Results 41 to 50 of about 737 (136)

Identification of Differentially Expressed microRNAs Associated with Ischemic Stroke by Integrated Bioinformatics Approaches

International Journal of Genomics, Volume 2022, Issue 1, 2022., 2022
Ischemic stroke (IS) is one of the leading causes of disability and mortality worldwide. This study aims to find the crucial exosomal miRNAs associated with IS by using bioinformatics methods, reveal potential biomarkers for IS, and investigate the association between the identified biomarker and immune cell pattern in the peripheral blood of IS ...
Shengqiang Jiang, Jie Wu, Yan Geng, Yuting Zhang, Yupeng Wang, Jinrong Wu, Chunqu Lu, Guoxuan Luo, Jie Zan, Yong Zhang, Luca Falzone   +10 more
wiley   +1 more source

Roles of extracellular vesicles in the aging microenvironment and age‐related diseases

Journal of Extracellular Vesicles, Volume 10, Issue 12, October 2021., 2021
Abstract Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double‐edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically harmful in age‐related diseases.
Yujia Yin, Huihui Chen, Yizhi Wang, Ludi Zhang, Xipeng Wang   +4 more
wiley   +1 more source

Myo-Inositol treatment inhibits motility in triple negative breast cancer via miR-125a-5p/IP6K1 axis

, 2019
Background: Several researches have been performed with the aim of identifying drugs able in blocking PI3K/Akt pathway. We have already demonstrated that myo-Inositol (myo-Ins) treatment can block EMT in breast cancer cells by downregulating PI3K/Akt and inducing changes in cytoskeletal architecture.
Minini Mirko, Proietti Sara, He Xingkang, Senni Alice, Monti Noemi, Fuso Andrea, Cucina Alessandra, Cao Yihai, Bizzarri Mariano   +8 more
openaire   +2 more sources

Comprehensive Analysis of Competing Endogenous RNA Network Focusing on Long Noncoding RNA Involved in Cirrhotic Hepatocellular Carcinoma

Analytical Cellular Pathology, Volume 2021, Issue 1, 2021., 2021
The role of long noncoding RNAs‐ (lncRNAs‐) associated competing endogenous RNA (ceRNA) in the field of hepatocellular carcinoma (HCC) biology is well established, but the involvement of lncRNAs competing interactions in the progression of liver cirrhosis to HCC is still unclear.
Yuli Zhang, Dinggui Chen, Miaomiao Yang, Xianfeng Qian, Chunmei Long, Zhongwei Zheng, Viswanathan Pragasam   +6 more
wiley   +1 more source

Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Inositol polyphosphates (IPs) are a group of inositol metabolites that act as secondary messengers for external signalling cues. They play various physiological roles such as insulin release, telomere length maintenance, cell metabolism, and aging ...
Myunghwan Ahn, Seung Eun Park, Jiyeon Choi, Jiahn Choi, Doyoung Choi, Dongju An, Hayoung Jeon, Soowhan Oh, Kiho Lee, Jaehoon Kim, Jaebong Jang, Seyun Kim, Youngjoo Byun   +12 more
doaj   +1 more source

Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin. [PDF]

Cardiovasc Res
Aims Adiponectin is an adipocyte-derived circulating protein that exerts cardiovascular and metabolic protection. Due to the futile degradation of endogenous adiponectin and the challenges of exogenous administration, regulatory mechanisms of adiponectin
Fu L, Du J, Furkert D, Shipton ML, Liu X, Aguirre T, Chin AC, Riley AM, Potter BVL, Fiedler D, Zhang X, Zhu Y, Fu C.   +12 more
europepmc   +2 more sources

Proteomic Insights Into Susceptibility and Resistance to Chronic-Stress-Induced Depression or Anxiety in the Rat Striatum

Frontiers in Molecular Biosciences, 2021
Chronic stress is a key factor for the onset of anxiety and depression disorders. However, the stress-induced common and unique molecular basis of the two psychiatric disorders is not fully known and still needs to be explored.
Xiao Cai, Chen Yang, Jin Chen, Jin Chen, Weibo Gong, Faping Yi, Wei Liao, Rongzhong Huang, Rongzhong Huang, Liang Xie, Liang Xie, Jian Zhou   +11 more
doaj   +1 more source

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP₇

Biomolecules, 2023
Inositol pyrophosphates (PP-InsPs); are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code.
Soumyadip Sahu, Jacob Gordon, Chunfang Gu, Mack Sobhany, Dorothea Fiedler, Robin E. Stanley, Stephen B. Shears   +6 more
doaj   +1 more source

IP6K1 upregulates the formation of processing bodies by promoting proteome remodeling on the mRNA cap [PDF]

, 2020
Abstract Inositol hexakisphosphate kinases (IP6Ks) are ubiquitously expressed small molecule kinases that catalyze the conversion of the inositol phosphate IP6 to 5-IP7. IP6Ks have been reported to influence cellular functions by protein-protein interactions independent of their enzymatic activity. Here, we show that IP6K1 regulates the
Akruti Shah, Rashna Bhandari
openaire   +1 more source

Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis [PDF]

Journal of Clinical Investigation, 2016
Enhancing energy expenditure (EE) is an attractive strategy to combat obesity and diabetes. Global deletion of Ip6k1 protects mice from diet-induced obesity (DIO) and insulin resistance, but the tissue-specific mechanism by which IP6K1 regulates body weight is unknown.
Qingzhang, Zhu, Sarbani, Ghoshal, Ana, Rodrigues, Su, Gao, Alice, Asterian, Theodore M, Kamenecka, James C, Barrow, Anutosh, Chakraborty   +7 more
openaire   +2 more sources