Results 11 to 20 of about 3,089 (138)

Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair. [PDF]

J Biol Chem, 2013
Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP(7)), are water-soluble inositol phosphates that contain high energy diphosphate moieties on the inositol ring. Inositol hexakisphosphate kinase 1 (IP6K1) participates in inositol pyrophosphate synthesis, converting inositol hexakisphosphate (IP(6)) to IP(7).
Jadav RS, Chanduri MV, Sengupta S, Bhandari R.   +3 more
europepmc   +6 more sources

Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. [PDF]

Nat Immunol, 2011
Inositol phosphates are widely produced throughout animal and plant tissues. Diphosphoinositol pentakisphosphate (InsP7) contains an energetic pyrophosphate bond. Here we demonstrate that disruption of inositol hexakisphosphate kinase 1 (InsP6K1), one of the three mammalian inositol hexakisphosphate kinases (InsP6Ks) that convert inositol ...
Prasad A, Jia Y, Chakraborty A, Li Y, Jain SK, Zhong J, Roy SG, Loison F, Mondal S, Sakai J, Blanchard C, Snyder SH, Luo HR.   +12 more
europepmc   +8 more sources

Insights into the roles of inositol hexakisphosphate kinase 1 (IP6K1) in mammalian cellular processes. [PDF]

J Biol Chem
Inositol phosphates and their metabolites play a significant role in several biochemical pathways, gene expression regulation, and phosphate homeostasis. Among the different inositol phosphates, inositol hexakisphosphate (IP6) is a substrate of inositol hexakisphosphate kinases (IP6Ks), which phosphorylate one or more of the IP6 phosphate groups ...
Chakkour M, Greenberg ML.
europepmc   +5 more sources

Ingestion of lean meat elevates muscle inositol hexakisphosphate kinase 1 protein content independent of a distinct post-prandial circulating proteome in young adults with obesity. [PDF]

Metabolism, 2020
We have recently shown that a novel signalling kinase, inositol hexakisphosphate kinase 1 (IP6K1), is implicated in whole-body insulin resistance via its inhibitory action on Akt. Insulin and insulin like growth factor 1 (IGF-1) share many intracellular processes with both known to play a key role in glucose and protein metabolism in skeletal muscle.We
Barclay RD, Beals JW, Drnevich J, Imai BS, Yau PM, Ulanov AV, Tillin NA, Villegas-Montes M, Paluska SA, Watt PW, De Lisio M, Burd NA, Mackenzie RW.   +12 more
europepmc   +6 more sources

Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice. [PDF]

Cell Signal, 2016
Inositol hexakisphosphate kinases (IP6Ks), a family of enzymes found in all eukaryotes, are responsible for the synthesis of 5-diphosphoinositol pentakisphosphate (5-IP7) from inositol hexakisphosphate (IP6). Three isoforms of IP6Ks are found in mammals, and gene deletions of each isoform lead to diverse, non-overlapping phenotypes in mice.
Jadav RS, Kumar D, Buwa N, Ganguli S, Thampatty SR, Balasubramanian N, Bhandari R.   +6 more
europepmc   +5 more sources

Inositol hexakisphosphate kinase 1 is implicated in the insulin response to protein ingestion in older adults [PDF]

Scientific Reports
Age-related muscle mass is driven by a reduction in insulin sensitivity partly mediated by reduced amino acid and anabolic signalling kinetics. Insulin activates Akt-mTORC1 signalling in skeletal muscle, with inositol hexakisphosphate kinase 1 (IP6K1 ...
Richie D. Barclay, Diana E. Motei, Oana Ancu, Christopher J. Tyler, Neale A. Tillin, Volker Behrends, Nicholas A. Burd, Nicholas M. Hurren, Richard W.A. Mackenzie   +8 more
doaj   +2 more sources

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes [PDF]

Diabetes, Metabolic Syndrome and Obesity, 2014
Richard WA Mackenzie, Bradley T Elliott Department of Human and Health Sciences, Facility of Science and Technology, University of Westminster, London, UK Abstract: Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin ...
Mackenzie RWA, Elliott BT
doaj   +6 more sources

Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels [PDF]

Blood, 2013
Key Points Inositol hexakisphosphate kinase 1 (IP6K1) knockout mice display lower inorganic polyphosphate levels in platelets. Low platelet polyphosphate leads to lengthened clotting time, altered clot architecture, and protection against pulmonary thromboembolism.
Somadri, Ghosh, Dhananjay, Shukla, Komjeti, Suman, B Jyothi, Lakshmi, R, Manorama, Satish, Kumar, Rashna, Bhandari   +6 more
openaire   +4 more sources

Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis [PDF]

Proceedings of the National Academy of Sciences, 2008
Inositol pyrophosphates, also designated inositol diphosphates, possess high-energy β-phosphates that can pyrophosphorylate proteins and regulate various cellular processes. They are formed by a family of inositol hexakisphosphate kinases (IP6Ks). We have created mice with a targeted deletion of IP6K1 in which production of inositol pyrophosphates is ...
Rashna, Bhandari, Krishna R, Juluri, Adam C, Resnick, Solomon H, Snyder   +3 more
openaire   +4 more sources

Molecular modeling, dynamics simulation and characterization of human inositol hexakisphosphate kinase 1 (IP6K1) related to diabetes

Journal of Applied Sciences and Environmental Management, 2019
Inositol hexakisphosphate kinase-1 (IP6K1) protein plays an important role in insulin signaling producing IP7 that inhibit the action of protein kinase B (Akt).
O.O. Elekofehinti, Y.V. Aladenika, Y.R. Alli-Smith, O.C. Ejelonu, A.O. Lawal   +4 more
doaj   +3 more sources