Combinatorial omics analysis reveals perturbed lysosomal homeostasis in collagen VII-deficient keratinocytes [PDF]
, 2018 The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are ...
Athanasiou, Ioannis +13 more
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The structure and function of human brain hexokinase [PDF]
, 1996 An ATP binding site model for human brain hexokinase was established based on the similarity of the ATP-binding domains among actin, heat shock protein, glycerol kinase and brain hexokinase.
Zeng, Chenbo
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Natural Products Containing ‘Rare’ Organophosphorus Functional Groups [PDF]
, 2019 Phosphorous-containing molecules are essential constituents of all living cells. While the phosphate functional group is very common in small molecule natural products, nucleic acids, and as chemical modification in protein and peptides, phosphorous can ...
Bains, William +2 more
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Function assignment within the haloacid dehalogenase superfamily [PDF]
, 2012 The HaloacidDehalogenase Enzyme Superfamily (HADSF) is a ubiquitous family of enzymes. Presently, more than 45,000 deposited gene sequences encode proteins of the HADSF, and only a fraction of these have defined structure and/or function.
huang, hua
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The Biosynthesis of Capuramycin-type Antibiotics: Identification of the A-102395 Biosynthetic Gene Cluster, Mechanism of Self-Resistence, and Formation of Uridine-5\u27-Carboxamide [PDF]
, 2015 A-500359s, A-503083s, and A-102395 are capuramycin-type nucleoside antibiotics that were discovered using a screen to identify inhibitors of bacterial translocase I, an essential enzyme in peptidoglycan cell wall biosynthesis. Like the parent capuramycin,
Baba, Satoshi +15 more
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Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions [PDF]
, 2005 Phospholipids and sphingolipids play critical roles in signal transduction, intracellular membrane trafficking, and control of cell growth and survival.
SIGAL, Yury J. +2 more
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Pyrimidine nucleoside phosphorylation in developing seeds and germinating seedlings of wheat [PDF]
, 1989 Uridine- and thymidine-phosphorylating enzymes were measured in developing and germinating seeds of Triticum aestivum v. Arthur and T. aestivum v. Lemhi.
Rowe, Martha L.
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COMPARATIVE APPROACHES FOR PLANT GENOMES: UNRAVELING "INTRA" AND "INTER" SPECIES RELATIONSHIPS FROM PRELIMINARY GENE ANNOTATIONS [PDF]
, 2016 Comparative genomics studies the differences and similarities between different species, to transfer biological information from model organisms to newly sequenced genomes, and to understand the evolutionary forces that drive changes in genomic features ...
Ambrosino, Luca
core
Theoretical Studies on Mechanism of Inactivation of Kanamycin A by 4′-O-Nucleotidyltransferase [PDF]
, 2019 This work is focused on mechanistic studies of the transfer of an adenylyl group (Adenoside-5′-monophosfate) from adenosine 5′-triphosphate (ATP) to a OH-4′ hydroxyl group of an antibiotic.
Agatha Bastida +2 more
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Arylboronic Acids With Strong Fluorescence Intensity Changes Upon Sugar Binding [PDF]
, 2011 Boronic acids play an important role in the design and synthesis of chemosensors for carbohydrates due to their ability to reversibly bind with diol-containing compounds.
Laughlin, Sarah R
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