Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity. [PDF]
PLoS ONE, 2017 Inositol pyrophosphates have been implicated in a wide range of cellular processes. Inositol hexakisphosphate kinase 1 catalyzes the pyrophosphorylation of inositol hexakisphosphate into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate which is important
Michael Wormald +4 more
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Pharmacological Inhibition of Inositol Hexakisphosphate Kinase 1 Protects Mice against Obesity-Induced Bone Loss [PDF]
Biology, 2022 Obesity and type II diabetes mellitus (T2DM) are prominent risk factors for secondary osteoporosis due to the negative impacts of hyperglycemia and excessive body fat on bone metabolism.
Siddaraju V. Boregowda +6 more
doaj +6 more sources
Inositol hexakisphosphate kinase 1 is implicated in the insulin response to protein ingestion in older adults [PDF]
Scientific ReportsAge-related muscle mass is driven by a reduction in insulin sensitivity partly mediated by reduced amino acid and anabolic signalling kinetics. Insulin activates Akt-mTORC1 signalling in skeletal muscle, with inositol hexakisphosphate kinase 1 (IP6K1 ...
Richie D. Barclay +8 more
doaj +6 more sources
Inositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 Is Required for Homologous Recombination Repair [PDF]
Journal of Biological Chemistry, 2013 Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP(7)), are water-soluble inositol phosphates that contain high energy diphosphate moieties on the inositol ring. Inositol hexakisphosphate kinase 1 (IP6K1) participates in inositol pyrophosphate synthesis, converting inositol hexakisphosphate (IP(6)) to IP(7).
Sagar Sengupta +2 more
exaly +6 more sources
Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory [PDF]
Molecular Brain, 2020 Inositol phosphate metabolism has emerged as one of the key players in synaptic transmission. Previous studies have shown that the deletion of inositol hexakisphosphate kinase 1 (IP6K1), which is responsible for inositol pyrophosphate biosynthesis ...
Min-Gyu Kim +5 more
doaj +5 more sources
Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1 [PDF]
Scientific Reports, 2018 Inositol hexakisphosphate kinase-1 (IP6K1) is required for male fertility, but the underlying mechanisms have been elusive. Here, we report that IP6K1 is required for multiple aspects of male germ cell development.
Chenglai Fu +7 more
doaj +5 more sources
Insights Into the Roles of Inositol Hexakisphosphate Kinase 1 (IP6K1) in Mammalian Cellular Processes [PDF]
Journal of Biological ChemistryInositol phosphates and their metabolites play a significant role in several biochemical pathways, gene expression regulation, and phosphate homeostasis. Among the different inositol phosphates, inositol hexakisphosphate (IP6) is a substrate of inositol hexakisphosphate kinases (IP6Ks), which phosphorylate one or more of the IP6 phosphate groups ...
Miriam L Greenberg
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Neuronal Migration Is Mediated by Inositol Hexakisphosphate Kinase 1 via α-Actinin and Focal Adhesion Kinase [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Inositol hexakisphosphate kinase 1 (IP6K1) regulates numerous physiological functions. We describe a role of IP6K1 in neural development, because its deletion results in defects in neuronal migration and brain malformation. IP6K1 physiologically interacts with α-actinin and localizes to focal adhesions.
Alfred C Chin, Weiwei Cheng, Tomas Rojas
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Ingestion of Lean Meat Elevates Muscle Inositol Hexakisphosphate Kinase 1 Protein Content Independent of a Distinct Post-Prandial Circulating Proteome in Young Adults With Obesity [PDF]
Metabolism: Clinical and Experimental, 2020 We have recently shown that a novel signalling kinase, inositol hexakisphosphate kinase 1 (IP6K1), is implicated in whole-body insulin resistance via its inhibitory action on Akt. Insulin and insulin like growth factor 1 (IGF-1) share many intracellular processes with both known to play a key role in glucose and protein metabolism in skeletal muscle.We
Nicholas A Burd +2 more
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Exercise suppresses IP6K3 to modulate BCAA metabolism and ferroptosis in MASLD [PDF]
Cellular & Molecular Biology LettersBackground Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to branched-chain amino acid (BCAA) dysmetabolism and ferroptosis, and exercise is considered protective, yet the underlying mechanisms remain unclear.
Zi-Chen Li +13 more
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