Results 31 to 40 of about 1,062 (145)

Insights into the roles of inositol hexakisphosphate kinase 1 (IP6K1) in mammalian cellular processes. [PDF]

J Biol Chem
Inositol phosphates and their metabolites play a significant role in several biochemical pathways, gene expression regulation, and phosphate homeostasis. Among the different inositol phosphates, inositol hexakisphosphate (IP6) is a substrate of inositol hexakisphosphate kinases (IP6Ks), which phosphorylate one or more of the IP6 phosphate groups ...
Chakkour M, Greenberg ML.
europepmc   +3 more sources

Potential therapies targeting nuclear metabolic regulation in cancer

MedComm, Volume 4, Issue 6, December 2023., 2023
1. Cell metabolism and gene control are significantly integrated and regulated by one another. 2. There is a positive feedback loop of metabolism‐epigenetics‐gene regulation which control cancer progression. 3. The discovery of metabolic enzymes and their functions in the nucleus will provide more insights into cancer therapy.
Yanjie Chen, Jie Xu, Xiaoyi Liu, Linlin Guo, Ping Yi, Chunming Cheng   +5 more
wiley   +1 more source

RNA‐Seq‐based discovery of genetic variants and allele‐specific expression of two layer lines and broiler chicken

Evolutionary Applications, Volume 16, Issue 6, Page 1135-1153, June 2023., 2023
Abstract Recent advances in the selective breeding of broilers and layers have made poultry production one of the fastest‐growing industries. In this study, a transcriptome variant calling approach from RNA‐seq data was used to determine population diversity between broilers and layers.
Muhammad Arsalan Iqbal, Frieder Hadlich, Henry Reyer, Michael Oster, Nares Trakooljul, Eduard Murani, Alvaro Perdomo‐Sabogal, Klaus Wimmers, Siriluck Ponsuksili   +8 more
wiley   +1 more source

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +1 more source

Dcf1 induces glioblastoma cells apoptosis by blocking autophagy

Cancer Medicine, Volume 11, Issue 1, Page 207-223, January 2022., 2022
Dcf1 destabilized the structure of the nucleosome via downregulating HistoneH2A.X and the binding to UBA52 but not macroH2A or HistoneH2A.Z, which induced DNA damage and inhibit the recruitment of DNA repair complex. Dcf1 overexpression decreased the mitochondrial DNA copy number, inhibited the mitochondrial biogenesis and induced mitochondrial ...
Guanghong Luo, Ruili Feng, Wengang Li, Yanlu Chen, Yangyang Sun, Junfeng Ma, Yanhong Duo, Tieqiao Wen   +7 more
wiley   +1 more source

Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory

Molecular Brain, 2020
Inositol phosphate metabolism has emerged as one of the key players in synaptic transmission. Previous studies have shown that the deletion of inositol hexakisphosphate kinase 1 (IP6K1), which is responsible for inositol pyrophosphate biosynthesis ...
Min-Gyu Kim, Seungjae Zhang, Hoyong Park, Seung Ju Park, Seyun Kim, ChiHye Chung   +5 more
doaj   +1 more source

A gene network of uterine luminal epithelium organizes mouse blastocyst implantation

Reproductive Medicine and Biology, Volume 21, Issue 1, January/December 2022., 2022
Abstract Purpose The receptive endometrium is critical for blastocyst implantation. In mice, after blastocysts enter the uterine cavities on day 4 of pregnancy (day 1 = vaginal plug), blastocyst attachment is completed within 24 h, accompanied by dynamic interactions between the uterine luminal epithelium and the blastocysts.
Shizu Aikawa, Yasushi Hirota, Yamato Fukui, Chihiro Ishizawa, Rei IIda, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo, Yutaka Osuga   +10 more
wiley   +1 more source

Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia [PDF]

Science Translational Medicine, 2018
IP6K1-mediated polyP production by platelets promotes neutrophil-platelet aggregation and neutrophil accumulation in bacterial pneumonia.
Qingming Hou, Fei Liu, Anutosh Chakraborty, Yonghui Jia, Amit Prasad, Hongbo Yu, Li Zhao, Keqiang Ye, Solomon H. Snyder, Yuanfu Xu, Hongbo R. Luo   +10 more
openaire   +2 more sources

Identification of Differentially Expressed microRNAs Associated with Ischemic Stroke by Integrated Bioinformatics Approaches

International Journal of Genomics, Volume 2022, Issue 1, 2022., 2022
Ischemic stroke (IS) is one of the leading causes of disability and mortality worldwide. This study aims to find the crucial exosomal miRNAs associated with IS by using bioinformatics methods, reveal potential biomarkers for IS, and investigate the association between the identified biomarker and immune cell pattern in the peripheral blood of IS ...
Shengqiang Jiang, Jie Wu, Yan Geng, Yuting Zhang, Yupeng Wang, Jinrong Wu, Chunqu Lu, Guoxuan Luo, Jie Zan, Yong Zhang, Luca Falzone   +10 more
wiley   +1 more source