Results 41 to 50 of about 1,062 (145)
Inositol hexakisphosphate kinase 1 (IP6K1) regulates inositol synthesis in mammalian cells [PDF]
The FASEB Journal, 2016 myo-Inositol, the precursor of all inositol compounds, has pivotal roles in cell metabolism and signaling pathways. Although physiological studies indicate a strong correlation between abnormal intracellular inositol levels and neurological disorders, very little is known about the regulation of inositol synthesis in mammalian cells.
Wenxi, Yu +2 more
openaire +2 more sources
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
Journal of Extracellular Vesicles, Volume 10, Issue 12, October 2021., 2021 Abstract Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double‐edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically harmful in age‐related diseases.
Yujia Yin +4 more
wiley +1 more source
Gastrointestinal Tract Homeostasis: The Role of the Inositol Polyphosphate Multikinase. [PDF]
Cell Mol Gastroenterol Hepatol, 2022 Saiardi A.
europepmc +3 more sources
Analytical Cellular Pathology, Volume 2021, Issue 1, 2021., 2021 The role of long noncoding RNAs‐ (lncRNAs‐) associated competing endogenous RNA (ceRNA) in the field of hepatocellular carcinoma (HCC) biology is well established, but the involvement of lncRNAs competing interactions in the progression of liver cirrhosis to HCC is still unclear.
Yuli Zhang +6 more
wiley +1 more source
Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses
iScience, 2020 Summary: The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), are versatile signaling ...
Seung Ju Park +6 more
doaj +1 more source
Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport [PDF]
Biochemical Journal, 2016 Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP7), are conserved eukaryotic signaling molecules that possess pyrophosphate and monophosphate moieties. Generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine pyrophosphorylation. Here,
Chanduri, Manasa +6 more
openaire +2 more sources
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
Molecules, 2020 In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated
Sandip Mukherjee +2 more
doaj +1 more source
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis [PDF]
Journal of Clinical Investigation, 2016 Enhancing energy expenditure (EE) is an attractive strategy to combat obesity and diabetes. Global deletion of Ip6k1 protects mice from diet-induced obesity (DIO) and insulin resistance, but the tissue-specific mechanism by which IP6K1 regulates body weight is unknown.
Qingzhang, Zhu +7 more
openaire +2 more sources
Protein pyrophosphorylation: moving forward [PDF]
, 2016 Genetic ablation of inositol pyrophosphate synthesis has established the fundamental importance of this class of molecules to the eukaryote cell. These studies, however, must be complemented by cell biology and biochemical approaches to appreciate the ...
Saiardi, A
core +3 more sources
IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution [PDF]
Stem Cells, 2017 Abstract Mesenchymal stem/stromal cells (MSCs) are the predominant source of bone and adipose tissue in adult bone marrow and play a critical role in skeletal homeostasis. Age-induced changes in bone marrow favor adipogenesis over osteogenesis leading to skeletal involution and increased marrow adiposity so pathways that prevent MSC ...
Siddaraju V. Boregowda +5 more
openaire +2 more sources