Results 11 to 20 of about 38,827 (170)
Animal Cells and Systems, 2018 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park, Seulgi Lee, Seyun Kim
exaly +3 more sources
Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies [PDF]
Advanced ScienceInositol phosphates (InsPs) and inositol pyrophosphates (PP‐InsPs) constitute a remarkably diverse yet evolutionarily conserved signaling network generated through combinatorial phosphorylation of myo‐inositol.
Adolfo Saiardi +5 more
doaj +3 more sources
Inositol pyrophosphates as mammalian cell signals. [PDF]
Sci Signal, 2011 Identification and knockout of their biosynthetic enzymes has shed light on the diverse functions of the inositol pyrophosphates.
Chakraborty A, Kim S, Snyder SH.
europepmc +5 more sources
Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis. [PDF]
PLoS ONE, 2009 BackgroundInositol pyrophosphates are a recently characterized cell signalling molecules responsible for the pyrophosphorylation of protein substrates. Though likely involved in a wide range of cellular functions, the study of inositol pyrophosphates has
Oriana Losito +3 more
doaj +2 more sources
Inositol pyrophosphates: Why so many phosphates? [PDF]
Advances in Biological Regulation, 2015 The inositol pyrophosphates (PP-InsPs) are a specialized group of "energetic" signaling molecules found in yeasts, plants and animals. PP-InsPs boast the most crowded three dimensional phosphate arrays found in Nature; multiple phosphates and diphosphates are crammed around the six-carbon, inositol ring.
Stephen B Shears
exaly +5 more sources
Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis. [PDF]
PLoS ONE, 2014 The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Francesca Pisani +5 more
doaj +2 more sources
Regulation of Inositol Metabolism Is Fine-tuned by Inositol Pyrophosphates in Saccharomyces cerevisiae*♦ [PDF]
Journal of Biological Chemistry, 2013 Although inositol pyrophosphates have diverse roles in phosphate signaling and other important cellular processes, little is known about their functions in the biosynthesis of inositol and phospholipids. Here, we show that KCS1, which encodes an inositol pyrophosphate kinase, is a regulator of inositol metabolism.
Miriam L Greenberg, Cunqi Ye
exaly +5 more sources
Inositol pyrophosphate kinases in health and disease. [PDF]
FEBS LettIn mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Xing C +6 more
europepmc +4 more sources
Inositol Pyrophosphates in Metabolism Control
Science Signaling, 2011 Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
L. Bryan Ray
core +3 more sources
Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates [PDF]
Biochemistry, 2019 The inositol pyrophosphates (PP-InsPs) are an important group of cellular messengers that influence a broad range of biological processes. To elucidate the functions of these high-energy metabolites at the biochemical level, access to the purified molecules is required.
Robert Puschmann +2 more
openaire +3 more sources