Results 31 to 40 of about 38,827 (170)
Preparation of quality inositol pyrophosphates. [PDF]
J Vis Exp, 2011 Myo-inositol is present in nature either unmodified or in more complex phosphorylated derivates. Of the latest, the two most abundant in eukaryotic cells are inositol pentakisphosphate (IP(5;)) and inositol hexakisphosphate (phytic acid or IP(6;)).
Loss O +4 more
europepmc +4 more sources
Enabling Technologies for the Dissection of Inositol Pyrophosphate Physiology
The diverse chemical structures of inositol pyrophosphates attract growing interest toward this class of small molecule messengers. However, their highly charged nature, the lack of a chromophore or a fluorophore, their close structural relatedness, and the complexity of their metabolism pose serious challenges to inositol pyrophosphates studies. Here,
Adolfo, Saiardi +2 more
core +4 more sources
eLife, 2023 Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert +7 more
doaj +1 more source
Inositol Pyrophosphate Pyrotechnics [PDF]
Cell Metabolism, 2007 Physiologic roles of highly phosphorylated inositol phosphates, including those containing pyrophosphate groups, have been the focus of much recent interest. In the April 6, 2007 issue of Science, two papers (Lee et al., 2007; Mulugu et al., 2007) demonstrate the occurrence of a novel inositol pyrophosphate molecule in yeast and elucidate its role in ...
Bhandari, Rashna +2 more
openaire +2 more sources
Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis. [PDF]
Proc Natl Acad Sci U S A, 2016 Significance Inositol phosphates have long been considered to be negative regulators of synaptic exocytosis, but the function of diphosphoinositol pentakisphosphate (IP 7 ) has remained elusive. We found that overexpression and depletion of inositol hexakisphosphate (IP
Lee TS +14 more
europepmc +6 more sources
The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. [PDF]
PLoS Genetics, 2014 Microtubules (MTs) are pivotal for numerous eukaryotic processes ranging from cellular morphogenesis, chromosome segregation to intracellular transport. Execution of these tasks requires intricate regulation of MT dynamics.
Jennifer Pöhlmann +11 more
doaj +1 more source
Nature Communications, 2022 Inositol pyrophosphates (PP-IPs) regulate immunity and phosphate homeostasis. Here, the authors’ structural dissection of an Arabidopsis thaliana PP-IP phosphatase reveals that substrates drive their own hydrolysis and identifies a highly elusive ...
Huanchen Wang +7 more
doaj +1 more source
Metabolic Consequences of Polyphosphate Synthesis and Imminent Phosphate Limitation
mBio, 2023 Cells stabilize intracellular inorganic phosphate (Pi) to compromise between large biosynthetic needs and detrimental bioenergetic effects of Pi.
Geun-Don Kim +3 more
doaj +1 more source
Regulation of plant biotic interactions and abiotic stress responses by inositol polyphosphates
Frontiers in Plant Science, 2022 Inositol pyrophosphates (PP-InsPs), derivatives of inositol hexakisphosphate (phytic acid, InsP6) or lower inositol polyphosphates, are energy-rich signaling molecules that have critical regulatory functions in eukaryotes. In plants, the biosynthesis and
Esther Riemer +7 more
doaj +1 more source
Inositol Pyrophosphates Get the Vip1 Treatment [PDF]
Cell, 2007 Inositol pyrophosphates are unique signaling molecules implicated in the regulation of diverse cellular processes. Two new studies by Mulugu et al. (2007) and Lee et al. (2007) extend the biological and metabolic diversity of this class of molecules. They identify yeast Vip1 as a new inositol pyrophosphate synthase and show that the products of Vip1 ...
Onnebo, Sara Maria Nancy +1 more
openaire +2 more sources