Results 11 to 20 of about 107,826,167 (138)

Inositol Hexakisphosphate Kinase 1 Regulates Neutrophil Function in Innate Immunity by Inhibiting Phosphatidylinositol-(3,4,5)-Trisphosphate Signaling [PDF]

Nature Immunology, 2011
Inositol phosphates are widely produced throughout animal and plant tissues. Diphosphoinositol pentakisphosphate (InsP7) contains an energetic pyrophosphate bond. Here we demonstrate that disruption of inositol hexakisphosphate kinase 1 (InsP6K1), one of the three mammalian inositol hexakisphosphate kinases (InsP6Ks) that convert inositol ...
Anutosh Chakraborty, Subhanjan Mondal, Fabien Loison   +2 more
exaly   +9 more sources

Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport. [PDF]

Biochem J, 2016
Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP7), are conserved eukaryotic signaling molecules that possess pyrophosphate and monophosphate moieties. Generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine pyrophosphorylation. Here,
Chanduri M, Rai A, Malla AB, Wu M, Fiedler D, Mallik R, Bhandari R.   +6 more
europepmc   +5 more sources

Deletion of Inositol Hexakisphosphate Kinase 1 (IP6K1) Reduces Cell Migration and Invasion, Conferring Protection From Aerodigestive Tract Carcinoma in Mice [PDF]

Cellular Signalling, 2016
Inositol hexakisphosphate kinases (IP6Ks), a family of enzymes found in all eukaryotes, are responsible for the synthesis of 5-diphosphoinositol pentakisphosphate (5-IP7) from inositol hexakisphosphate (IP6). Three isoforms of IP6Ks are found in mammals, and gene deletions of each isoform lead to diverse, non-overlapping phenotypes in mice.
Nagaraj Balasubramanian, Natasha Buwa, Rashna Bhandari   +2 more
exaly   +4 more sources

Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate [PDF]

International Journal of Endocrinology, 2016
Inositols (myo-inositol and inositol hexakisphosphate) exert a wide range of critical activities in both physiological and pathological settings. Deregulated inositol metabolism has been recorded in a number of diseases, including cancer, where inositol ...
Mariano Bizzarri, Simona Dinicola, Arturo Bevilacqua, Alessandra Cucina   +3 more
doaj   +2 more sources

Molecular modeling, dynamics simulation and characterization of human inositol hexakisphosphate kinase 1 (IP6K1) related to diabetes

Journal of Applied Sciences and Environmental Management, 2019
Inositol hexakisphosphate kinase-1 (IP6K1) protein plays an important role in insulin signaling producing IP7 that inhibit the action of protein kinase B (Akt).
O.O. Elekofehinti, Y.V. Aladenika, Y.R. Alli-Smith, O.C. Ejelonu, A.O. Lawal   +4 more
doaj   +3 more sources

Primate lentiviruses require Inositol hexakisphosphate (IP6) or inositol pentakisphosphate (IP5) for the production of viral particles.

PLoS Pathogens, 2020
Inositol hexakisphosphate (IP6) potently stimulates HIV-1 particle assembly in vitro and infectious particle production in vivo. However, knockout cells lacking inositol-pentakisphosphate 2-kinase (IPPK-KO), the enzyme that produces IP6 by ...
Clifton L Ricana, Terri D Lyddon, Robert A Dick, Marc C Johnson   +3 more
doaj   +2 more sources

Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis. [PDF]

Int J Biochem Cell Biol, 2016
Lipolysis leads to the breakdown of stored triglycerides (TAG) to release free fatty acids (FFA) and glycerol which is utilized by energy expenditure pathways to generate energy. Therefore, a decrease in lipolysis augments fat accumulation in adipocytes which promotes weight gain.
Ghoshal S, Tyagi R, Zhu Q, Chakraborty A.   +3 more
europepmc   +4 more sources

Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells. [PDF]

J Biol Chem, 2016
myo-Inositol, the precursor of all inositol compounds, has pivotal roles in cell metabolism and signaling pathways. Although physiological studies indicate a strong correlation between abnormal intracellular inositol levels and neurological disorders, very little is known about the regulation of inositol synthesis in mammalian cells.
Yu W, Ye C, Greenberg ML.
europepmc   +4 more sources

Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.

Cell Signal, 2018
Diphosphoinositol pentakisphosphate (IP7) is critical for the exocytotic capacity of the pancreatic β-cell, but its regulation by the primary instigator of β-cell exocytosis, glucose, is unknown. The high Km for ATP of the IP7-generating enzymes, the inositol hexakisphosphate kinases (IP6K1 and 2) suggests that these enzymes might serve as metabolic ...
Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, Ferreira SS, Ferreira SS, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO.   +16 more
europepmc   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates - detection, function, and regulation. [PDF]

FEBS Lett
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Lampe S, Mohanty TK, Bhandari R, Fiedler D.   +3 more
europepmc   +2 more sources