Results 31 to 40 of about 107,826,167 (138)

Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis. [PDF]

, 2009
Inositol pyrophosphates are a recently characterized cell signalling molecules responsible for the pyrophosphorylation of protein substrates. Though likely involved in a wide range of cellular functions, the study of inositol pyrophosphates has suffered ...
Szijgyarto Zsolt, Losito Oriana, Saiardi, A, Losito, O, Adam Cain Resnick, Resnick, AC, Oriana Losito, Resnick Adam Cain, Szijgyarto, Z, Adolfo Saiardi, Zsolt Szijgyarto, Saiardi Adolfo   +11 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues. [PDF]

FEBS Lett
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Seaton-Terry A, Cutright AJ, Loi MNC, Martin J, Gilligan JW, Kubina JN, Arambula MJ, Palmu ST, Zhou D, Blind RD.   +9 more
europepmc   +2 more sources

Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses

iScience, 2020
Summary: The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), are versatile signaling ...
Seung Ju Park, Hoyong Park, Min-Gyu Kim, Seungjae Zhang, Seung Eun Park, Seyun Kim, ChiHye Chung   +6 more
doaj   +1 more source

Inositol hexakisphosphate kinases 1 and 2 (IP6K1/2) are involved in renal control of phosphate homeostasis

The FASEB Journal, 2021
Phosphate (Pi) is an indispensable component of living organisms. In the body, Pi homeostasis is tightly regulated by four main tissues: intestine, kidney, bone and parathyroid glands. There are multiple complex mechanisms underlying the regulation of serum Pi including hormones and transporters.
Betül Haykir, Adolfo Saiardi, Nati Hernando, Carsten Wagner   +3 more
openaire   +1 more source

Effect of Inositol Hexakisphosphate Kinase 2 on Transforming Growth Factor β-activated Kinase 1 and NF-κB Activation [PDF]

Journal of Biological Chemistry, 2007
We previously showed that inositol hexakisphosphate kinase 2 (IHPK2) functions as a growth-suppressive and apoptosis-enhancing kinase during cell stress. Overexpression of IHPK2 sensitized ovarian carcinoma cell lines to the growth-suppressive and apoptotic effects of interferon beta (IFN-beta), IFN-alpha2, and gamma-irradiation. Expression of a kinase-
Bei H, Morrison, Joseph A, Bauer, Joseph A, Lupica, Zhuo, Tang, Heidi, Szugye, Joseph A, DiDonato, Daniel J, Lindner   +6 more
openaire   +2 more sources

A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase [PDF]

, 2018
Inositol pentakisphosphate 2-kinase catalyzes the phosphorylation of the axial 2-OH of myo-inositol 1,3,4,5,6-pentakisphosphate for de novo synthesis of myo-inositol hexakisphosphate.
Riley, Andrew M, Hayley Whitfield (5770313), Kendall Baker (5770319), Gilmartin, Megan, Andrew M. Riley (286874), Hemmings, Andrew M, H. Y. Godage (5770322), Godage, Himali Y, Andrew M. Hemmings (2345116), Baker, Kendall, Brearley, Charles A, Whitfield, Hayley, Potter, Barry, Barry V. L. Potter (286876), Charles A. Brearley (5770325), Megan Gilmartin (5770316), Potter, Barry VL, Godage, Himali   +17 more
core   +3 more sources

Inositols in Insulin Signaling and Glucose Metabolism

International Journal of Endocrinology, 2018
In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of
Arturo Bevilacqua, Mariano Bizzarri
doaj   +1 more source

Monitoring Phytate Hydrolysis Using Serial Blood Sampling and Feather Myo-Inositol Levels in Broilers

Frontiers in Physiology, 2020
Phytate forms insoluble precipitates with various cations that are recalcitrant to digestion in poultry. Dietary supplementation with exogenous phytase has been shown to improve phytate solubility and digestibility and, in turn, improve animal growth ...
Elizabeth Greene, Barbara Mallmann, Jonathan W. Wilson, Aaron J. Cowieson, Sami Dridi   +4 more
doaj   +1 more source

Inositol hexakisphosphate primes syndapin I/PACSIN 1 activation in endocytosis [PDF]

, 2022
Endocytosis is controlled by a well-orchestrated molecular machinery, where the individual players as well as their precise interactions are not fully understood.
Zhao, Kaixuan, Berggren, Per-Olof, Shi, Yue, Yang, Guang, Li, Yuxin, Kessels, Michael M., Yang, Shao-Nian, Kessels, Michael M, Qualmann, Britta, Yu, Lina, Yu, Jia, Yu, L, Shi, Y,, Qualmann, B, Berggren, P-O, Kessels, MM, Yu, J,, Yang, S-N, Li, Y, Zhao, K,, Yang, G, Jia Yu, Yue Shi, Lina Yu, Michael M. Kessels, Shao-Nian Yang, Per-Olof Berggren, Guang Yang, Britta Qualmann, Kaixuan Zhao, Yuxin Li   +30 more
core   +1 more source

Inositol Hexakisphosphate Primes Syndapin I/PACSIN 1 Activation In Endocytosis

, 2021
Endocytosis is controlled by a well-orchestrated molecular machinery, where the individual players as well as their precise interactions are not fully understood.
Yu, L, Qualmann, B, Berggren, P-O, Yu, J, Yang, S-N, Li, Y, Zhao, K, Yang, G, Shi, Y, Kessels, MM   +9 more
core   +1 more source