Results 51 to 60 of about 737 (136)

Inositol hexakisphosphate kinases 1 and 2 (IP6K1/2) are involved in renal control of phosphate homeostasis

The FASEB Journal, 2021
Phosphate (Pi) is an indispensable component of living organisms. In the body, Pi homeostasis is tightly regulated by four main tissues: intestine, kidney, bone and parathyroid glands. There are multiple complex mechanisms underlying the regulation of serum Pi including hormones and transporters.
Betül Haykir, Adolfo Saiardi, Nati Hernando, Carsten Wagner   +3 more
openaire   +1 more source

Integrin‐associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients

The Journal of Physiology, Volume 598, Issue 24, Page 5701-5716, 15 December 2020., 2020
Key points Patients with renal failure undergoing maintenance haemodialysis are associated with insulin resistance and protein metabolism dysfunction. Novel research suggests that disruption to the transmembrane protein linkage between the cytoskeleton and the extracellular matrix in skeletal muscle may contribute to reduced amino acid metabolism and ...
Fulvia Draicchio, Stephan van Vliet, Oana Ancu, Scott A. Paluska, Kenneth R. Wilund, Monika Mickute, Thozhukat Sathyapalan, Derek Renshaw, Peter Watt, Lykke Sylow, Nicholas A. Burd, Richard WA Mackenzie   +11 more
wiley   +1 more source

Resource: A multi‐species multi‐timepoint transcriptome database and webpage for the pineal gland and retina

Journal of Pineal Research, Volume 69, Issue 3, October 2020., 2020
Abstract The website and database https://snengs.nichd.nih.gov provides RNA sequencing data from multi‐species analysis of the pineal glands from zebrafish (Danio rerio), chicken (White Leghorn), rat (Rattus novegicus), mouse (Mus musculus), rhesus macaque (Macaca mulatta), and human (Homo sapiens); in most cases, retinal data are also included along ...
Eric Chang, Cong Fu, Steven L. Coon, Shahar Alon, Marjan Bozinoski, Matthew Breymaier, Diego M. Bustos, Samuel J. Clokie, Yoav Gothilf, Caroline Esnault, P. Michael Iuvone, Christopher E. Mason, Margaret J. Ochocinska, Adi Tovin, Charles Wang, Pinxian Xu, Jinhang Zhu, Ryan Dale, David C. Klein   +18 more
wiley   +1 more source

Monitoring Phytate Hydrolysis Using Serial Blood Sampling and Feather Myo-Inositol Levels in Broilers

Frontiers in Physiology, 2020
Phytate forms insoluble precipitates with various cations that are recalcitrant to digestion in poultry. Dietary supplementation with exogenous phytase has been shown to improve phytate solubility and digestibility and, in turn, improve animal growth ...
Elizabeth Greene, Barbara Mallmann, Jonathan W. Wilson, Aaron J. Cowieson, Sami Dridi   +4 more
doaj   +1 more source

The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle

Frontiers in Nutrition, 2019
Sarcopenia is defined as the combined loss of skeletal muscle strength, function, and/or mass with aging. This degenerative loss of muscle mass is associated with poor quality of life and early mortality humans.
Richie D. Barclay, Nicholas A. Burd, Christopher Tyler, Neale A. Tillin, Richard W. Mackenzie   +4 more
doaj   +1 more source

IP6K1 rewires LKB1 signaling to mediate hyperglycemic endothelial senescence

Diabetes
<p dir="ltr">Diabetes is a major risk factor for cardiovascular disease, but the molecular mechanisms underlying diabetic vasculopathy have been elusive. Here we report that inositol hexakisphosphate kinase 1 (IP6K1) mediates hyperglycemia-induced endothelial senescence by rewiring the liver kinase B1 (LKB1) signaling from activating the ...
Changchang Xing, Linhui Shi, Limei Zhu, Tim Aguirre, Ji Qi, Yuanyuan Chen, Yue Liu, Alfred C. Chin, Hong Zhu, Dorothea Fiedler, Alex F. Chen, Chenglai Fu   +11 more
openaire   +2 more sources

Predicting MicroRNA Target Genes and Identifying Hub Genes in IIA Stage Colon Cancer Patients Using Bioinformatics Analysis

BioMed Research International, Volume 2019, Issue 1, 2019., 2019
Background. Colon cancer is a heterogeneous disease, differing in clinical symptoms, epigenetics, and prognosis for each individual patient. Identifying the core genes is important for early diagnoses and it provides a more precise method for treating colon cancer. Materials and Methods.
Zhiyong Dong, Wei Lin, Stacy A. Kujawa, Shike Wu, Cunchuan Wang, Giandomenico Roviello   +5 more
wiley   +1 more source

The inositol pyrophosphates are essential for the development of mammals [PDF]

, 2022
Inositol polyphosphates, generated from a second messenger IP3 by a series of kinases, are a family of endogenous metabolites conserved across evolution. Inositol polyphosphates participate in diverse physiological activities, including insulin secretion,
He, Sining
core   +3 more sources

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

Inositols in Insulin Signaling and Glucose Metabolism

International Journal of Endocrinology, Volume 2018, Issue 1, 2018., 2018
In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of inositol, inhibiting, among others, its intestinal absorption.
Arturo Bevilacqua, Mariano Bizzarri, Marco Bugliani   +2 more
wiley   +1 more source