Results 21 to 30 of about 751 (180)

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

Nature Communications, 2023
Many proteins involved in eukaryotic phosphate homeostasis are regulated by SPX domains. In yeast, the vacuolar transporter chaperone (VTC) complex contains two such domains, but mechanistic details of its regulation are not well understood.
Joka Pipercevic, Bastian Kohl, Ruta Gerasimaite, Véronique Comte-Miserez, Sarah Hostachy, Thomas Müntener, Elia Agustoni, Henning Jacob Jessen, Dorothea Fiedler, Andreas Mayer, Sebastian Hiller   +10 more
doaj   +2 more sources

Arabidopsis PFA-DSP-type phosphohydrolases target specific inositol pyrophosphate messengers

, 2022
Inositol pyrophosphates are signaling molecules containing at least one phosphoanhydride bond that regulate a wide range of cellular processes in eukaryotes.
Liu, Guizhen, Schaaf, Gabriel, Laha, Debabrata, Ritter, Kevin, Jessen, Henning, Häner, Markus, Weber, Jonathan, Fernandez-Rebollo, Nicolas, Yadav, Ranjana, Schmid, Jochen, Trung, Minh Nguyen, Schneider, Robin, Gaugler, Philipp, Gaugler, Verena, Fiedler, Dorothea, Qiu, Danye, Giehl, Ricardo F. H., Jork, Nikolaus   +17 more
core   +3 more sources

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +2 more sources

Towards pharmacological intervention in inositol pyrophosphate signalling [PDF]

Biochemical Society Transactions, 2016
To help define the molecular basis of cellular signalling cascades, and their biological functions, there is considerable value in utilizing a high-quality chemical ‘probe’ that has a well-defined interaction with a specific cellular protein. Such reagents include inhibitors of protein kinases and small molecule kinases, as well as mimics or ...
Stephen B. Shears
openaire   +4 more sources

Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues

Molecules, 2020
Inositol pyrophosphates (PP-InsPs) comprise an important group of intracellular, diffusible cellular signals that a wide range of biological processes throughout the yeast, plant, and animal kingdoms.
Stephen B. Shears, Huanchen Wang
doaj   +2 more sources

Analysis and Quantification of Inositol Poly- and Pyrophosphates by NMR Spectroscopy and Mass Spectrometry [PDF]

, 2020
Inositolpyrophosphate (PP-InsP) sind eine Gruppe sekundärer Signalmoleküle, die in einer Vielzahl zellulärer Prozesse, von Phosphathomeostase über Insulinsignalisierung bis Apoptose eine Rolle spielen.
Puschmann, Robert
core   +3 more sources

Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus

The EMBO Journal
Kinases that synthesize inositol phosphates (IPs) and pyrophosphates (PP-IPs) control numerous biological processes in eukaryotic cells. Herein, we extend this cellular signaling repertoire to viruses. We have biochemically and structurally characterized
Guangning Zong, Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon, Adolfo Saiardi, Stephen B. Shears, Huanchen Wang   +6 more
doaj   +2 more sources

Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs [PDF]

Chemistry – A European Journal, 2023
AbstractInositol pyrophosphates (PP−IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP−IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo‐inositol ring. 5PP−IP5 is the most abundant PP−IP in human cells. To investigate the function and regulation by PP−IPs in biological contexts,
Sarah Hostachy, Huanchen Wang, Guangning Zong, Katy Franke, Andrew M. Riley, Peter Schmieder, Barry V. L. Potter, Stephen B. Shears, Dorothea Fiedler   +8 more
openaire   +5 more sources

Fungal Inositol Pyrophosphate IP₇ Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity

mBio, 2015
Inositol pyrophosphates (PP-IPs) comprising inositol, phosphate, and pyrophosphate (PP) are essential for multiple functions in eukaryotes. Their role in fungal pathogens has never been addressed.
Sophie Lev, Cecilia Li, Desmarini Desmarini, Adolfo Saiardi, Nicole L. Fewings, Stephen D. Schibeci, Raghwa Sharma, Tania C. Sorrell, Julianne T. Djordjevic   +8 more
doaj   +2 more sources

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

eLife, 2019
Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate Pi homeostasis.
Jinsheng Zhu, Kelvin Lau, Robert Puschmann, Robert K Harmel, Youjun Zhang, Verena Pries, Philipp Gaugler, Larissa Broger, Amit K Dutta, Henning J Jessen, Gabriel Schaaf, Alisdair R Fernie, Ludwig A Hothorn, Dorothea Fiedler, Michael Hothorn   +14 more
doaj   +2 more sources