Results 41 to 50 of about 107,826,167 (138)

Overexpression of a Gene Involved in Phytic Acid Biosynthesis Substantially Increases Phytic Acid and Total Phosphorus in Rice Seeds

Plants, 2015
The manipulation of seed phosphorus is important for seedling growth and environmental P sustainability in agriculture. The mechanism of regulating P content in seed, however, is poorly understood.
Yusuke Tagashira, Tomoe Shimizu, Masanobu Miyamoto, Sho Nishida, Kaoru T. Yoshida   +4 more
doaj   +1 more source

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Molecular Metabolism, 2016
Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration.
Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty   +10 more
doaj   +1 more source

The structure of myo-inositol-hexakisphosphate (InsP6).

, 2018
The structure of myo-inositol-hexakisphosphate (InsP6).
Akira Odani (492835), Kazuma Ogawa (492825), Miho Aoki (492828), Sumi Kadono (5052140)   +3 more
core   +1 more source

The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle

Frontiers in Nutrition, 2019
Sarcopenia is defined as the combined loss of skeletal muscle strength, function, and/or mass with aging. This degenerative loss of muscle mass is associated with poor quality of life and early mortality humans.
Richie D. Barclay, Nicholas A. Burd, Christopher Tyler, Neale A. Tillin, Richard W. Mackenzie   +4 more
doaj   +1 more source

p53-mediated apoptosis requires inositol hexakisphosphate kinase-2

, 2010
Inositol pyrophosphates have been implicated in numerous biological processes. Inositol hexakisphosphate kinase-2 (IP6K2), which generates the inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP7), influences apoptotic cell death.
Seyun Kim, Adele M. Snowman, Michael A. Koldobskiy, Anutosh Chakraborty, Krishna R. Juluri, Shira Heletz, J. Kent Werner, Solomon H. Snyder, M. Scott Vandiver   +8 more
core   +1 more source

The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment

Bioscience Reports, 2013
We obtained detailed kinetic characteristics–stoichiometry, reaction rates, substrate affinities and equilibrium conditions–of human PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). This enzyme synthesizes ‘high-energy’
Jeremy D. Weaver, Huanchen Wang, Stephen B. Shears   +2 more
doaj   +1 more source

Structural and functional insights into rhodopsin‐like and secretin‐like GPCR–arrestin interactions and regulation

The FEBS Journal, EarlyView.
Distinct GPCR phosphorylation barcodes and arrestin conformational states direct arrestin‐mediated signaling and trafficking. The graphical abstract depicts the structural diversity of GPCR–arrestin complexes by overlaying representative core‐engaged and tail‐engaged conformations.
Varsha Gupta, Annette G. Beck‐Sickinger   +1 more
wiley   +1 more source

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate [PDF]

, 2015
Bruton's tyrosine kinase (Btk), a Tec-family tyrosine kinase, is essential for B-cell function. We present crystallographic and biochemical analyses of Btk, which together reveal molecular details of its autoinhibition and activation.
Zorn, Julie A, Harrison, Stephen, Stephen C Harrison, John Kuriyan, Laura M Nocka, Vogan, Erik M, Julie A Zorn, Harrison, Stephen C, Erik M Vogan, Rosen, Connor E, Wang, Qi, Kuriyan, John, Qi Wang, Connor E Rosen, Nocka, Laura M   +14 more
core   +1 more source

QTL Mapping of Several Seed Quality Traits in the DH Population NPZ06 × NPZ09 (Brassica napus L.) for Marker‐Assisted Selection

Plant Breeding, EarlyView.
ABSTRACT Enhancing nutritional quality of oilseed rape requires deeper insight into the genetic control of seed quality traits. This study analysed the effect of varying soil phosphorus (P) levels on seed quality traits in the hybrid cultivar Architect. NIRS and laboratory methods were used to quantify total seed P and phytic acid (IP6) content.
Jasmin Vettel, Markus Rodehutscord, Christian Möllers   +2 more
wiley   +1 more source

Inositol hexakisphosphate stimulates non-Ca2+-mediated and primes Ca2+-mediated exocytosis of insulin by activation of protein kinase C [PDF]

, 1997
d - myo -inositol 1,2,3,4,5,6-hexakisphosphate (InsP 6 ), formed via complex pathways of inositol phosphate metabolism, composes the main bulk of inositol polyphosphates in the cell.
Berggren, PO, Zaitsev, SV, Zaitsev, Sergei V., Efanov, Alexandre M., Berggren, Per-Olof, Efanov, AM   +5 more
core   +1 more source