Results 31 to 40 of about 3,089 (138)

Inositol hexakisphosphate kinases 1 and 2 (IP6K1/2) are involved in renal control of phosphate homeostasis

The FASEB Journal, 2021
Phosphate (Pi) is an indispensable component of living organisms. In the body, Pi homeostasis is tightly regulated by four main tissues: intestine, kidney, bone and parathyroid glands. There are multiple complex mechanisms underlying the regulation of serum Pi including hormones and transporters.
Betül Haykir, Adolfo Saiardi, Nati Hernando, Carsten Wagner   +3 more
openaire   +1 more source

Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasis [PDF]

, 2018
Emerging studies have implicated a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to ...
Alcazar-Roman, Alexova, Auesukaree, Aung, Azevedo, Azevedo, Bari, Berridge, Boer, Bosch, Brearley, Brearley, Brearley, Brearley, Chamberlain, Chiou, Chiou, Cho, Choi, Clough, Curtis, Desai, Duff, Franco-Zorrilla, Gonzalez, Hammond, Hanke, Ho, Holford, Huang, Huang, Irvine, Kanehara, Karimi, Kim, Kuo, Kusano, Laha, Lee, Lee, Lee, Lemtiri-Chlieh, Lemtiri-Chlieh, Lin, Lin, Lin, Liu, Liu, Liu, Lonetti, Martin, Mosblech, Mulugu, Munnik, Munnik, Munnik, Murphy, Müller, Nagy, Norbis, Pant, Perera, Perera, Perera, Phillippy, Pradet, Puga, Raboy, Raboy, Rao, Rouached, Saiardi, Saiardi, Saiardi, Schell, Schneider, Secco, Secco, Shears, Stenzel, Stephens, Stephens, Stevenson-Paulik, Stevenson-Paulik, Sweetman, Szijgyarto, Torabinejad, Vajanaphanich, Voglmaier, Wang, Whiteford, Wild, Williams, Wilson, Wreggett, Wu, Wu, Wundenberg, Xiong, Xu, Xu, Yang, Yang, York, Zonia   +104 more
core   +2 more sources

Effect of Inositol Hexakisphosphate Kinase 2 on Transforming Growth Factor β-activated Kinase 1 and NF-κB Activation [PDF]

Journal of Biological Chemistry, 2007
We previously showed that inositol hexakisphosphate kinase 2 (IHPK2) functions as a growth-suppressive and apoptosis-enhancing kinase during cell stress. Overexpression of IHPK2 sensitized ovarian carcinoma cell lines to the growth-suppressive and apoptotic effects of interferon beta (IFN-beta), IFN-alpha2, and gamma-irradiation. Expression of a kinase-
Bei H, Morrison, Joseph A, Bauer, Joseph A, Lupica, Zhuo, Tang, Heidi, Szugye, Joseph A, DiDonato, Daniel J, Lindner   +6 more
openaire   +2 more sources

The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function [PDF]

, 2017
Inositol 1,3,4,5,6-pentakisphosphate 2-kinases (IP5 2-Ks) comprise a family of enzymes in charge of synthesizing inositol hexakisphosphate (IP6) in eukaryotic cells.
Afonine, Alcázar-Roman, Angulo, Barker, Baños-Sanz, Berridge, Boularan, Brehm, Brehm, Byrum, Caddick, Chakraborty, Cheek, Cowtan, DeLano, Emsley, Evans, Finn, Franco-Echevarria, González, González, Gosein, Gosein, Gosein, Gouet, Gouy, Holm, Holmes, Irvine, Juanhuix, Kabsch, Laskowski, Li, Macbeth, McCoy, Murshudov, Onnebo, Ouyang, Panjikar, Phillippy, Phillippy, Qian, Saiardi, Scherer, Shears, Shears, Stephens, Sweetman, Terwilliger, Terwilliger, Vagin, Verbsky, Verbsky, Wang, Wang, Winn   +55 more
core   +1 more source

Primate lentiviruses require Inositol hexakisphosphate (IP6) or inositol pentakisphosphate (IP5) for the production of viral particles.

PLoS Pathogens, 2020
Inositol hexakisphosphate (IP6) potently stimulates HIV-1 particle assembly in vitro and infectious particle production in vivo. However, knockout cells lacking inositol-pentakisphosphate 2-kinase (IPPK-KO), the enzyme that produces IP6 by ...
Clifton L Ricana, Terri D Lyddon, Robert A Dick, Marc C Johnson   +3 more
doaj   +1 more source

Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease [PDF]

, 2016
Maintenance of electric potential and synaptic transmission are energetically demanding tasks that neuronal metabolism must continually satisfy. Inability to fulfil these energy requirements leads to the development of neurodegenerative disorders ...
Bruni, AC, Crocco, P, Maletta, R, Passarino, G, Rose, G, Saiardi, A, Wilson, MS   +6 more
core   +1 more source

Protein pyrophosphorylation: moving forward [PDF]

, 2016
Genetic ablation of inositol pyrophosphate synthesis has established the fundamental importance of this class of molecules to the eukaryote cell. These studies, however, must be complemented by cell biology and biochemical approaches to appreciate the ...
Saiardi, A
core   +3 more sources

Monitoring Phytate Hydrolysis Using Serial Blood Sampling and Feather Myo-Inositol Levels in Broilers

Frontiers in Physiology, 2020
Phytate forms insoluble precipitates with various cations that are recalcitrant to digestion in poultry. Dietary supplementation with exogenous phytase has been shown to improve phytate solubility and digestibility and, in turn, improve animal growth ...
Elizabeth Greene, Barbara Mallmann, Jonathan W. Wilson, Aaron J. Cowieson, Sami Dridi   +4 more
doaj   +1 more source

A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]

, 2017
Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla, Jao, Li-En, Wente, Susan R   +2 more
core   +1 more source

Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate

International Journal of Endocrinology, 2016
Inositols (myo-inositol and inositol hexakisphosphate) exert a wide range of critical activities in both physiological and pathological settings. Deregulated inositol metabolism has been recorded in a number of diseases, including cancer, where inositol ...
Mariano Bizzarri, Simona Dinicola, Arturo Bevilacqua, Alessandra Cucina   +3 more
doaj   +1 more source