Results 61 to 70 of about 3,089 (138)
High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity in glucose intolerant individuals [PDF]
, 2017 Context Insulin resistance in skeletal muscle contributes to whole body hyperglycaemia and the secondary complications associated with type 2 diabetes.
Dunning-Foreman, P. +15 more
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The FASEB Journal, 2018 Background Inositol hexakisphosphate Kinase 1 (IP6K1) has been identified as a key signalling enzyme that inhibits Akt activity in hepatic cell lines and diabetic rodent models (Chakraborty et al., 2010; 2012; Goshal et al., 2016).
Richie Barclay, Richard Mackenzie
openaire +1 more source
Analysis of Dictyostelium discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis. [PDF]
, 2014 The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Chubb, JR +5 more
core
A tale of two inositol trisphosphates. [PDF]
, 2016 Between spring 1982 and autumn 1984 the physiological role of Ins(1,4,5)P3 as a calcium-mobilizing second messenger was first suggested and then experimentally established.
core +2 more sources
IP6K2 mutations as a novel mechanism of resistance to oncolytic virus therapy
Journal of Translational MedicineBackground Oncolytic virus therapy (OVT) represents a promising frontier in cancer treatment. Despite its efficacy in clinical trials, variability in patient response, particularly resistance development, highlights the need for tailored therapeutic ...
Zhijian Huang +9 more
doaj +1 more source
Metabolic engineering of micronutrients in crop plants [PDF]
, 2016 Micronutrient deficiency is a widespread phenomenon, most prevalent in developing countries. Being causally linked to the occurrence of a range of diseases, it affects billions of people worldwide. Enhancing the content of micronutrients in crop products
Blancquaert, Dieter +3 more
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Simple synthesis of 32P-labelled inositol hexakisphosphates for study of phosphate transformations [PDF]
, 2017 Background and aims In many soils inositol hexakisphosphate in its various forms is as abundant as inorganic phosphate. The organismal and geochemical processes that exchange phosphate between inositol hexakisphosphate and other pools of soil phosphate ...
Brearley, CA +5 more
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Has Inositol Played Any Role in the Origin of Life? [PDF]
, 2017 Phosphorus, as phosphate, plays a paramount role in biology. Since phosphate transfer reactions are an integral part of contemporary life, phosphate may have been incorporated into the initial molecules at the very beginning.
Saiardi, A
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Molecular targets of developmental exposure to bisphenol A in diabesity: a focus on endoderm-derived organs [PDF]
, 2016 Several studies associate foetal human exposure to bisphenol A (BPA) to metabolic/endocrine diseases, mainly diabesity. They describe the role of BPA in the disruption of pancreatic beta cell, adipocyte and hepatocyte functions. Indeed, the complexity of
Almeida, P. +7 more
core +1 more source
, 2020 Additional file 1:Figure S1. The anxiety level in IP6K1-KO mice did not show difference compared with WT mice. (WT n = 7; KO n = 7; two-way ANOVA; main effect of genotype, F(1,24) = 7.898Xe-10, P > 0.9999, effect of position, F(1,24) = 72.34, P < 0.0001; Bonferroni posttest, ns: not significant).
Min-Gyu Kim +5 more
openaire +1 more source