Results 21 to 30 of about 3,964 (89)

Hydrologic History Regulates Microbial Biofilm Diversity and Ecosystem Function

Environmental Microbiology, Volume 28, Issue 4, April 2026.
Hydrologic history regulates microbial biofilm diversity and ecosystem function. Historical flooding, but not drought, led to broad changes in composition and functional genes. ABSTRACT Aquatic biofilms are an understudied component of northern peatlands and are expected to play a more prominent role in ecosystem processes in areas where aquatic ...
Allison R. Rober, Leah C. Reese, Shawn P. Brown, Katherine D. McMahon, Stilianos Louca, Jillian Cieslik, Evan S. Kane, Merritt R. Turetsky, Kevin H. Wyatt   +8 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

NIR Light‐Driven Photocatalytic Antibacterial Hydrogels for Synergistic MRSA Biofilm Eradication and Wound Regeneration

Advanced Science, Volume 13, Issue 14, 9 March 2026.
The nanohybrid hydrogel (Fe‐BOS@C/H Gel) is composed of Fe‐Bi2O2‐XS (Fe‐BOS) photocatalysts and CS‐ADH/OHA (C/H) hydrogel. Fe‐BOS photocatalysts achieve near‐infrared (NIR) light‐driven antibacterial photocatalytic/mild photothermal therapy (APCT/MPTT), effectively eliminating methicillin‐resistant Staphylococcus aureus (MRSA) biofilms. The degradation
Dong Mo, Yujia Wei, Meng Pan, Wen Chen, Yun Yang, Kang Li, Xicheng Li, Jianan Li, Qingya Liu, Hanzi Deng, Mei Zhu, Zhenpeng Zhang, Zhaolin Xiao, Zhiyong Qian   +13 more
wiley   +1 more source

In and out of the mitochondrial intermembrane space

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Mitochondria are essential organelles constituted by two membranes, the outer (OMM) and inner mitochondrial membrane (IMM), and two aqueous compartments, the intermembrane space (IMS) and the matrix. Although mitochondria contain their own genome, which encodes for 13 proteins in humans (8 in budding yeast), the vast majority (99%) of ...
Fara van der Schans, Kostas Tokatlidis, Daniela G. Vitali   +2 more
wiley   +1 more source

Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Allosteric modulation is a promising strategy for selective kinase inhibition, yet structural insights into allosteric pockets remain limited across the human kinome. In this work, we present comprehensive characterization of a type III allosteric pocket in the insulin receptor kinase (IRK), integrating structural, conformational, and ...
Jyoti Verma, Harish Vashisth
wiley   +1 more source

AHP4 attenuates cytokinin signalling in the phloem companion cells to control root growth under osmotic stress

The Plant Journal, Volume 125, Issue 2, January 2026.
SUMMARY Cytokinins regulate diverse aspects of plant development. They are perceived by membrane‐localised receptors that transmit a signal to nuclear‐localised response regulators via the Histidine Phosphotransfer proteins (HPts). These HPts can be divided into two classes: authentic HPts (AHPs), which positively regulate cytokinin signalling, and ...
Elina Chrysanthou, Shannon Ward, Kartika Sari, John Vaughan‐Hirsch, Aditi N. Borkar, Rahul Bhosale, Anthony Bishopp   +6 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, Volume 599, Issue 23, Page 3417-3443, December 2025.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Structures of two LarA‐like nickel‐pincer nucleotide cofactor‐utilizing enzymes with a single catalytic histidine residue

Protein Science, Volume 34, Issue 12, December 2025.
Abstract The nickel‐pincer nucleotide (NPN) cofactor catalyzes the racemization/epimerization of α‐hydroxy acids in enzymes of the LarA family. The established proton‐coupled hydride transfer mechanism requires two catalytic histidine residues that alternately act as general acids and general bases. Notably, however, a fraction of LarA homologs (LarAHs)
Santhosh Gatreddi, Sundharraman Subramanian, Dexin Sui, Tianqi Wang, Julian Urdiain‐Arraiza, Benoît Desguin, Robert P. Hausinger, Kristin N. Parent, Jian Hu   +8 more
wiley   +1 more source

Unveiling the Potential of Lentilactobacillus hilgardii in Malolactic Fermentation: Comparative Genomics and Fermentation Dynamics

Microbial Biotechnology, Volume 18, Issue 12, December 2025.
This study explores the metabolic potential of Lentilactobacillus hilgardii for malolactic fermentation in winemaking. Genomic and in silico analyses, combined with experimental validation, reveal its resilience at low temperatures and unique enzymatic traits. Comparative insights with Oenococcus oeni highlight L.
Giacomo Mantegazza, Nicola Mangieri, Elnaz Vojoudi Yazdi, Pasquale Russo, Diego Mora, Giorgio Gargari   +5 more
wiley   +1 more source

A commensal protozoan exacerbates acetaminophen-induced liver injury by producing free sphingosine. [PDF]

Gut Microbes
Yan X, Shen Y, Sun Q, Zhu X, Chen Q, Liao L, Zhou Y, Cheng W, Shi Z, Liu Z, Wei Y, Liu X, Wang Y, Kou Y.   +13 more
europepmc   +1 more source