Pharmacological Inhibition of Inositol Hexakisphosphate Kinase 1 Protects Mice against Obesity-Induced Bone Loss [PDF]
Biology, 2022 Obesity and type II diabetes mellitus (T2DM) are prominent risk factors for secondary osteoporosis due to the negative impacts of hyperglycemia and excessive body fat on bone metabolism.
Siddaraju V. Boregowda +6 more
doaj +4 more sources
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity. [PDF]
PLoS ONE, 2017 Inositol pyrophosphates have been implicated in a wide range of cellular processes. Inositol hexakisphosphate kinase 1 catalyzes the pyrophosphorylation of inositol hexakisphosphate into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate which is important
Michael Wormald +4 more
doaj +5 more sources
Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory [PDF]
Molecular Brain, 2020 Inositol phosphate metabolism has emerged as one of the key players in synaptic transmission. Previous studies have shown that the deletion of inositol hexakisphosphate kinase 1 (IP6K1), which is responsible for inositol pyrophosphate biosynthesis ...
Min-Gyu Kim +5 more
doaj +5 more sources
Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1 [PDF]
Scientific Reports, 2018 Inositol hexakisphosphate kinase-1 (IP6K1) is required for male fertility, but the underlying mechanisms have been elusive. Here, we report that IP6K1 is required for multiple aspects of male germ cell development.
Chenglai Fu +7 more
doaj +5 more sources
Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance Inositol hexakisphosphate kinase 1 (IP6K1) regulates numerous physiological functions. We describe a role of IP6K1 in neural development, because its deletion results in defects in neuronal migration and brain malformation. IP6K1 physiologically interacts with α-actinin and localizes to focal adhesions.
Fu C +7 more
europepmc +6 more sources
Inositols in Insulin Signaling and Glucose Metabolism [PDF]
International Journal of Endocrinology, 2018 In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of
Arturo Bevilacqua, Mariano Bizzarri
doaj +2 more sources
Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis. [PDF]
Int J Biochem Cell Biol, 2016 Lipolysis leads to the breakdown of stored triglycerides (TAG) to release free fatty acids (FFA) and glycerol which is utilized by energy expenditure pathways to generate energy. Therefore, a decrease in lipolysis augments fat accumulation in adipocytes which promotes weight gain.
Ghoshal S +3 more
europepmc +4 more sources
Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells. [PDF]
J Biol Chem, 2016 myo-Inositol, the precursor of all inositol compounds, has pivotal roles in cell metabolism and signaling pathways. Although physiological studies indicate a strong correlation between abnormal intracellular inositol levels and neurological disorders, very little is known about the regulation of inositol synthesis in mammalian cells.
Yu W, Ye C, Greenberg ML.
europepmc +4 more sources
Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport. [PDF]
Biochem J, 2016 Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP7), are conserved eukaryotic signaling molecules that possess pyrophosphate and monophosphate moieties. Generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine pyrophosphorylation. Here,
Chanduri M +6 more
europepmc +4 more sources
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.
Cell Signal, 2018 Diphosphoinositol pentakisphosphate (IP7) is critical for the exocytotic capacity of the pancreatic β-cell, but its regulation by the primary instigator of β-cell exocytosis, glucose, is unknown. The high Km for ATP of the IP7-generating enzymes, the inositol hexakisphosphate kinases (IP6K1 and 2) suggests that these enzymes might serve as metabolic ...
Rajasekaran SS +16 more
europepmc +4 more sources