Results 71 to 80 of about 1,062 (145)

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast [PDF]

, 2023
Although many prokaryotes have glycolysis alternatives, it\u27s considered as the only energy-generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid-glycolysis yeast.
Chen, Yu, Chen, Yun, Dong, Genlai, Jessen, Henning J., Ji, Xu, Jiang, Junfeng, Larsson, Christer, Li, Chaokun, Li, Lingyun, Liu, Zihe, Luo, Hao, Nielsen, Jens B, Pereira, Rui, Qin, Ning, Qiu, Danye, Shi, Shuobo, Tan, Tianwei, Wan, Xiaozhen, Xia, Jianye, Yin, Shile, Zhang, Yiming, Zhang, Yueping   +21 more
core   +1 more source

Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells [PDF]

, 2013
Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC.
A Cusimano, A Cusimano, A Cusimano, Antonella Cusimano, Antonina Azzolina, B Pyrzynska, B Yu, B Zhao, BC Lin, C Cai, CA Hall, CM Schmidt, D Bachvarov, D Foderà, D Levy, Dimcho Bachvarov, DM French, E Bertini, E Lapi, EN Gurzov, ET Sawey, G Montalto, Giuseppe Montalto, H Hao, H Koga, H Nakabayashi, HB El-Serag, HK Ho, James A. McCubrey, KS Yee, L Giannitrapani, M Cervello, M Cervello, M Cervello, M Cervello, M Cervello, M Cervello, M Cervello, M Nakamura, MA Kern, Manlio Vinciguerra, Melchiorre Cervello, MU Latasa, MZ Xu, N Inohara, N Lampiasi, N Lampiasi, N Ohoka, Nadia Lampiasi, PL Mercier, S Basu, S Miura, SS Cao, T Muramatsu, W Poh, X Zhang, Y Wang   +56 more
core   +3 more sources

The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export [PDF]

Journal of Biological Chemistry, 2019
Phosphate's central role in most biochemical reactions in a living organism requires carefully maintained homeostasis. Although phosphate homeostasis in mammals has long been studied at the organismal level, the intracellular mechanisms controlling phosphate metabolism are not well-understood.
Miranda S. Wilson, Henning J. Jessen, Adolfo Saiardi   +2 more
openaire   +4 more sources

Predicting MicroRNA Target Genes and Identifying Hub Genes in IIA Stage Colon Cancer Patients Using Bioinformatics Analysis

BioMed Research International, Volume 2019, Issue 1, 2019., 2019
Background. Colon cancer is a heterogeneous disease, differing in clinical symptoms, epigenetics, and prognosis for each individual patient. Identifying the core genes is important for early diagnoses and it provides a more precise method for treating colon cancer. Materials and Methods.
Zhiyong Dong, Wei Lin, Stacy A. Kujawa, Shike Wu, Cunchuan Wang, Giandomenico Roviello   +5 more
wiley   +1 more source

IP6K1 rewires LKB1 signaling to mediate hyperglycemic endothelial senescence

Diabetes
<p dir="ltr">Diabetes is a major risk factor for cardiovascular disease, but the molecular mechanisms underlying diabetic vasculopathy have been elusive. Here we report that inositol hexakisphosphate kinase 1 (IP6K1) mediates hyperglycemia-induced endothelial senescence by rewiring the liver kinase B1 (LKB1) signaling from activating the ...
Changchang Xing, Linhui Shi, Limei Zhu, Tim Aguirre, Ji Qi, Yuanyuan Chen, Yue Liu, Alfred C. Chin, Hong Zhu, Dorothea Fiedler, Alex F. Chen, Chenglai Fu   +11 more
openaire   +2 more sources

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Lingguizhugan Decoction Protects against High‐Fat‐Diet‐Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion

International Journal of Genomics, Volume 2017, Issue 1, 2017., 2017
Background. Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of liver transplantation. Lingguizhugan decoction (LGZG), a classical Chinese herbal formula, has beneficial effects on NAFLD animal models. Our study examined the impact of LGZG on hepatic global transcriptome of high‐fat‐diet‐induced NAFLD rats. Methods.
Lili Yang, Weili Lin, Colleen A. Nugent, Shijun Hao, Haiyan Song, Tao Liu, Peiyong Zheng, Peijian He   +7 more
wiley   +1 more source

Molecular mechanisms of perilipin protein function in lipid droplet metabolism

FEBS Letters, Volume 598, Issue 10, Page 1170-1198, May 2024.
Lipid droplets (LDs) are important for the storage of energy and lipid components. The perilipin family in mammals includes five proteins (PLIN1 to PLIN5), all of which are abundant on the surface of LDs in different tissues and play a role in LD stability and degradation by lipases.
Elena Griseti, Abdoul Akim Bello, Eric Bieth, Bayane Sabbagh, Jason S. Iacovoni, Joëlle Bigay, Henrik Laurell, Alenka Čopič   +7 more
wiley   +1 more source

The enzymes of human diphosphoinositol polyphosphate metabolism

The FEBS Journal, Volume 281, Issue 1, Page 14-33, January 2014., 2014
This review covers the three classes of enzymes involved in the metabolism of diphosphoinositol polyphosphates – inositol hexakisphosphate kinases (IP6K), inositol hexakisphosphate and diphosphoinositol‐pentakisphosphate kinases (PPIP5K), and diphosphoinositol polyphosphate phosphohydrolases (DIPP).
Mark P. Thomas, Barry V. L. Potter
wiley   +1 more source