Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis
, 2023 Phosphate plays numerous indispensable biochemical roles in all living organisms. Many enzymes act on the phosphorylated form of substrates rather than on the nonphosphorylated form. Usually, the phosphate group does not directly participate in catalysis
Tittmann, Kai +9 more
core +2 more sources
Cytoplasmic Lipid Membrane Biogenesis in Prokaryotes: From Soluble Lipid Building Blocks to a Dynamic and Functional Boundary Layer [PDF]
ChembiochemLipid membranes are fundamental to all prokaryotic life. Besides acting as barrier, by orienting as hydrophobic bilayer, lipids are involved in a wide variety of other cellular processes. As a consequence, prokaryotic membranes are dynamic entities that switch their lipid composition as required; a process that requires tight interplay with the lipid ...
Gan S, Exterkate M.
europepmc +2 more sources
Singular Features of Trypanosomatids' Phosphotransferases Involved in Cell Energy Management [PDF]
, 2011 Trypanosomatids are responsible for economically important veterinary affections and severe human diseases. In Africa,Trypanosoma bruceicauses sleeping sickness or African trypanosomiasis, while in America,Trypanosoma cruziis the etiological agent of ...
Pereira, Claudio Alejandro +7 more
core +1 more source
Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase [PDF]
, 2011 A previously determined crystal structure of the ternary complex of trehalose-6-phosphate synthase identified a putative transition state–like arrangement based on validoxylamine A 6?-O-phosphate and uridine diphosphate in the active site.
Errey, James C. +11 more
core +1 more source
Organic solar cells based on acceptor-functionalized diketopyrrolopyrrole derivatives [PDF]
, 2015 This work was supported by the EPSRC (grants EP/E036244 and EP/I00343X).The synthesis and characterization of three solution processable diketopyrrolopyrrole (DPP) derivatives featuring acceptor units attached to the core by alkyne linker units is ...
Rotello, Vince +6 more
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Electrical rectification from aligned diodesbased on the donor-(π-bridge)-acceptor molecules [PDF]
, 2007 As traditional devices containing silicon transistors begin to approach their physical limits, new systems composed of organic molecules are being considered for molecularscale devices of the future.
Chwialkowska, Anna
core +4 more sources
Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee +7 more
wiley +2 more sources
Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis [PDF]
, 2019 Tuberculosis causes over one million yearly deaths, and drug resistance is rapidly developing. Mycobacterium tuberculosis phosphatidylinositol phosphate synthase (PgsA1) is an integral membrane enzyme involved in biosynthesis of inositol-derived ...
Bennett, Matthew D., +5 more
core +1 more source
Significantly enriched third level enzyme types in essential genes.
, 2013 Significantly enriched third enzyme types of (A) EC 6.1.1: ligases forming aminoacyl-tRNA (B) EC 2.7.7: nucleotidyltransferases (C) EC 2.7.4: phosphotransferases with a phosphate group as acceptor, in essential genes.
Feng Gao (3548) +1 more
core +1 more source
, 1998 The enzymes that phosphorylate nucleosides fall into two groups on the basis of the phosphate donors and the reaction mechanism. One group, the nucleoside kinases, utilizes nucleoside triphosphates as donors in direct displacement reactions; the other ...
Tabucchi A. +13 more
core +1 more source