Inositol pyrophosphates: Why so many phosphates? [PDF]
Advances in Biological Regulation, 2015 The inositol pyrophosphates (PP-InsPs) are a specialized group of "energetic" signaling molecules found in yeasts, plants and animals. PP-InsPs boast the most crowded three dimensional phosphate arrays found in Nature; multiple phosphates and diphosphates are crammed around the six-carbon, inositol ring.
Stephen B Shears
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Inositol Pyrophosphates as Mammalian Cell Signals [PDF]
Science Signaling, 2011 Identification and knockout of their biosynthetic enzymes has shed light on the diverse functions of the inositol pyrophosphates.
Anutosh Chakraborty +2 more
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Regulation of Inositol Metabolism Is Fine-tuned by Inositol Pyrophosphates in Saccharomyces cerevisiae* [PDF]
Journal of Biological Chemistry, 2013 Although inositol pyrophosphates have diverse roles in phosphate signaling and other important cellular processes, little is known about their functions in the biosynthesis of inositol and phospholipids. Here, we show that KCS1, which encodes an inositol pyrophosphate kinase, is a regulator of inositol metabolism.
Cunqi Ye, Miriam L Greenberg
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Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast [PDF]
mBioInositol pyrophosphates 5-IP7, 1-IP7, and 1,5-IP8 are eukaryal signaling molecules that influence cell physiology, especially phosphate homeostasis. In fission yeast, 1,5-IP8 and 1-IP7 impact gene expression by acting as agonists of RNA 3'-processing and
Beate Schwer +5 more
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Advanced ScienceInositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in ...
Kevin Ritter +10 more
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Animal Cells and Systems, 2018 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park, Seulgi Lee, Seyun Kim
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Inositol Pyrophosphates Regulate Cell Growth and the Environmental Stress Response by Activating the HDAC Rpd3L [PDF]
Cell Reports, 2013 Cells respond to stress and starvation by adjusting their growth rate and enacting stress defense programs. In eukaryotes this involves inactivation of TORC1, which in turn triggers downregulation of ribosome and protein synthesis genes and upregulation ...
Jeremy Worley +2 more
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A linear pathway for inositol pyrophosphate metabolism revealed by 18O labeling and model reduction. [PDF]
PLoS Computational BiologyThe homeostasis of intracellular inorganic phosphate is essential for eukaryotic metabolism and is regulated by the INPHORS signalling pathway, which employs inositol pyrophosphates (IPPs) as key intermediary messengers.
Jacques Hermes +6 more
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Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling [PDF]
Journal of Cellular Physiology, 2018 Stephen B Shears
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Preparation of quality inositol pyrophosphates. [PDF]
J Vis Exp, 2011 Myo-inositol is present in nature either unmodified or in more complex phosphorylated derivates. Of the latest, the two most abundant in eukaryotic cells are inositol pentakisphosphate (IP(5;)) and inositol hexakisphosphate (phytic acid or IP(6;)).
Loss O +4 more
europepmc +4 more sources