Results 71 to 80 of about 573 (120)

Inositol hexakinase phosphate 1 (IP6K1) is implicated in the insulin response to protein ingestion in older adults

Abstract Age-related muscle mass is driven by a reduction in insulin sensitivity partly mediated by reduced amino acid and anabolic signalling kinetics. Insulin activates Akt-mTORC1 signalling in skeletal muscle with inositol hexokinase phosphate 1 (IP6K1) shown to inhibit this signalling pathway in pre-diabetic ...
Richie D. Barclay, Diana E. Motei, Oana Ancu, Christopher J. Tyler, Neale A. Tillin, Volker Behrends, Nicholas A. Burd, Nicholas M. Hurren, Richard W.A. Mackenzie   +8 more
openaire   +1 more source

IP6K1 Gene [PDF]

, 2020
openaire   +1 more source

IP6K1 wt Allele [PDF]

, 2020
openaire   +1 more source

Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors. [PDF]

ACS Med Chem Lett, 2023
Heitmann T, Liao G, de León P, Ernst G, Buchler I, Wei H, Shlevkov E, Brown D, Fitzek M, Collier M, Smith DM, Barrow JC.   +11 more
europepmc   +1 more source

Inhibition of IP6K1 Suppresses NPC Formation via Platelet Short-Chain Polyphosphate Polymers in Necrotizing Enterocolitis

Abstract Necrotizing enterocolitis (NEC) is a life-threatening intestinal inflammatory disease in preterm infants. Inositol hexakisphosphate kinase 1 (IP6K1) regulates platelet polyphosphate (polyP) homeostasis, yet their roles in NEC remain unclear.
Kai Gao, Muyang Zhu, Qianyang Liu, Yue Ma, Hongmei Xu, Chunbao Guo   +5 more
openaire   +1 more source

Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling. [PDF]

Biomed Pharmacother, 2023
Qi J, Cheng W, Gao Z, Chen Y, Shipton ML, Furkert D, Chin AC, Riley AM, Fiedler D, Potter BVL, Fu C.   +10 more
europepmc   +1 more source

The inositol pyrophosphate 5-InsP₇ regulates mitochondrial polyphosphate synthesis and bioenergetic function. [PDF]

J Biol Chem
Ladke JS, Khan A, Singh A, Jessen HJ, Kolthur-Seetharam U, Jaiswal M, Bhandari R.   +6 more
europepmc   +1 more source

β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner. [PDF]

Proc Natl Acad Sci U S A, 2023
Eisenbeis VB, Qiu D, Gorka O, Strotmann L, Liu G, Prucker I, Su XB, Wilson MSC, Ritter K, Loenarz C, Groß O, Saiardi A, Jessen HJ.   +12 more
europepmc   +1 more source

Role of Inositol Hexakisphosphate Kinases in Vascular Smooth Muscle Cell Calcification. [PDF]

Int J Mol Sci
Bahiraii S, Jannat I, Plösser S, Razazian M, Voelkl J, Alesutan I.   +5 more
europepmc   +1 more source

Structural Rationalization of IPMK Inhibitor Potency. [PDF]

J Med Chem
Wang H, Shears SB, Blind RD.
europepmc   +1 more source