Influence of Inositol Pyrophosphates on Cellular Energy Dynamics
Science, 2011 Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
Zsolt, Szijgyarto +3 more
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Emerging roles of inositol pyrophosphates as key modulators of fungal pathogenicity [PDF]
Virulence, 2018 Inositol pyrophosphates (PP-IPs) are energy-rich small molecules that are omnipresent in eukaryotic cells, from yeast to mammals, playing central roles in overall cellular homeostasis as a diverse and multifaceted class of intracellular messengers ...
Hyun Ah Kang
doaj +2 more sources
Proteome-wide quantification of inositol pyrophosphate-protein interactions [PDF]
Nature CommunicationsInositol polyphosphates (InsPs) and inositol pyrophosphates (PP-InsPs) are highly phosphorylated signaling molecules involved in diverse cellular processes.
Annika Richter +7 more
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Inositol pyrophosphates: structure, enzymology and function
Cellular and Molecular Life Sciences, 2009 The stereochemistry of the inositol backbone provides a platform on which to generate a vast array of distinct molecular motifs that are used to convey information both in signal transduction and many other critical areas of cell biology. Diphosphoinositol phosphates, or inositol pyrophosphates, are the most recently characterized members of the ...
Christopher John, Barker +3 more
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Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?
Molecules, 2020 The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Glenda Gillaspy, Caitlin Cridland
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Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast [PDF]
mBioInositol pyrophosphates 5-IP7, 1-IP7, and 1,5-IP8 are eukaryal signaling molecules that influence cell physiology, especially phosphate homeostasis. In fission yeast, 1,5-IP8 and 1-IP7 impact gene expression by acting as agonists of RNA 3'-processing and
Beate Schwer +5 more
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Protein pyrophosphorylation by inositol pyrophosphates - detection, function, and regulation. [PDF]
FEBS LettProtein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Lampe S +3 more
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Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates. [PDF]
FEBS LettInositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Rolfes RJ.
europepmc +2 more sources
Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules. [PDF]
J Indian Inst Sci, 2017 Inositol pyrophosphates (PP-IPs) are a class of energy-rich signalling molecules found in all eukaryotic cells. These are derivatives of inositol that contain one or more diphosphate (or pyrophosphate) groups in addition to monophosphates.
Shah A, Ganguli S, Sen J, Bhandari R.
europepmc +3 more sources
Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling [PDF]
Journal of Cellular Physiology, 2018 Stephen B Shears
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