Results 21 to 30 of about 903 (153)
eLife, 2023 Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert +7 more
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Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis. [PDF]
Proc Natl Acad Sci U S A, 2016 Significance Inositol phosphates have long been considered to be negative regulators of synaptic exocytosis, but the function of diphosphoinositol pentakisphosphate (IP 7 ) has remained elusive. We found that overexpression and depletion of inositol hexakisphosphate (IP
Lee TS +14 more
europepmc +6 more sources
Inositol Pyrophosphate Pyrotechnics [PDF]
Cell Metabolism, 2007 Physiologic roles of highly phosphorylated inositol phosphates, including those containing pyrophosphate groups, have been the focus of much recent interest. In the April 6, 2007 issue of Science, two papers (Lee et al., 2007; Mulugu et al., 2007) demonstrate the occurrence of a novel inositol pyrophosphate molecule in yeast and elucidate its role in ...
Bhandari, Rashna +2 more
openaire +2 more sources
The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. [PDF]
PLoS Genetics, 2014 Microtubules (MTs) are pivotal for numerous eukaryotic processes ranging from cellular morphogenesis, chromosome segregation to intracellular transport. Execution of these tasks requires intricate regulation of MT dynamics.
Jennifer Pöhlmann +11 more
doaj +1 more source
Nature Communications, 2022 Inositol pyrophosphates (PP-IPs) regulate immunity and phosphate homeostasis. Here, the authors’ structural dissection of an Arabidopsis thaliana PP-IP phosphatase reveals that substrates drive their own hydrolysis and identifies a highly elusive ...
Huanchen Wang +7 more
doaj +1 more source
Metabolic Consequences of Polyphosphate Synthesis and Imminent Phosphate Limitation
mBio, 2023 Cells stabilize intracellular inorganic phosphate (Pi) to compromise between large biosynthetic needs and detrimental bioenergetic effects of Pi.
Geun-Don Kim +3 more
doaj +1 more source
Structural insight into inositol pyrophosphate turnover [PDF]
Advances in Biological Regulation, 2013 The diphosphoinositol polyphosphates ("inositol pyrophosphates"; PP-InsPs) regulate many cellular processes in eukaryotes, including stress responses, apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, telomere maintenance, insulin signaling and neutrophil activation.
Stephen B, Shears +2 more
openaire +2 more sources
Regulation of plant biotic interactions and abiotic stress responses by inositol polyphosphates
Frontiers in Plant Science, 2022 Inositol pyrophosphates (PP-InsPs), derivatives of inositol hexakisphosphate (phytic acid, InsP6) or lower inositol polyphosphates, are energy-rich signaling molecules that have critical regulatory functions in eukaryotes. In plants, the biosynthesis and
Esther Riemer +7 more
doaj +1 more source
Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis.
PLoS ONE, 2014 The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Francesca Pisani +5 more
doaj +1 more source
mBio, 2022 Inositol pyrophosphates (IPPs) are signaling molecules that regulate cellular phosphate homeostasis in diverse eukaryal taxa. In fission yeast, mutations that increase 1,5-IP8 derepress the PHO regulon while mutations that ablate IP8 synthesis are PHO ...
Bradley Benjamin +5 more
doaj +1 more source