Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants? [PDF]
Molecules, 2020 The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Caitlin Cridland, Glenda Gillaspy
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Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81 [PDF]
eLife, 2023 Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert +7 more
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Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis. [PDF]
PLoS ONE, 2014 The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Francesca Pisani +5 more
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Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast [PDF]
mBioInositol pyrophosphates 5-IP7, 1-IP7, and 1,5-IP8 are eukaryal signaling molecules that influence cell physiology, especially phosphate homeostasis. In fission yeast, 1,5-IP8 and 1-IP7 impact gene expression by acting as agonists of RNA 3'-processing and
Beate Schwer +5 more
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Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7 [PDF]
Biomolecules, 2023 Inositol pyrophosphates (PP-InsPs); are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code.
Soumyadip Sahu +6 more
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Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in Saccharomyces cerevisiae [PDF]
BiomoleculesThe inositol pyrophosphate pathway, a complex cell signaling network, plays a pivotal role in orchestrating vital cellular processes in the budding yeast, where it regulates cell cycle progression, growth, endocytosis, exocytosis, apoptosis, telomere ...
Larisa Ioana Gogianu +2 more
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Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development. [PDF]
PLoS GeneticsInositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8.
Florian Laurent +10 more
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Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases [PDF]
Molecules, 2020 In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated
Sandip Mukherjee +2 more
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Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus [PDF]
The EMBO JournalKinases that synthesize inositol phosphates (IPs) and pyrophosphates (PP-IPs) control numerous biological processes in eukaryotic cells. Herein, we extend this cellular signaling repertoire to viruses. We have biochemically and structurally characterized
Guangning Zong +6 more
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Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States [PDF]
mBio, 2022 Expression of the fission yeast Schizosaccharomyces pombe phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate signaling molecule 1,5-IP8.
Bradley Benjamin +5 more
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