Results 41 to 50 of about 573 (120)

Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Inositol polyphosphates (IPs) are a group of inositol metabolites that act as secondary messengers for external signalling cues. They play various physiological roles such as insulin release, telomere length maintenance, cell metabolism, and aging ...
Myunghwan Ahn, Seung Eun Park, Jiyeon Choi, Jiahn Choi, Doyoung Choi, Dongju An, Hayoung Jeon, Soowhan Oh, Kiho Lee, Jaehoon Kim, Jaebong Jang, Seyun Kim, Youngjoo Byun   +12 more
doaj   +1 more source

Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases

Molecules, 2020
In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated
Sandip Mukherjee, Jake Haubner, Anutosh Chakraborty   +2 more
doaj   +1 more source

IP6K1 upregulates the formation of processing bodies by promoting proteome remodeling on the mRNA cap [PDF]

, 2020
Abstract Inositol hexakisphosphate kinases (IP6Ks) are ubiquitously expressed small molecule kinases that catalyze the conversion of the inositol phosphate IP6 to 5-IP7. IP6Ks have been reported to influence cellular functions by protein-protein interactions independent of their enzymatic activity. Here, we show that IP6K1 regulates the
Akruti Shah, Rashna Bhandari
openaire   +1 more source

Proteomic Insights Into Susceptibility and Resistance to Chronic-Stress-Induced Depression or Anxiety in the Rat Striatum

Frontiers in Molecular Biosciences, 2021
Chronic stress is a key factor for the onset of anxiety and depression disorders. However, the stress-induced common and unique molecular basis of the two psychiatric disorders is not fully known and still needs to be explored.
Xiao Cai, Chen Yang, Jin Chen, Jin Chen, Weibo Gong, Faping Yi, Wei Liao, Rongzhong Huang, Rongzhong Huang, Liang Xie, Liang Xie, Jian Zhou   +11 more
doaj   +1 more source

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP₇

Biomolecules, 2023
Inositol pyrophosphates (PP-InsPs); are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code.
Soumyadip Sahu, Jacob Gordon, Chunfang Gu, Mack Sobhany, Dorothea Fiedler, Robin E. Stanley, Stephen B. Shears   +6 more
doaj   +1 more source

Integrin‐associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients

The Journal of Physiology, Volume 598, Issue 24, Page 5701-5716, 15 December 2020., 2020
Key points Patients with renal failure undergoing maintenance haemodialysis are associated with insulin resistance and protein metabolism dysfunction. Novel research suggests that disruption to the transmembrane protein linkage between the cytoskeleton and the extracellular matrix in skeletal muscle may contribute to reduced amino acid metabolism and ...
Fulvia Draicchio, Stephan van Vliet, Oana Ancu, Scott A. Paluska, Kenneth R. Wilund, Monika Mickute, Thozhukat Sathyapalan, Derek Renshaw, Peter Watt, Lykke Sylow, Nicholas A. Burd, Richard WA Mackenzie   +11 more
wiley   +1 more source

Resource: A multi‐species multi‐timepoint transcriptome database and webpage for the pineal gland and retina

Journal of Pineal Research, Volume 69, Issue 3, October 2020., 2020
Abstract The website and database https://snengs.nichd.nih.gov provides RNA sequencing data from multi‐species analysis of the pineal glands from zebrafish (Danio rerio), chicken (White Leghorn), rat (Rattus novegicus), mouse (Mus musculus), rhesus macaque (Macaca mulatta), and human (Homo sapiens); in most cases, retinal data are also included along ...
Eric Chang, Cong Fu, Steven L. Coon, Shahar Alon, Marjan Bozinoski, Matthew Breymaier, Diego M. Bustos, Samuel J. Clokie, Yoav Gothilf, Caroline Esnault, P. Michael Iuvone, Christopher E. Mason, Margaret J. Ochocinska, Adi Tovin, Charles Wang, Pinxian Xu, Jinhang Zhu, Ryan Dale, David C. Klein   +18 more
wiley   +1 more source

IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids [PDF]

Journal of Cell Science, 2017
ABSTRACT Inositol hexakisphosphate kinases (IP6Ks) are enzymes that synthesise the inositol pyrophosphate 5-diphosphoinositol pentakisphosphate (5-IP7), which is known to regulate several physiological processes. Deletion of IP6K1, but not other IP6K isoforms, causes sterility in male mice.
Aushaq Bashir Malla, Rashna Bhandari
openaire   +4 more sources

IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution [PDF]

Stem Cells, 2017
Abstract Mesenchymal stem/stromal cells (MSCs) are the predominant source of bone and adipose tissue in adult bone marrow and play a critical role in skeletal homeostasis. Age-induced changes in bone marrow favor adipogenesis over osteogenesis leading to skeletal involution and increased marrow adiposity so pathways that prevent MSC ...
Siddaraju V. Boregowda, Sarbani Ghoshal, Cori N. Booker, Veena Krishnappa, Anutosh Chakraborty, Donald G. Phinney   +5 more
openaire   +2 more sources

Inositol hexakisphosphate kinases 1 and 2 (IP6K1/2) are involved in renal control of phosphate homeostasis

The FASEB Journal, 2021
Phosphate (Pi) is an indispensable component of living organisms. In the body, Pi homeostasis is tightly regulated by four main tissues: intestine, kidney, bone and parathyroid glands. There are multiple complex mechanisms underlying the regulation of serum Pi including hormones and transporters.
Betül Haykir, Adolfo Saiardi, Nati Hernando, Carsten Wagner   +3 more
openaire   +1 more source