Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals [PDF]
Molecules, 2020 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds.
Min Gyu Kim, Seulgi Lee, Seyun Kim
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Biosynthesis and possible functions of inositol pyrophosphates in plants [PDF]
Frontiers in Plant Science, 2015 Inositol phosphates (InsPs) are intricately tied to lipid signaling, as at least one portion of the inositol phosphate signaling pool is derived from hydrolysis of the lipid precursor, phosphatidyl inositol (4,5) bisphosphate. The focus of this review is
Sarah Phoebe Williams +2 more
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Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops? [PDF]
Plants, 2020 Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed +2 more
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Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase [PDF]
Molecules, 2021 IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao +5 more
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Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues [PDF]
Molecules, 2020 Inositol pyrophosphates (PP-InsPs) comprise an important group of intracellular, diffusible cellular signals that a wide range of biological processes throughout the yeast, plant, and animal kingdoms.
Stephen B. Shears, Huanchen Wang
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Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants [PDF]
Advanced ScienceInositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in ...
Kevin Ritter +10 more
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Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response. [PDF]
PLoS Pathogens, 2014 The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of RIG-
Niyas Kudukkil Pulloor +16 more
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Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction [PDF]
Nature Communications, 2023 Many proteins involved in eukaryotic phosphate homeostasis are regulated by SPX domains. In yeast, the vacuolar transporter chaperone (VTC) complex contains two such domains, but mechanistic details of its regulation are not well understood.
Joka Pipercevic +10 more
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A Role for Inositol Pyrophosphates in the Metabolic Adaptations to Low Phosphate in Arabidopsis [PDF]
Metabolites, 2021 Phosphate is a major plant macronutrient and low phosphate availability severely limits global crop productivity. In Arabidopsis, a key regulator of the transcriptional response to low phosphate, phosphate starvation response 1 (PHR1), is modulated by a ...
Eric S. Land +7 more
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Pho84/GLUT2 are cellular myo-inositol exporters regulated by inositol pyrophosphates [PDF]
The EMBO JournalInositol is an essential nutrient for most living organisms, as combinatorial phosphorylation on this cyclic sugar generates key cellular messengers, such as lipid-bound phosphoinositides (PtdInsPs), water-soluble inositol phosphates (InsPs), and high ...
Xue Bessie Su +6 more
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