Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling [PDF]
Biomolecules, 2023 Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being ...
Jia Yu +6 more
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Phytase dose-dependent response of kidney inositol phosphate levels in poultry [PDF]
PLoS ONE, 2022 Phytases, enzymes that degrade phytate present in feedstuffs, are widely added to the diets of monogastric animals. Many studies have correlated phytase addition with improved animal productivity and a subset of these have sought to correlate animal ...
Colleen Sprigg +5 more
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Co-culturing experiments reveal the uptake of myo-inositol phosphate synthase (EC 5.5.1.4) in an inositol auxotroph of Saccharomyces cerevisiae [PDF]
Microbial Cell Factories, 2021 Background Myo-Inositol Phosphate Synthase (MIP) catalyzes the conversion of glucose 6- phosphate into inositol phosphate, an essential nutrient and cell signaling molecule.
Erika Steele +4 more
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Role of Inositols and Inositol Phosphates in Energy Metabolism [PDF]
Molecules, 2020 Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Saimai Chatree +4 more
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The intracellular inositol (pyro)phosphate receptor AtSPX1 reciprocally binds to P1BS DNA [PDF]
Nature CommunicationsThe response of plants to phosphate starvation engages PHR (CC-MYB-PHOSPHATE STARVATION RESPONSE) transcription factors that bind to P1BS (GNATATNC) promoter elements of phosphate-starvation induced (PSI) genes. The encoded proteins include single-domain
Hayley L. Whitfield +6 more
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eLife, 2023 Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert +7 more
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MLKL Requires the Inositol Phosphate Code to Execute Necroptosis [PDF]
Molecular Cell, 2018 Jonathan Diep +2 more
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Bioactivity of Inositol Phosphates [PDF]
Molecules, 2021 Inositol phosphates (IPs) are a huge and complex family of biomolecules, important in regulating vital cellular functions, signal transduction, energy transmission, and ion channels physiology and serving as structural components of cell membranes [...]
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A Solanum tuberosum inositol phosphate kinase (StITPK1) displaying inositol phosphate–inositol phosphate and inositol phosphate–ADP phosphotransferase activities [PDF]
FEBS Letters, 2008 We describe a multifunctional inositol polyphosphate kinase/phosphotransferase from Solanum tuberosum, StITPKα (GenBank accession number: EF362784), hereafter called StITPK1. StITPK1 displays inositol 3,4,5,6‐tetrakisphosphate 1‐kinase activity: K m = 27 μM, and V max = 19 nmol min−1 mg−1.
Caddick, Samuel E. K. +5 more
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Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?
Plants, 2020 Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed +2 more
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