Results 21 to 30 of about 107,826,167 (138)
Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death. [PDF]
Proc Natl Acad Sci U S A, 2014 Significance Attachment of the small protein ubiquitin to other proteins, a process called “ubiquitylation,” triggers protein degradation. The Cullin and signalosome protein families cooperatively mediate this process, but how they are regulated has been obscure.
Rao F +9 more
europepmc +4 more sources
Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies. [PDF]
Adv Sci (Weinh)Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Saiardi A +5 more
europepmc +2 more sources
Inositol pyrophosphate kinases in health and disease. [PDF]
FEBS LettIn mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Xing C +6 more
europepmc +2 more sources
Animal Cells and Systems, 2022 A family of inositol hexakisphosphate kinases (IP6Ks) catalyzes the production of inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate) which is known to modulate various biological events such as cell growth. While targeting IP6K1 in various
Haein Lee +4 more
doaj +1 more source
Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates. [PDF]
FEBS LettInositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Rolfes RJ.
europepmc +2 more sources
A Role for Rat Inositol Polyphosphate Kinases rIPK2 and rIPK1 in Inositol Pentakisphosphate and Inositol Hexakisphosphate Production in Rat-1 Cells [PDF]
Journal of Biological Chemistry, 2005 Over 30 inositol polyphosphates are known to exist in mammalian cells; however, the majority of them have uncharacterized functions. In this study we investigated the molecular basis of synthesis of highly phosphorylated inositol polyphosphates (such as inositol tetrakisphosphate, inositol pentakisphosphate (IP5), and inositol hexakisphosphate (IP6 ...
Makoto, Fujii, John D, York
openaire +2 more sources
PLoS Pathogens, 2021 Gag polymerization with viral RNA at the plasma membrane initiates HIV-1 assembly. Assembly processes are inefficient in vitro but are stimulated by inositol (1,3,4,5,6) pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) metabolites.
Gregory A Sowd, Christopher Aiken
doaj +1 more source
Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways [PDF]
Molecular Psychiatry, 2013 Glycogen synthase kinase 3 (GSK3), a prominent enzyme in carbohydrate metabolism, also has a major role in brain function. It is physiologically regulated by the kinase Akt, which phosphorylates GSK3 to inhibit catalytic activity. Inositol hexakisphosphate-1 (IP6K1) generates the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP7), which ...
A, Chakraborty +4 more
openaire +2 more sources
The maternal ITPK1 gene polymorphism is associated with neural tube defects in a high-risk Chinese population. [PDF]
PLoS ONE, 2014 BACKGROUND: Epidemiological surveys and animal studies have revealed that inositol metabolism is associated with NTDs, but the mechanisms are not clear. Inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) is a pivotal regulatory enzyme in inositol metabolic ...
Zhen Guan +9 more
doaj +1 more source