Results 71 to 80 of about 737 (136)

Requirement of Inositol Pyrophosphates for Full Exocytotic Capacity in Pancreatic β Cells

, 2007
Inositol pyrophosphates are recognized components of cellular processes that regulate vesicle trafficking, telomere length, and apoptosis. We observed that pancreatic β cells maintain high basal concentrations of the pyrophosphate diphosphoinositol ...
Barker, Christopher J., Leibiger, B,, Yang, Shao-Nian, Saiardi, Adolfo, Fiume, R, Falck, JR, Falck, John R., Illies, Christopher, Fiume, Roberta, Berggren, Per-Olof, Barma, DK, Leibiger, Barbara, Juhl, Kirstine, Gromada, Jesper, Saiardi, A, Illies, C,, Gromada, J, Yu, Jia, Yu, J,, Yang, S-N, Juhl, K, Barma, Deb K.   +21 more
core   +2 more sources

Inhibition of Inositol hexakisphosphate Kinase 1 (IP6K1) Does Not Increase Akt or mTOR Activity in vitro .

The FASEB Journal, 2018
Background Inositol hexakisphosphate Kinase 1 (IP6K1) has been identified as a key signalling enzyme that inhibits Akt activity in hepatic cell lines and diabetic rodent models (Chakraborty et al., 2010; 2012; Goshal et al., 2016).
Richie Barclay, Richard Mackenzie
openaire   +1 more source

Inhibition of IP6K1 Suppresses NPC Formation via Platelet Short-Chain Polyphosphate Polymers in Necrotizing Enterocolitis

Inflammation Research
Abstract Necrotizing enterocolitis (NEC) is a life-threatening intestinal inflammatory disease in preterm infants. Inositol hexakisphosphate kinase 1 (IP6K1) regulates platelet polyphosphate (polyP) homeostasis, yet their roles in NEC remain unclear.
Kai Gao, Muyang Zhu, Qianyang Liu, Yue Ma, Hongmei Xu, Chunbao Guo   +5 more
openaire   +1 more source

High‐intensity Interval Exercise decreases IP6K1 Muscle Content & Improves Insulin Sensitivity (S _I ^2* ) in Pre‐diabetic Individuals

The FASEB Journal, 2018
Insulin resistance in skeletal muscle contributes to whole body hyperglycaemia in pre‐diabetic and type 2 diabetic individuals. Insulin‐dependent glucose uptake in skeletal muscle requires the upregulation of the Akt‐AS160 signalling cascade (Bruss et al., 2005; Mackenzie & Elliott, 2014).
Jane Naufahu, Bradley Elliott, Oana Ancu, Fulvia Draicchio, Anatoliy Markiv, Nicholas M. Hurren, David Howard, Peter Watt, Richard W.A. Mackenzie   +8 more
openaire   +1 more source

Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain

, 2010
SummaryThe inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate), formed by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates diverse cellular activities. We now report that IP7 is a physiologic inhibitor of Akt, a serine/
Mezey, Esteban, Saleh, Masoumeh, Krishna R. Juluri, Dailey, Megan J., Solomon H. Snyder, Snowman, Adele M., James J. Potter, Timothy H. Moran, David Maag, Adele M. Snowman, Michael A. Koldobskiy, Micah Maxwell, Alex S. Huang, Bello, Nicholas T., Juluri, Krishna R., Snyder, Solomon H., Anutosh Chakraborty, Potter, James J., Maxwell, Micah, Moran, Timothy H., Chakraborty, Anutosh, Huang, Alex S., Seyun Kim, Masoumeh Saleh, Esteban Mezey, Koldobskiy, Michael A., Maag, David, Kim, Seyun, Nicholas T. Bello, Megan J. Dailey   +29 more
core   +1 more source

Mammalian mitochondrial polyphosphate is regulated by the 5-InsP ₇ synthase IP6K1

Abstract Inorganic polyphosphate (polyP) is a linear polymer of varying length composed of phosphate residues linked by phosphoanhydride bonds. PolyP remains poorly understood in mammals due to its low abundance and lack of information on its synthesis and regulation. Using synthetic polyP 8
Jayashree S. Ladke, Azmi Khan, Anshit Singh, Jyoti Singh, Nicole Steck, Henning J. Jessen, Ullas Kolthur-Seetharam, Manish Jaiswal, Rashna Bhandari   +8 more
openaire   +1 more source

이노시톨 파이로인산 대사의 뇌 기능과 행동에서의 역할 규명

, 2020
학위논문(박사) - 한국과학기술원 : 생명과학과, 2020.8,[vii, 94 p. :]Inositol pyrophosphates, which are elucidated to versatile signaling metabolites in many biological events such as growth and metabolism.
Kim, Min-Gyu
core  

이노시톨 폴리포스페이트 인산화효소에 의한 골수성 세포 기능 및 신호전달 조절 규명

, 2022
학위논문(박사) - 한국과학기술원 : 생명과학과, 2022.2,[viii, 84 p. :]Inositol polyphosphate multikinase (IPMK) and inositol hexakisphosphate 1 (IP6K1) are pleiotropic enzymes essential for the biosynthesis of inositol polyphosphate.
Lee, Haein
core  

Inositol hexakinase phosphate 1 (IP6K1) is implicated in the insulin response to protein ingestion in older adults

Abstract Age-related muscle mass is driven by a reduction in insulin sensitivity partly mediated by reduced amino acid and anabolic signalling kinetics. Insulin activates Akt-mTORC1 signalling in skeletal muscle with inositol hexokinase phosphate 1 (IP6K1) shown to inhibit this signalling pathway in pre-diabetic ...
Richie D. Barclay, Diana E. Motei, Oana Ancu, Christopher J. Tyler, Neale A. Tillin, Volker Behrends, Nicholas A. Burd, Nicholas M. Hurren, Richard W.A. Mackenzie   +8 more
openaire   +1 more source

The catalytic activity of inositol pyrophosphate synthesis pathway kinases regulates IFNβ response.

, 2014
(A, B) Ectopic expression of inositol pyrophosphate-synthesis-pathway kinases enhanced RIG-I mediated IFNβ-promoter driven luciferase reporter activity. HEK293 cells transfected with the indicated concentrations of empty vector, or expression plasmids of
Richa Tyagi (528103), Pradeep D. Uchil (86592), Sajith Nair (528099), Andrew M. Riley (286874), Aleksandar D. Kostic (528100), Pradeep Bist (528101), Jeremy D. Weaver (528102), Ramnik J. Xavier (153776), Manoj N. Krishnan (207688), Niyas Kudukkil Pulloor (528098), Adolfo García-Sastre (51848), Rongtuan Lin (159368), Stephen B. Shears (528105), John D. York (528104), Solomon H. Snyder (68303), Barry V. L. Potter (286876)   +15 more
core   +1 more source