Results 71 to 80 of about 107,826,167 (138)

Human plasma inositol hexakisphosphate (InsP ₆ ) phosphatase identified as the Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1). [PDF]

MicroPubl Biol
International audienceInositol hexakisphosphate (InsP6), also known as phytic acid, is a potent chelator of bivalent cations. Intracellular InsP6 molecules are associated with magnesium.
Fedeli V, Wang J, Cantagrel V, Saiardi A.   +3 more
europepmc   +2 more sources

Age‐Dependent Histone Deacetylase 3 Regulation by βA3/A1‐Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age‐Related Macular Degeneration

Aging Cell, Volume 24, Issue 9, September 2025.
βA3/A1‐crystallin regulates HDAC3 activity and epigenetic processes in the RPE. (A) The illustration demonstrates that βA3/A1‐crystallin plays a crucial role in maintaining IPMK protein expression, which in turn activates HDAC3. (B) When βA3/A1‐crystallin is absent (Cryba1 KO ), IPMK protein expression decreases, resulting in the deactivation of HDAC3.
Sujan Chatterjee, Sayan Ghosh, Zachary Sin, Vishnu Suresh Babu, Loretta Viera Preval, Emily Davis, Nguyen Tran, Sridhar Bammidi, Pooja Gautam, Stacey Hose, Yuri Sergeev, Miguel Flores‐Bellver, Kevin Ritter, Henning J. Jessen, Issam Al Diri, Debasish Sinha, Prasun Guha   +16 more
wiley   +1 more source

Inositol hexakisphosphate increases L‐type Ca2+ channel activity by stimulation of adenylyl cyclase

, 2001
Inositol hexakisphosphate (InsP6) is a most abundant inositol polyphosphate that changes simultaneously with inositol 1,4,5‐trisphosphate in depolarized neurons. However, the role of InsP6 in neuronal signaling is unknown.
Berggren, PO, Larsson, OLOF, Hofmann, F, Yang, SHAO-NIAN, Yang, SN, Ju, Jia, Berggren, PER-OLOF, Mayr, GEORG W., Hofmann, FRED, Yu, J,, Mayr, GW, YU, JIA, Larsson, O,, GEORG W. MAYR, SHAO-NIAN YANG, JIA YU, PER-OLOF BERGGREN, OLOF LARSSON, FRED HOFMANN   +18 more
core   +1 more source

A PDK1-dependent regulation of PLCγ1 activation is essential for cancer cell migration and invasion [PDF]

, 2011
PhDPhospholipase Cγ1 (PLCγ1) is highly expressed in several tumours such as breast carcinomas and has been found overexpressed in metastases compared to primary tumour in breast cancer patients, indicating that PLCγ1 may be important in tumourigenesis ...
Raimondi, Claudio
core   +2 more sources

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, Volume 15, Issue 7, Page 1113-1123, July 2025.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

Inositol hexakisphosphate stimulates 45Ca2+ uptake in anterior pituitary cells in culture.

, 1990
Inositol hexakisphosphate (InsP6) is thought to act as an intracellular signal molecule in the central nervous system. We report that InsP6 stimulates 45Ca2+ uptake in cultured anterior pituitary cells. This effect is concentration-dependent, is mimicked
NICOLETTI, Ferdinando, M. A. Sortino, P. L. Canonico, CANONICO, PL, NICOLETTI, F, SORTINO, Maria Angela   +5 more
core   +1 more source

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

Diabetes, Metabolic Syndrome and Obesity, 2014
Richard WA Mackenzie, Bradley T Elliott Department of Human and Health Sciences, Facility of Science and Technology, University of Westminster, London, UK Abstract: Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin ...
Mackenzie RWA, Elliott BT
doaj  

Inositol hexakisphosphate promotes dynamin I- mediated endocytosis

, 2002
Membrane homeostasis is maintained by exocytosis and endocytosis. The molecular mechanisms regulating the interplay between these two processes are not clear.
Olsen, Hervør L., Leibiger, Ingo B., Efanov, Alexander M., Gromada, Jesper, Bokvist, Krister, Zwiller, Jean, Zaitsev, Sergei V., Høy, Marianne, Bertorello, Alejandro M., Berggren, Per-Olof, Leibiger, Barbara   +10 more
core   +1 more source

The Inositol- 1,4,5=Trisphosphate System Is Involved in Rapid Effects of Aldosterone in Human Mononuclear Leukocytes [PDF]

, 1993
There is increasing evidence for rapid steroid action on electrolyte transport in human mononuclear leukocytes (HML). In HML, aldosterone stimulates the Na+/H+ antiporter within a few minutes. Because a variety of hormones and growth factors activate the
Wehling, Martin, Theisen, Karl, Eisen, Christoph, Aktas, Janet, Christ, Michael, M. Christ   +5 more
core   +1 more source

The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export [PDF]

, 2019
Phosphate's central role in most biochemical reactions in a living organism requires carefully maintained phosphate homeostasis. Although phosphate homeostasis in mammals has long been studied at the organismal level, the intracellular mechanisms ...
Jessen, HJ, Saiardi, A, Wilson, MS
core   +3 more sources