Results 71 to 80 of about 3,089 (138)

Mechanisms and regulation of the polyphosphate/factor XII-driven contact system in thrombosis and hemostasis [PDF]

, 2016
Blood coagulation leading to fibrin formation is essential to prevent loss of blood (hemostasis), but can also contribute to occlusion of vessels (thrombosis).
Labberton, Linda
core   +1 more source

Shaping the Future of Obesity Treatment: In Silico Multi-Modeling of IP6K1 Inhibitors for Obesity and Metabolic Dysfunction

Pharmaceuticals
Recent research has uncovered a promising approach to addressing the growing global health concern of obesity and related disorders. The inhibition of inositol hexakisphosphate kinase 1 (IP6K1) has emerged as a potential therapeutic strategy.
Ismail Mondal, Amit Kumar Halder, Nirupam Pattanayak, Sudip Kumar Mandal, Maria Natalia D. S. Cordeiro   +4 more
doaj   +1 more source

SRSF1-dependent nuclear export of C9ORF72 repeat-transcripts: targeting toxic gain-of-functions induced by protein sequestration as a selective therapeutic strategy for neuroprotection [PDF]

, 2018
Microsatellite repeat expansions cause several incurable and lethal neurodegenerative disorders including ataxias, myotonic dystrophy, Huntington's disease and C9ORF72-linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD ...
Azzouz, M., Castelli, L.M., Ferraiuolo, L., Hautbergue, G.M., Lin, Y.H., Ning, K.E., Sanchez-Martinez, A., Shaw, P.J., Whitworth, A.   +8 more
core   +1 more source

Diet shapes the ability of human intestinal microbiota to degrade phytate - in vitro studies [PDF]

, 2016
Aims: Investigation of intestinal bacterial groups involved in phytate degradation and the impact of diets with different phytate contents on phytase activity.
Haros, Monika, Honke, J., Markiewicz, L. H., Swiatecka, D., Wróblewska, B.   +4 more
core   +1 more source

Phytase: application in food industry [PDF]

, 2010
Phytates have been considered as a threat in human diet due to its antinutrients behaviour which known as strong chelators of divalent minerals such as Ca²+, Mg²+, Zn²+ and Fe²+.
Abd. Manap, Mohd. Yazid, Meor Hussin, Anis Shobirin, Mustafa, Shuhaimi, Suhairin, Afinah   +3 more
core  

Additional file 2 of Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory

, 2020
Additional file 2. Materials and Methods.
Min-Gyu Kim, Seungjae Zhang, Hoyong Park, Park, Seung Ju, Kim, Seyun, ChiHye Chung   +5 more
openaire   +1 more source

Inositol, neural tube closure and the prevention of neural tube defects [PDF]

, 2016
Susceptibility to neural tube defects (NTDs), such as anencephaly and spina bifida is influenced by genetic and environmental factors including maternal nutrition.
Copp, AJ, Greene, ND, Leung, KY
core   +1 more source

Анализ структурных и качественных особенностей депонирования фитина в зрелых семенах льна масличного [PDF]

, 2015
Рассмотрены вопросы запасания фитина в зрелых семенах льна масличного – диапазон накопления, влияние погодно-климатических условий сезона выращивания, морфология и размер фитиновых глобоидов алейроновых зерен.
Вакула, С.И., Леонтьев, В.Н., Лугин, В.Г., Титок, В.В.   +3 more
core   +2 more sources

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion. [PDF]

, 2014
Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement of ...
Andres Obregón‐Henao, Angeleen Fleming, Beate Kampmann, Benard EL, Catherine Klapholz, David C Rubinsztein, Diane J Ordway, Joseph Burgon, Karen Brown, Karen E Anderson, Katherine M Henry, Krisztina Hegyi, Lucy Hepburn, Marcela Henao Tamayo, Mark Schiebler, Maurizio Renna, Phillip T Hawkins, Randall Basaraba, Robert R Kay, Rodrigo Andres Floto, Sandra M Newton, Sarah Coulter, Stephen A Renshaw   +22 more
core   +3 more sources

Phenotypic Screening of Drought-Tolerant Lines for Brown Planthopper, Blast and Phytic Acid Content Assay of Rice (Oryza sativa L.) [PDF]

, 2017
Advanced drought tolerant lines were analysed for blast disease, brown planthopper (BPH), and phytic acid content. Thirsty lines of BC2F4 derived from OMCS2000/ IR75499-73-1 were used to screen for BPH and blast resistance.
Ha, P. T. (Pham), Lang, N. T. (Nguyen), Rayee, R. (Ramin), Tam, D. M. (Dang), Vang, P. K. (PhamThi)   +4 more
core   +1 more source