Results 1 to 10 of about 9,448,134 (130)

Chemoenzymatic Radiosynthesis of a Gluconate Transporter‐Targeted In Vivo Bacterial Sensor From Clinical [18F]FDG

open access: yesAngewandte Chemie International Edition, EarlyView.
An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee   +7 more
wiley   +1 more source

Stage‐Dependent Metabolic Reprogramming Drives a Self‐Organizing Microbial Network During Shanxi Aged Vinegar

open access: yesFood Bioengineering, EarlyView.
Metabolic shifts from growth to stress adaptation in Shanxi aged vinegar fermentation link flavor maturation and microbial cooperation, and Lactobacillus and Acetobacter form a self‐organizing metabolic network through division of labor. ABSTRACT Acetic acid fermentation (AAF) is a vital stage in the production of Shanxi aged vinegar (SAV), during ...
Yanfang Wu   +6 more
wiley   +1 more source

Metabolite Profiles and Antioxidant Activity of Dendrobium catenatum Under Simulated Wild Cultivation

open access: yesFood Safety and Health, EarlyView.
Dendrobium catenatum grown under simulated wild cultivation showed significantly higher flavonoids and stilbenes, leading to enhanced antioxidant activity in both leaves and stems compared to facility‐grown plants. Integrated metabolomics, antioxidant assays, and network pharmacology identified Denbinobin as a key multi‐target antioxidant compound ...
Chuyun Guan   +7 more
wiley   +1 more source

Virtual single‐cell perturbation and genetic causal inference reveal CSF1R‐dependent immunometabolic communication in iron metabolism‐associated osteoarthritis

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Integrative genetic, single‐cell, and perturbation analyses identify CSF1R as a macrophage‐centered immunometabolic signaling hub linking iron dysregulation to osteoarthritis. CSF1R‐driven monocyte–macrophage remodeling may coordinate immune activation, extracellular matrix remodeling, and cartilage degeneration, providing a potential therapeutic ...
Yue Zhou   +6 more
wiley   +1 more source

Recent and Promising Strategies for Robust, Sustainable, and Cost‐Friendly Production of Yogurt With Superior Quality

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Yogurt is one of the most technologically mature fermented dairy products on the market, traditionally prepared using the two lactic acid bacteria (LAB) Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus. Global demand for yogurt continues to rise, driven by consumer interest in healthy, high‐protein diets with as few ...
Shuangqing Zhao   +2 more
wiley   +1 more source

Mechanistic insights into HapC: A key enzyme in prodiginine biosynthesis in Hahella chejuensis

open access: yesThe FEBS Journal, Volume 293, Issue 17, Page 5303-5317, September 2026.
HapC catalyzes prodiginine biosynthesis through coordinated movements of its ATP‐binding, substrate‐binding, and catalytic‐swivel domains. The enzyme shows tolerance toward short‐chain MAP analogs, and docking analyses reveal key residues and structural features underlying its substrate flexibility.
Yueh‐Te Chan   +10 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, Volume 600, Issue 15, Page 2154-2174, August 2026.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Stage‐Specific Metabolic and Proteomic Dynamics Underlying Ripening and Quality Formation in Tropical Evergreen Pomegranate

open access: yeseFood, Volume 7, Issue 4, August 2026.
Integrated multi‐omics reveals that pomegranate ripening between 90 and 130 days drives optimal sugar‐acid balance and pigmentation via coordinated regulation of phenylpropanoid, flavonoid, and carbohydrate metabolism pathways. ABSTRACT Pomegranate fruit development involves coordinated physiological, metabolic, and proteomic changes shaping coloration
Yawen Zhang   +6 more
wiley   +1 more source

Understanding of Molecular Mechanisms and Breeding Strategies for Enhancing Oleic Acid Biosynthesis in Oil Crops

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Oleic acid (C18:1), a monounsaturated fatty acid, is a key determinant of nutritional value and oxidative stability of vegetable oils. Increasing its concentration has therefore become a central objective in oilseed crop improvement. This review summarizes current knowledge on the molecular mechanisms and breeding strategies underlying oleic ...
Muhammad Jawad Umer   +12 more
wiley   +1 more source

Enhanced Rice Yellow Mottle Virus Resistance via CRISPR/Cas9‐Targeted Mutagenesis of the Rice eIF(iso)4G Gene

open access: yesMolecular Plant Pathology, Volume 27, Issue 7, July 2026.
Using CRISPR/Cas9 to edit the susceptibility gene in rice eIF(iso)4G helped to lower the infection of rice yellow mottle virus in mutated lines of the Indica rice cultivar IR2793‐80‐01. ABSTRACT Rice is a staple crop primarily recognised for its high content of carbohydrates and proteins.
Antony Kigaru   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy