenous administration, regulatory mechanisms of adiponectin
Fu L, Du J, Furkert D, Shipton ML, Liu X, Aguirre T, Chin AC, Riley AM, Potter BVL, Fiedler D, Zhang X, Zhu Y, Fu C.   +12 more
europepmc   +3 more sources

Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Inositol polyphosphates (IPs) are a group of inositol metabolites that act as secondary messengers for external signalling cues. They play various physiological roles such as insulin release, telomere length maintenance, cell metabolism, and aging ...
Myunghwan Ahn, Seung Eun Park, Jiyeon Choi, Jiahn Choi, Doyoung Choi, Dongju An, Hayoung Jeon, Soowhan Oh, Kiho Lee, Jaehoon Kim, Jaebong Jang, Seyun Kim, Youngjoo Byun   +12 more
doaj   +2 more sources