Results 61 to 70 of about 107,826,167 (138)
Pathogenic Mechanisms of V. vulnificus and Its Role in the Development of Sepsis
MicrobiologyOpen, Volume 15, Issue 3, June 2026.Sorafenib attenuates urethral scar formation by inhibiting β‐catenin signaling in fibroblasts, which downregulates the SLC7A11/GPX4 antioxidant axis and triggers ferroptosis. This β‐catenin–ferroptosis coupling effectively suppresses fibrogenesis, highlighting sorafenib as a promising drug‐repurposing candidate for urethral stricture.
Zhongying Yu +7 more
wiley +1 more source
Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers +16 more
wiley +1 more source
Addiction Biology, Volume 31, Issue 1, January 2026.Rats treated with the domain‐selective BET inhibitor RVX‐208 during a 2‐week forced abstinence period exhibited a reduction in cocaine‐seeking behaviour but not sucrose seeking or open field behaviour. This treatment effect was associated with proteomic changes in pathways relevant to dopaminergic and glutamatergic signalling in the nucleus accumbens ...
Tyler J. Sacko +3 more
wiley +1 more source
Safety evaluation of pectin‐rich extract derived from Coffea arabica as food additive
EFSA Journal, Volume 24, Issue 1, January 2026.Abstract The EFSA Panel on Food Additives and Flavourings (FAF Panel) provides a scientific opinion on the safety assessment of the proposed use of pectin rich extract derived from Coffea arabica L. as a food additive. The proposed food additive consists of 70%–85% dietary fibres (of which the major part is pectin), 4%–6.5% proteins and substances of ...
EFSA Panel on Food Additives and Flavourings (FAF) +27 more
wiley +1 more source
, 1994 We have partially purified an enzyme activity that phosphorylates inositol 1,3,4-trisphosphate from porcine brain, rat liver and bovine testis by FPLC chromatography on Q-Sepharose anion-exchange resin and Heparin-agarose.
Kirk, Christopher J. +2 more
core +1 more source
Biotechnology and Bioengineering, Volume 122, Issue 12, Page 3486-3495, December 2025.Plouviez et al. give a perspective on the terminology used for describing the mechanisms of polyphosphate accumulation in microalgae and yeast. Their differentiation of mechanisms is based on environmental P availability, polyP chemistry, genetics, or cellular function as described in recent literature.
Maxence Plouviez +7 more
wiley +1 more source
PharmaceuticalsRecent research has uncovered a promising approach to addressing the growing global health concern of obesity and related disorders. The inhibition of inositol hexakisphosphate kinase 1 (IP6K1) has emerged as a potential therapeutic strategy.
Ismail Mondal +4 more
doaj +1 more source
Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes
Advanced Science, Volume 12, Issue 39, October 20, 2025.This study demonstrates that SLC16A10 plays a crucial role in psoriasis pathogenesis through arachidonic acid metabolism regulation in keratinocytes. Using multi‐omics analysis and experimental validation, researchers identify SLC16A10 as both a diagnostic biomarker and therapeutic target.
Jingyuan Yang +17 more
wiley +1 more source
Strategies Toward Inhibition of Inositol Hexakisphosphate Kinase [PDF]
Inositol is a unique biological small molecule as a cyclohexane ring with stereochemically defined hydroxyl groups on all six carbons of the ring.
Heitmann, Tyler Eric
core +2 more sources