Results 51 to 60 of about 107,826,167 (138)

Protein kinase CK2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner

, 2021
Protein kinase CK2 is a ubiquitous protein kinase that can phosphorylate various proteins involved in central cellular processes, such as signal transduction, cell division, and proliferation.
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core   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3569-3592, October 2026.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2

, 2011
The inositol pyrophosphate, diphosphoinositol pentakisphosphate, regulates p53 and protein kinase Akt signaling, and its aberrant increase in cells has been implicated in apoptosis and insulin resistance.
Adele M. Snowman, Michael A. Koldobskiy, Anutosh Chakraborty, Krishna R. Juluri, J. Kent Werner, Joseph Pietropaoli, Solomon H. Snyder, Asif K. Mustafa   +7 more
core   +1 more source

Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability

Molecular Brain
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degradation of Na+/K+
Hongfu Jin, Aili Liu, Alfred C. Chin, Chenglai Fu, Hui Shen, Weiwei Cheng   +5 more
doaj   +1 more source

Additional file 1 of Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory

, 2020
Additional file 1:Figure S1. The anxiety level in IP6K1-KO mice did not show difference compared with WT mice. (WT n = 7; KO n = 7; two-way ANOVA; main effect of genotype, F(1,24) = 7.898Xe-10, P > 0.9999, effect of position, F(1,24) = 72.34, P < 0.0001; Bonferroni posttest, ns: not significant).
Kim, Min-Gyu, Zhang, Seungjae, Park, Hoyong, Park, Seung Ju, Kim, Seyun, Chung, ChiHye   +5 more
openaire   +1 more source

Protective Effect of Phytic Acid in Cardiovascular Diseases: A Systematic Review

ChemFoodChem, Volume 2, Issue 3, September 2026.
ABSTRACT Cardiovascular diseases (CVDs) are a cluster of ailments that impact the heart and blood vessels and are a primary public health problem of mortality on a global scale. Phytic acid, a dietary constituent frequently present in foods like seeds, has been linked to many pharmacological attributes, including anti‐cancer, antioxidant, anti ...
Marta M. S. de Freitas Almeida, Éverton A. Pereira, Patricia Severino, Cristina Blanco‐Llamero, Sandra L. Santos, Luciana N. Andrade, Ricardo G. Amaral, Eliana B. Souto   +7 more
wiley   +1 more source

Inhibition of Inositol hexakisphosphate Kinase 1 (IP6K1) Does Not Increase Akt or mTOR Activity in vitro .

The FASEB Journal, 2018
Background Inositol hexakisphosphate Kinase 1 (IP6K1) has been identified as a key signalling enzyme that inhibits Akt activity in hepatic cell lines and diabetic rodent models (Chakraborty et al., 2010; 2012; Goshal et al., 2016).
Richie Barclay, Richard Mackenzie
openaire   +1 more source

IP6K2 mutations as a novel mechanism of resistance to oncolytic virus therapy

Journal of Translational Medicine
Background Oncolytic virus therapy (OVT) represents a promising frontier in cancer treatment. Despite its efficacy in clinical trials, variability in patient response, particularly resistance development, highlights the need for tailored therapeutic ...
Zhijian Huang, Xiangqian Zhao, Zirong Jiang, Xiaoting Qiu, Xinhao Sun, Dawei Wang, Hucheng Zhang, Qi Chen, Ruirong Tan, Yangkun Shen   +9 more
doaj   +1 more source

Advances in Cold‐Plasma Technology for Legume Seeds: Mechanisms, Nutritional Quality Improvement, Food Safety and Sustainable Agriculture

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Cold plasma (CP), a nonthermal ionised gas rich in reactive oxygen and nitrogen species (RONS), has emerged as a sustainable technology for enhancing legume production and quality. This review summarises current advances in CP applications in legumes, focusing on seed germination, seedling vigour, nutrient enhancement, antinutrient reduction ...
Jannatul Ferdous, Joyairia Tabassum, Md. Hassan Bin Nabi, Abid Hassan Arnab, Wahidu Zzaman, Iftekhar Ahmad   +5 more
wiley   +1 more source

Molecular insights and translational opportunities to enhance heat tolerance in rice

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana, Chanderkant Chaudhary, Rajat Pruthi, Mansi Sharma, Bhupinderjeet Singh, Ravi Kiran Reddy Kondi, Mallesham Bulle, Prasanta K. Subudhi   +7 more
wiley   +1 more source