Results 1 to 10 of about 494,776 (288)

Role of Inositols and Inositol Phosphates in Energy Metabolism [PDF]

Molecules, 2020
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Saimai Chatree, Nanthaphop Thongmaen, Kwanchanit Tantivejkul, Chantacha Sitticharoon, Ivana Vucenik   +4 more
doaj   +5 more sources

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling [PDF]

Biomolecules, 2023
Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being ...
Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B. Shears, Ingo B. Leibiger, Per-Olof Berggren, Christopher J. Barker   +6 more
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Co-culturing experiments reveal the uptake of myo-inositol phosphate synthase (EC 5.5.1.4) in an inositol auxotroph of Saccharomyces cerevisiae [PDF]

Microbial Cell Factories, 2021
Background Myo-Inositol Phosphate Synthase (MIP) catalyzes the conversion of glucose 6- phosphate into inositol phosphate, an essential nutrient and cell signaling molecule.
Erika Steele, Hana D. Alebous, Macy Vickers, Mary E. Harris, Margaret D. Johnson   +4 more
doaj   +2 more sources

Phytase dose-dependent response of kidney inositol phosphate levels in poultry. [PDF]

PLoS ONE, 2022
Phytases, enzymes that degrade phytate present in feedstuffs, are widely added to the diets of monogastric animals. Many studies have correlated phytase addition with improved animal productivity and a subset of these have sought to correlate animal ...
Colleen Sprigg, Hayley Whitfield, Emily Burton, Dawn Scholey, Michael R Bedford, Charles A Brearley   +5 more
doaj   +3 more sources

Pho84/GLUT2 are cellular myo-inositol exporters regulated by inositol pyrophosphates [PDF]

The EMBO Journal
Inositol is an essential nutrient for most living organisms, as combinatorial phosphorylation on this cyclic sugar generates key cellular messengers, such as lipid-bound phosphoinositides (PtdInsPs), water-soluble inositol phosphates (InsPs), and high ...
Xue Bessie Su, Xinjie Zhang, Valeria Fedeli, An-Li Andrea Ko, Jiarui Nicole Fu, Dorothea Fiedler, Adolfo Saiardi   +6 more
doaj   +2 more sources

Cellular adaptations of fission yeast to inositol starvation [PDF]

mBio
Inositol is an essential nutrient and a precursor of phosphorylated metabolites that play important roles in cell physiology. Here we characterize the impact of intracellular inositol deficiency, taking advantage of fission yeast Schizosaccharomyces ...
Ana M. Sanchez, Jill Babor, Michelle Saoi, Isabel Prucker, Henning J. Jessen, Beate Schwer, Stewart Shuman   +6 more
doaj   +2 more sources

Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81

eLife, 2023
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert, Geun-Don Kim, Danye Qiu, Guizhen Liu, Lydie Michaillat Mayer, Muhammed Jamsheer K, Henning J Jessen, Andreas Mayer   +7 more
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Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?

Plants, 2020
Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed, Olusegun Adepoju, Glenda Gillaspy   +2 more
doaj   +1 more source

Metabolic engineering of Pichia pastoris for myo-inositol production by dynamic regulation of central metabolism

Microbial Cell Factories, 2022
Background The methylotrophic budding yeast Pichia pastoris GS115 is a powerful expression system and hundreds of heterologous proteins have been successfully expressed in this strain. Recently, P.
Qiquan Zhang, Xiaolu Wang, Huiying Luo, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Xiaoyun Su, Huoqing Huang, Bin Yao, Yingguo Bai, Jie Zhang   +11 more
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Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?

Molecules, 2020
The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Caitlin Cridland, Glenda Gillaspy
doaj   +1 more source